Yıl 2021, Cilt 5 , Sayı 2, Sayfalar 140 - 143 2021-02-01

Assessment of serum TWEAK levels in patients with familial Mediterranean fever

Gökhan YAVUZBİLGE [1] , Muhammed OKUYUCU [2] , Yeşim CİVİL [3] , Serkan GÜNAYDIN [4] , Bahattin AVCI [5]


Background/Aim: Mediterranean fever is an autoinflammatory disease characterized by recurrent attacks. Tumor necrosis factor (TNF) - like weak inducer of apoptosis (TWEAK) is a member of the TNF ligand family, and it has been reported to contribute significantly to the initiation of many inflammatory and immunological processes. In previous studies, an increasing amount of evidence has implicated the participation of TWEAK / Fn14 pathway in the pathogenesis of rheumatic inflammatory diseases that include rheumatoid arthritis, systemic lupus erythematosus and Behçet's disease. The aim of this study was to investigate the serum TWEAK levels of patients with Familial Mediterranean fever (FMF) and its possible relationship with inflammatory markers and disease activity. Methods: Our study included 20 patients with FMF and 19 healthy volunteers. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) were measured, and PRAS disease severity score was determined in patients with FMF. Also, the FMF attack period was questioned. Serum TWEAK levels were measured with available commercial Enzyme Linked Immunosorbent Assay kits. Results: There was no significant difference in terms of age and gender between the FMF group and the healthy control group (P>0.05, for all). ESR, CRP and serum TWEAK levels were significantly higher in patients with FMF (P<0.001 for all). PRAS score in FMF patients was 3.4. Serum TWEAK level was not correlated with ESR (r=-0.042, P=0.0801), CRP (r=-0.017 P=0.921), or PRAS score (r=0.247, P=0.149). The ESR and CRP levels of patients in FMF attack period were significantly higher compared to attack free period (P<0.001 for both) whereas there was no significant difference in serum TWEAK levels (P=0.686). Conclusions: Serum TWEAK levels are increased in FMF disease with attacks. However, this increase is not associated with increased ESR and CRP during FMF attacks. These results indicate that the TWEAK / Fn14 pathway plays a role in earlier stages where the inflammatory pathways have not differentiated yet. Serum TWEAK levels appear to be more successful in reflecting a lower degree of inflammation compared to ESR and CRP.
Familial Mediterranean Fever, TWEAK, inflammation, Biomarker
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Birincil Dil en
Konular Romatoloji
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0002-8879-8859
Yazar: Gökhan YAVUZBİLGE (Sorumlu Yazar)
Kurum: ONDOKUZ MAYIS UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-6026-2024
Yazar: Muhammed OKUYUCU
Kurum: ONDOKUZ MAYIS UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-9662-244X
Yazar: Yeşim CİVİL
Kurum: ONDOKUZ MAYIS UNIVERSITY
Ülke: Turkey


Orcid: 0000-0002-1131-2531
Yazar: Serkan GÜNAYDIN
Kurum: ONDOKUZ MAYIS UNIVERSITY
Ülke: Turkey


Orcid: 0000-0001-6471-6495
Yazar: Bahattin AVCI
Kurum: ONDOKUZ MAYIS UNIVERSITY
Ülke: Turkey


Destekleyen Kurum yok
Proje Numarası yok
Tarihler

Yayımlanma Tarihi : 1 Şubat 2021

Bibtex @araştırma makalesi { josam833593, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2021}, volume = {5}, pages = {140 - 143}, doi = {10.28982/josam.833593}, title = {Assessment of serum TWEAK levels in patients with familial Mediterranean fever}, key = {cite}, author = {Yavuzbilge, Gökhan and Okuyucu, Muhammed and Civil, Yeşim and Günaydın, Serkan and Avcı, Bahattin} }
APA Yavuzbilge, G , Okuyucu, M , Civil, Y , Günaydın, S , Avcı, B . (2021). Assessment of serum TWEAK levels in patients with familial Mediterranean fever . Journal of Surgery and Medicine , 5 (2) , 140-143 . DOI: 10.28982/josam.833593
MLA Yavuzbilge, G , Okuyucu, M , Civil, Y , Günaydın, S , Avcı, B . "Assessment of serum TWEAK levels in patients with familial Mediterranean fever" . Journal of Surgery and Medicine 5 (2021 ): 140-143 <http://jsurgmed.com/tr/pub/issue/60239/833593>
Chicago Yavuzbilge, G , Okuyucu, M , Civil, Y , Günaydın, S , Avcı, B . "Assessment of serum TWEAK levels in patients with familial Mediterranean fever". Journal of Surgery and Medicine 5 (2021 ): 140-143
RIS TY - JOUR T1 - Assessment of serum TWEAK levels in patients with familial Mediterranean fever AU - Gökhan Yavuzbilge , Muhammed Okuyucu , Yeşim Civil , Serkan Günaydın , Bahattin Avcı Y1 - 2021 PY - 2021 N1 - doi: 10.28982/josam.833593 DO - 10.28982/josam.833593 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 140 EP - 143 VL - 5 IS - 2 SN - -2602-2079 M3 - doi: 10.28982/josam.833593 UR - https://doi.org/10.28982/josam.833593 Y2 - 2021 ER -
EndNote %0 Journal of Surgery and Medicine Assessment of serum TWEAK levels in patients with familial Mediterranean fever %A Gökhan Yavuzbilge , Muhammed Okuyucu , Yeşim Civil , Serkan Günaydın , Bahattin Avcı %T Assessment of serum TWEAK levels in patients with familial Mediterranean fever %D 2021 %J Journal of Surgery and Medicine %P -2602-2079 %V 5 %N 2 %R doi: 10.28982/josam.833593 %U 10.28982/josam.833593
ISNAD Yavuzbilge, Gökhan , Okuyucu, Muhammed , Civil, Yeşim , Günaydın, Serkan , Avcı, Bahattin . "Assessment of serum TWEAK levels in patients with familial Mediterranean fever". Journal of Surgery and Medicine 5 / 2 (Şubat 2021): 140-143 . https://doi.org/10.28982/josam.833593
AMA Yavuzbilge G , Okuyucu M , Civil Y , Günaydın S , Avcı B . Assessment of serum TWEAK levels in patients with familial Mediterranean fever. J Surg Med. 2021; 5(2): 140-143.
Vancouver Yavuzbilge G , Okuyucu M , Civil Y , Günaydın S , Avcı B . Assessment of serum TWEAK levels in patients with familial Mediterranean fever. Journal of Surgery and Medicine. 2021; 5(2): 140-143.
IEEE G. Yavuzbilge , M. Okuyucu , Y. Civil , S. Günaydın ve B. Avcı , "Assessment of serum TWEAK levels in patients with familial Mediterranean fever", Journal of Surgery and Medicine, c. 5, sayı. 2, ss. 140-143, Şub. 2021, doi:10.28982/josam.833593