Necrotizing granulomatous vasculitis of the gallbladder. A case report: Necrotizing granulomatous vasculitis of the gallbladder

Mahir Tayfur

doi:10.28982/josam.8226

Authors

Mahir Tayfur Department of Pathology, Erzincan Binali Yıldırım University, Faculty of Medicine, Mengücek Gazi Training and Research Hospital, Erzincan, Turkey https://orcid.org/0000-0001-7137-5465

DOI:

https://doi.org/10.28982/josam.8226

Keywords:

gallbladder, vasculitis, granuloma, necrotizing granulomatous vasculitis

Abstract

Granulomatous inflammation is a tissue reaction caused by various factors. Granulomatous vasculitis is a subgroup of systemic necrotizing vasculitis. Necrotizing granulomatous vasculitis is a rare inflammatory condition consisting of granulomas restricted to blood vessels. Although it is quite rare in the gallbladder, numerous necrotizing granulomas were found in the gallbladder in this particular case. Many acute and chronic inflammatory cells, including eosinophils, were seen within the fibrinoid necrosis in the vascular structures in the central area of these granulomas.

Downloads

Download data is not yet available.

References

Lam R, Zakko A, Petrov JC, Kumar P, Duffy AJ, Muniraj T. Gallbladder Disorders: A Comprehensive Review. Dis Mon. 2021 Jul;67(7):101130. doi: 10.1016/j.disamonth.2021.101130. DOI: https://doi.org/10.1016/j.disamonth.2021.101130

Iyer SG, Ravishankar KD, Huang E, Masud K. Acute acalculous cholecystitis: challenging the myths. HPB (Oxford). 2007;9(2):131-4. doi: 10.1080/13651820701315307. DOI: https://doi.org/10.1080/13651820701315307

Mossaab G, Khlifa MB, Karim N, Moez B, Oussama J, Hajer N, et al. Acute acalculous cholecystitis in hospitalized patients in intensive care unit: study of 5 cases. Heliyon. 2022 Nov 11;8(11):e11524. doi: 10.1016/j.heliyon.2022.e11524. eCollection 2022 Nov. DOI: https://doi.org/10.1016/j.heliyon.2022.e11524

Schirmer BD, Winters KL, Edlich RF. Cholelithiasis and cholecystitis. J Long Term Eff Med Implants. 2005;15(3):329-38. doi: 10.1615/jlongtermeffmedimplants.v15.i3.90. DOI: https://doi.org/10.1615/JLongTermEffMedImplants.v15.i3.90

Randi R, Franceschi S, La Vecchia C. Gallbladder cancer worldwide: geographical distribution and risk factors. Int J Cancer. 2006 Apr 1;118(7):1591-602. doi: 10.1002/ijc.21683. DOI: https://doi.org/10.1002/ijc.21683

Lin WR, Lin DY, Tai DI, Hsieh SY, Lin CY, Sheen IS, et al. Prevalence of and risk factors for gallbladder polyps detected by ultrasonography among healthy Chinese: analysis of 34 669 cases. J Gastroenterol Hepatol. 2008 Jun;23(6):965-9. doi: 10.1111/j.1440-1746.2007.05071.x. DOI: https://doi.org/10.1111/j.1440-1746.2007.05071.x

Shah KK, Pritt BS, Alexander MP. Histopathologic review of granulomatous inflammation. J Clin Tuberc Other Mycobact Dis. 2017 Feb 10;7:1-12. doi: 10.1016/j.jctube.2017.02.001. DOI: https://doi.org/10.1016/j.jctube.2017.02.001

Marquez J, Flores D, Candia L, Espinoza LR. Granulomatous vasculitis. Curr Rheumatol Rep 2003 Apr;5:128-35. doi:10.1007/s11926-003-0040-6. DOI: https://doi.org/10.1007/s11926-003-0040-6

Hernandez-Rodriguez J, Tan CD, Rodriguez ER, Hoffman, GS. Single-organ Gallbladder Vasculitis. Characterization and Distinction From Systemic Vasculitis Involving the Gallbladder. An Analysis of 61 Patients. Medicine (Baltimore). 2014 Nov;93(24):405-13. doi: 10.1097/MD.0000000000000205. DOI: https://doi.org/10.1097/MD.0000000000000205

Hernandez-Rodriguez J, Hoffman GS. Abdominal structures are frequently involved in systemic vasculitides. Updating single-organ vasculitis. Curr Opin Rheumatol. 2012;24:38-45. DOI: https://doi.org/10.1097/BOR.0b013e32834d8482

Chen KT. Gallbladder vasculitis. J Clin Gastroenterol. 1989;11:537-40. DOI: https://doi.org/10.1097/00004836-198910000-00009

Sujobert P, Fardet L, Marie I, Duhaut P, Cohen P, Grange C, et al. Mesenteric ischemia in giant cell arteritis: 6 cases and a systematic review. J Rheumatol. 2007 Aug;34(8):1727-32. Epub 2007 Jul 1. PMID: 17611981.

Terrier B, Carrat F, Krastinova E, Marie I, Launay D, Lacraz A, et al. Prognostic factors of survival in patients with non-infectious mixed cryoglobulinaemia vasculitis: data from 242 cases included in the CryoVas survey. Ann Rheum Dis. 2013;72:374-80. DOI: https://doi.org/10.1136/annrheumdis-2012-201405

Pagnoux C, Mahr A, Cohen P, Guillevin L. Presentation and outcome of gastrointestinal involvement in systemic necrotizing vasculitides: analysis of 62 patients with polyarteritis nodosa, microscopic polyangiitis, Wegener granulomatosis, Churg-Strauss syndrome, or rheumatoid arthritis-associated vasculitis. Medicine (Baltimore). 2005;84:115-28. DOI: https://doi.org/10.1097/01.md.0000158825.87055.0b