Year 2020, Volume 4 , Issue 9, Pages 779 - 783 2020-09-01

Sexual dysfunction and associated risk factors in multiple sclerosis
Multipl sklerozda seksüel disfonksiyon ve ilişkili risk fakörleri

Mesrure KÖSEOĞLU [1] , Rabia Gökçen GÖZÜBATIK ÇELİK [2] , Mesude TUTUNCU [3] , Ayhan BİNGÖL [4] , Bahar ERBAS [5] , Duygu DERİNGÖL [6] , Dilek ATAKLI [7]


Aim: Sexual dysfunction (SD) is quite common in multiple sclerosis (MS), and exhibits a multifactorial pattern. This study was set out to evaluate the frequency of SD and explore the related factors to support the quality of MS patients’ lives. Methods: This cross-sectional study included 96 volunteer RRMS patients between 18 and 60 years of age who were diagnosed with MS according to the Mc Donald criteria between 2018 and 2019 in our hospital. Multiple sclerosis intimacy and sexuality questionnaire-19 (MSISQ-19), Arizona Sexual Experience Scale (ASEX), Multiple Sclerosis Inventory of Cognition (MUSIC) and Beck Depression Inventory (BDI) questionnaires were used. Results: Mean age of the patients was 38.46 (8.47) (min-max:20 – 60 years) years, and mean disease period was 77.02 (70.62) (3–324 months) months. Mean Extended Disability Status Scale (EDSS) score was 2.1 (1.33) (0-5) with a standard deviation of 80.5%. A negative correlation was observed between MUSIC cognitive and EDSS (P=0.017; r=-0.273), and BDI scores (P=0.003; r=-0.306). A significant and positive correlation was detected between MSISQ score (P<0.001; r=0.476) and BDI (P<0.001; r=0.529) in MUSIC fatigue test results. A negative and poor correlation was found between MUSIC fatigue and MUSIC cognitive score (P<0.001; r=-0.365). In patients with depression, mean MUSIC cognitive scores were lower (P=0.009), while MUSIC fatigue scores were higher (P<0.001). Age, educational status, presence of secondary SD were independent risk factors. Conclusion: SD, a quite common condition in MS, may be decreased to increase the quality of lives of patients through treatment of psychosocial factors associated with cognitive state.
Amaç: Cinsel işlev bozukluğu (CİB), multipl sklerozda (MS) sık görülen multifaktöryel bir durumdur. Bu çalışma, MS’de CİB sıklığını değerlendirmek ve ilgili faktörleri araştırmak amacıyla düzenlenmiştir. Yöntemler: Kesitsel özellikteki bu çalışmaya, 2018-2019 yıllarında,18 ile 60 yaşları arasında Mc Donald kriterlerine göre kesin relapsing remitting multipl skleroz (RRMS) tanısı alan 96 hasta gönüllü olarak çalışmaya dahil edildi. Multiple sclerosis intimacy and sexuality questionnaire-19 (MSISQ-19), Arizona Sexual Experience Scale (ASEX), Multiple Sclerosis Inventory of Cognition (MUSIC) ve Beck Depresyon Ölçeği (BDI) anketleri uygulandı. Bulgular: Hastaların yaş ortalaması 38,46 (8,47) (min-maks: 20 - 60 yıl) yıldı; ortalama hastalık süresi 77,02 (70,62) (3 - 324 ay) aydı. Ortalama Genişletilmiş Özürlülük Durumu Ölçeği (EDSS) puanı 2,1 (1,33) (0-5) ve standart sapma %80,5 idi. MÜZİK bilişsel puanı ile EDSS puanı (P=0,017; r=-0,273) ve MÜZİK bilişsel ve BDÖ puanı arasında (P=0,003; r=-0,306) negatif bir korelasyon görüldü. Müzik yorgunluk testi sonuçlarında MSISQ skoru (P<0,001; r=0,476) ile BDÖ (P<0,001; r=0,529) arasında anlamlı ve pozitif bir ilişki tespit edildi. Müzik yorgunluğu ile müzik bilişsel puanı arasında negatif ve zayıf ilişki bulundu (P<0,001; r=-0,365). Ortalama MUZİK bilişsel puanı depresyonu olanlarda daha düşüktü (P=0,009); MÜZİK yorgunluk puanları depresyon grubunda daha yüksek saptandı (P<0,001). Yaş, eğitim durumu, ikincil seksüel disfonksiyon (SD) varlığı bağımsız risk faktörleriydi. Sonuç: SD, MS'te çok yaygındır. Kognitif durumla da ilişkili olan psikososyal faktörlerin tedavisi ile SD oranı azaltılarak hastaların yaşam kalitesi arttırılabilir.
