Yıl 2021, Cilt 5 , Sayı 2, Sayfalar 120 - 123 2021-02-01

Background/Aim: Diabetic macular edema (DME) is the main cause of visual loss in diabetic patients. Although it is known that diabetes mellitus could affect all corneal layers, there is no data about the morphological and quantitative changes of corneal endothelium in patients with DME. The aim of this study is to evaluate the corneal endothelial cell density (CD), morphology and central corneal thickness (CCT) in patients with DME. Methods: This retrospective study included 47 diabetic patients (79 eyes) with DME, 48 diabetic patients (93 eyes) without DME, and 46 nondiabetic subjects (74 eyes). Diagnosis of DME was based on fundoscopy and optical coherence tomography imaging. The corneal endothelial structure and CCT were evaluated using non-contact specular microscopy. The endothelial CD (cells/mm2), coefficient variation of cell area (CV), percentage of hexagonality (HEX) and CCT of the three subgroups were compared. Results: The mean age of participants was 59.8 (8.3) years. There was no significant difference in terms of age between diabetic patients and control subjects (P=0.761). In the diabetic subgroups, HbA1c levels and the number of patients receiving insulin were similar (P=0.962, P=0.082, respectively), but the mean duration of diabetes was significantly longer in the DME subgroup than in the no-DME subgroup (P=0.015). Patients in the DME subgroup did not differ from the patients in the no-DME and control subgroups with regards to endothelial CD and CCT. However, there was a statistically significant decrease in HEX and increase in CV in patients with DME (P=0.012, P=0.012, respectively). Conclusion: Patients with DME were found to have higher rates of polymegathism and polymorphism although there were no significant changes in corneal endothelial CD and CCT. These alterations may be the first signs of early corneal damage in patients with DME.
corneal endothelium, diabetic macular edema, polymegathism, polymorphism, specular microscopy
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Birincil Dil en
Konular Göz Hastalıkları
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0002-1686-5458
Yazar: Gamze UÇAN GÜNDÜZ (Sorumlu Yazar)
Kurum: ULUDAG UNIVERSITY, FACULTY OF MEDICINE
Ülke: Turkey


Orcid: 0000-0002-7961-3664
Yazar: Hafize Gökben ULUTAŞ
Kurum: BURSA YÜKSEK İHTİSAS EĞİTİM VE ARAŞTIRMA HASTANESİ
Ülke: Turkey


Orcid: 0000-0002-4253-7856
Yazar: Neslihan YENER
Kurum: BURSA YÜKSEK İHTİSAS EĞİTİM VE ARAŞTIRMA HASTANESİ
Ülke: Turkey


Orcid: 0000-0002-1219-8304
Yazar: Özgür YALÇINBAYIR
Kurum: ULUDAG UNIVERSITY, FACULTY OF MEDICINE
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Şubat 2021

Bibtex @araştırma makalesi { josam862849, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2021}, volume = {5}, pages = {120 - 123}, doi = {10.28982/josam.862849}, title = {Corneal endothelial alterations in patients with diabetic macular edema}, key = {cite}, author = {Uçan Gündüz, Gamze and Ulutaş, Hafize Gökben and Yener, Neslihan and Yalçınbayır, Özgür} }
APA Uçan Gündüz, G , Ulutaş, H , Yener, N , Yalçınbayır, Ö . (2021). Corneal endothelial alterations in patients with diabetic macular edema . Journal of Surgery and Medicine , 5 (2) , 120-123 . DOI: 10.28982/josam.862849
MLA Uçan Gündüz, G , Ulutaş, H , Yener, N , Yalçınbayır, Ö . "Corneal endothelial alterations in patients with diabetic macular edema" . Journal of Surgery and Medicine 5 (2021 ): 120-123 <http://jsurgmed.com/tr/pub/issue/60239/862849>
Chicago Uçan Gündüz, G , Ulutaş, H , Yener, N , Yalçınbayır, Ö . "Corneal endothelial alterations in patients with diabetic macular edema". Journal of Surgery and Medicine 5 (2021 ): 120-123
RIS TY - JOUR T1 - Corneal endothelial alterations in patients with diabetic macular edema AU - Gamze Uçan Gündüz , Hafize Gökben Ulutaş , Neslihan Yener , Özgür Yalçınbayır Y1 - 2021 PY - 2021 N1 - doi: 10.28982/josam.862849 DO - 10.28982/josam.862849 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 120 EP - 123 VL - 5 IS - 2 SN - -2602-2079 M3 - doi: 10.28982/josam.862849 UR - https://doi.org/10.28982/josam.862849 Y2 - 2021 ER -
EndNote %0 Journal of Surgery and Medicine Corneal endothelial alterations in patients with diabetic macular edema %A Gamze Uçan Gündüz , Hafize Gökben Ulutaş , Neslihan Yener , Özgür Yalçınbayır %T Corneal endothelial alterations in patients with diabetic macular edema %D 2021 %J Journal of Surgery and Medicine %P -2602-2079 %V 5 %N 2 %R doi: 10.28982/josam.862849 %U 10.28982/josam.862849
ISNAD Uçan Gündüz, Gamze , Ulutaş, Hafize Gökben , Yener, Neslihan , Yalçınbayır, Özgür . "Corneal endothelial alterations in patients with diabetic macular edema". Journal of Surgery and Medicine 5 / 2 (Şubat 2021): 120-123 . https://doi.org/10.28982/josam.862849
AMA Uçan Gündüz G , Ulutaş H , Yener N , Yalçınbayır Ö . Corneal endothelial alterations in patients with diabetic macular edema. J Surg Med. 2021; 5(2): 120-123.
Vancouver Uçan Gündüz G , Ulutaş H , Yener N , Yalçınbayır Ö . Corneal endothelial alterations in patients with diabetic macular edema. Journal of Surgery and Medicine. 2021; 5(2): 120-123.
IEEE G. Uçan Gündüz , H. Ulutaş , N. Yener ve Ö. Yalçınbayır , "Corneal endothelial alterations in patients with diabetic macular edema", Journal of Surgery and Medicine, c. 5, sayı. 2, ss. 120-123, Şub. 2021, doi:10.28982/josam.862849