Yıl 2021, Cilt 5 , Sayı 2, Sayfalar 144 - 148 2021-02-01

Background/Aim: Tacrolimus is a commonly used agent for immunosuppression in organ transplantation with known nephrotoxic effects. We think that kidney-sparing therapy should be added to current treatment protocols. We aimed to observe the protective effect of resveratrol (RSV) against the adverse effects of tacrolimus (TAC) on rat kidneys. Methods: Twenty-four rats were randomly divided into the following three groups of eight rats each: Control, TAC, and RSV. The control group was not treated in any way. Tacrolimus was administered to the TAC group. In addition to tacrolimus use, resveratrol was administered to the RSV group. At the end of the experiment, one kidney was used for histopathological examination and the other, for biochemical examination. Results were analyzed statistically. Results: IL-1β, IL-6, TNF-Alpha levels in the control group were significantly lower than those in TAC and RSV groups (IL-1; P<0.001, P<0.001, IL-6; P<0.001 P=0.002, TNF-Alpha; P<0.001, P<0.001), and those in the RSV group were significantly lower than those in the TAC group (IL-1: P=0.032, IL-6: P=0.001 TNF-Alpha: P=0.026). TAS levels of the control group were significantly higher than those of the TAC group (P=0.030). TOS and OSI levels of the control group were significantly lower than those of the TAC and RSV groups (TOS: P=0.002, P=0.012, OSI: P=0.001, P=0.004). In histopathological evaluation, the TAC group showed the highest levels of fibrosis. The differences between the control and TAC groups and the TAC and RSV groups were statistically significant (P=0.003, P=0.003). Conclusion: Resveratrol has a protective effect against the adverse effects of tacrolimus on the kidney, which may be because of its anti-inflammatory and antioxidant properties.
Anti-inflammatory, antioxidant, immunosuppression, resveratrol, tacrolimus
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Birincil Dil en
Konular Cerrahi
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0002-2786-3805
Yazar: Hüseyin ÖZDEN (Sorumlu Yazar)
Kurum: AHİ EVRAN ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0002-9127-3201
Yazar: Muhammed GÖMEÇ
Kurum: CUMHURİYET ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0001-5936-4210
Yazar: Yaşar ŞAHİN
Kurum: KIRIKKALE ÜNİVERSİTESİ, VETERİNER FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0002-5107-5999
Yazar: Gökhan KARACA
Kurum: KIRIKKALE YÜKSEK İHTİSAS HASTANESİ
Ülke: Turkey


Orcid: 0000-0003-2706-9625
Yazar: Huri BULUT
Kurum: BEZM-İ ÂLEM VAKIF ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Orcid: 0000-0002-5489-2222
Yazar: Asuman KİLİTCİ
Kurum: ahi evran üniversitesi tıp fakültesi patoloji
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Şubat 2021

Bibtex @araştırma makalesi { josam831592, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2021}, volume = {5}, pages = {144 - 148}, doi = {10.28982/josam.831592}, title = {Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus}, key = {cite}, author = {Özden, Hüseyin and Gömeç, Muhammed and Şahin, Yaşar and Karaca, Gökhan and Bulut, Huri and Kilitci, Asuman} }
APA Özden, H , Gömeç, M , Şahin, Y , Karaca, G , Bulut, H , Kilitci, A . (2021). Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus . Journal of Surgery and Medicine , 5 (2) , 144-148 . DOI: 10.28982/josam.831592
MLA Özden, H , Gömeç, M , Şahin, Y , Karaca, G , Bulut, H , Kilitci, A . "Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus" . Journal of Surgery and Medicine 5 (2021 ): 144-148 <http://jsurgmed.com/tr/pub/issue/60239/831592>
Chicago Özden, H , Gömeç, M , Şahin, Y , Karaca, G , Bulut, H , Kilitci, A . "Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus". Journal of Surgery and Medicine 5 (2021 ): 144-148
RIS TY - JOUR T1 - Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus AU - Hüseyin Özden , Muhammed Gömeç , Yaşar Şahin , Gökhan Karaca , Huri Bulut , Asuman Kilitci Y1 - 2021 PY - 2021 N1 - doi: 10.28982/josam.831592 DO - 10.28982/josam.831592 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 144 EP - 148 VL - 5 IS - 2 SN - -2602-2079 M3 - doi: 10.28982/josam.831592 UR - https://doi.org/10.28982/josam.831592 Y2 - 2021 ER -
EndNote %0 Journal of Surgery and Medicine Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus %A Hüseyin Özden , Muhammed Gömeç , Yaşar Şahin , Gökhan Karaca , Huri Bulut , Asuman Kilitci %T Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus %D 2021 %J Journal of Surgery and Medicine %P -2602-2079 %V 5 %N 2 %R doi: 10.28982/josam.831592 %U 10.28982/josam.831592
ISNAD Özden, Hüseyin , Gömeç, Muhammed , Şahin, Yaşar , Karaca, Gökhan , Bulut, Huri , Kilitci, Asuman . "Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus". Journal of Surgery and Medicine 5 / 2 (Şubat 2021): 144-148 . https://doi.org/10.28982/josam.831592
AMA Özden H , Gömeç M , Şahin Y , Karaca G , Bulut H , Kilitci A . Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus. J Surg Med. 2021; 5(2): 144-148.
Vancouver Özden H , Gömeç M , Şahin Y , Karaca G , Bulut H , Kilitci A . Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus. Journal of Surgery and Medicine. 2021; 5(2): 144-148.
IEEE H. Özden , M. Gömeç , Y. Şahin , G. Karaca , H. Bulut ve A. Kilitci , "Protective effect of resveratrol on the kidney in rats under immunosuppression with tacrolimus", Journal of Surgery and Medicine, c. 5, sayı. 2, ss. 144-148, Şub. 2021, doi:10.28982/josam.831592