  • 1. Chalah MA, Ayache SS. Cognitive behavioral therapies and multiple sclerosis fatigue: A review of literature. Journal of Clinical Neuroscience. 2018;52:1-4.
  • 2. Çelik DB, Poyraz EÇ, Bingöl A, İdiman E, Özakbaş S, Kaya D. Sexual dysfunction in multiple sclerosis: Gender differences. Journal of the Neurological Sciences. 2013;324:17-20.
  • 3. Dupont S. Multiple sclerosis and sexual functioning -a review. Clin Rehabil. 1995;9:135-41.
  • 4. Dunya CP, Tulek Z, Uchiyama T, Haslam C, Panicker JN. Systematic review of the prevalence, symptomatology and management options of sexual dysfunction in women with multiple sclerosis. Neurourology and Urodynamics. 2019;39:83-95.
  • 5. Demirkiran M, Sarica Y, Uguz S, Yerdelen D, Aslan K. Multiple sclerosis patients with and without sexual dysfunction: are there any differences? Mult Scler. 2006;12:209-14.
  • 6. Zorzon M, Zivadinov R, Bosco A, Hocking JS, De Livera AM, Taylor KL, et al. Sexual dysfunction in multiple sclerosis: a case–control study. I. Frequency and comparison of groups. Mult Scler. 1999;5:418-27.
  • 7. Zivadinov R, Zorzon M, Bosco A, Bragadin LM, Moretti R, Bonfigli L, et al. Sexual Disfunction and Associated Risk Factors in Multiple Sclerosis II. Correlation analysis. Mult Scler. 1999;5:428-31.
  • 8. Drulovic J, Kisic Tepavcevic D, Pekmezovic T. Epidemiology, diagnosis and management of sexual dysfunction in multiple sclerosis. Acta Neurologica Belgica. 2020;120:791-7.
  • 9. Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded dis- ability status scale (EDSS). Neurology. 1983;33:1444-52.
  • 10. Tudor KI, Panicker JN. Management of erectile dysfunction in neurological patients. In: Minhas S, Mulhall J, editors. Male Sexual Dysfunction: A Clinical Guide: John Wiley & Sons, Ltd;2017.
  • 11. McGahuey CA, Gelenberg AJ, Francisco AL, Delgado PL, McKnight KM, Manber R. The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther. 2000;26:25-40.
  • 12. Calabrese P, Kalbe E, Kessler J. Ein neuropsychologisches Screening zur Erfassung kognitiver Störungen bei MS-Patienten: das Sklerose Inventarium Cognition (MUSIC). Neuropsychologia: An International Journal in Behavioural and Cognitive Neuroscience. 2004;30:384-8.
  • 13. Hulter BM, Lundberg PO. Sexual function in women with advanced multiple sclerosis. J Neurol Neurosurg Psychiatry. 1995;59:83-6.
  • 14. Calabro RS, Russo M, Dattola V, Luca RD, Leo A, Grisolaghi J, et al. Sexual Function in Young Individuals with Multiple Sclerosis: Does Disability Matter? J Neurosci Nurs. 2018;50:161-6.
  • 15. Tepavcevic DK, Kostic J, Basuroski ID, Stojsavljevic N, Pekmezovic T, Drulovic J. The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis. Mult Scler. 2008;14:1131-6.
  • 16. Kisic-Tepavcevic D, Pekmezovic T, Trajkovic G, Stojsavljevic N, Dujmovic I, Mesaros S, et al. Sexual dysfunction in multiple sclerosis: a 6-year follow-up study. J Neurol Sci. 2015;358:317–23.
  • 17. Ashtari F, Rezvani R, Afshar H. Sexual dysfunction in women with multiple sclerosis: dimensions and contributory factors. J Res Med Sci. 2014;19:228-33.
  • 18. Hösl KM, Deutsch M, Wang R, Roy S, Winder K, Niklewski G, et al. Sexual dysfunction seems to trigger depression in female multiple sclerosis patients. Eur Neurol. 2018;80:34‐41.
  • 19. Solmaz V, Ozlece HK, Him A, Güneş A, Cordano C, Aksoy D, et al. Evaluation of the association between sexual dysfunction and demyelinating plaque location and number in female multiple sclerosis patients. Neurol Res. 2018;40:683-8.
  • 20. Gava G, Visconti M, Salvi F, Bartolomei I, Seracchioli R, Meriggiola MC. Prevalence and psychopathological determinants of sexual dysfunction and related distress in women with and without multiple sclerosis. J Sex Med. 2019;16:833-42.
Primary Language en
Subjects Medicine
Journal Section Research article
Authors

Orcid: 0000-0003-0469-0064
Author: Mesrure KÖSEOĞLU
Institution: Sağlık Bilimleri Üniversitesi, Bakırköy Prof Dr. Mazhar Osman Ruh Sağlığı ve Sinir hastalıkları Eğitim ve Araştırma Hastanesi Nöroloji Bölümü, İstanbul,Turkiye
Country: Turkey


Orcid: 0000-0002-8186-8703
Author: Rabia Gökçen GÖZÜBATIK ÇELİK (Primary Author)
Institution: Sağlık Bilimleri Üniversitesi, Bakırköy Prof Dr. Mazhar Osman Ruh Sağlığı ve Sinir hastalıkları Eğitim ve Araştırma Hastanesi Nöroloji Bölümü, İstanbul,Turkiye
Country: Turkey


Orcid: 0000-0002-1176-3156
Author: Mesude TUTUNCU
Institution: Sağlık Bilimleri Üniversitesi, Bakırköy Prof Dr. Mazhar Osman Ruh Sağlığı ve Sinir hastalıkları Eğitim ve Araştırma Hastanesi Nöroloji Bölümü, İstanbul,Turkiye
Country: Turkey


Orcid: 0000-0002-6024-6550
Author: Ayhan BİNGÖL
Institution: Behavioral Change Academy, Istanbul, Turkey
Country: Turkey


Orcid: 0000-0002-6125-7761
Author: Bahar ERBAS
Institution: 3Deparment of Pharmacology, Demiroglu Bilim University Medical Faculty and Neurology Clinic, İstanbul Florence Nightingale Hospital
Country: Turkey


Orcid: 0000-0002-0921-3905
Author: Duygu DERİNGÖL
Institution: Sağlık Bilimleri Üniversitesi, Bakırköy Prof Dr Mazhar Osman Ruh Sağlığı ve Sinir Hastalıkları Eğitim Ve Araştırma Hastanesi Nöroloji Bölümü, İstanbul, Turkiye
Country: Turkey


Orcid: 0000-0001-6458-8374
Author: Dilek ATAKLI
Institution: Sağlık Bilimleri Üniversitesi, Bakırköy Prof Dr. Mazhar Osman Ruh Sağlığı ve Sinir hastalıkları Eğitim ve Araştırma Hastanesi Nöroloji Bölümü, İstanbul,Turkiye
Country: Turkey


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Dates

Publication Date : September 1, 2020

Bibtex @research article { josam800830, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {779 - 783}, doi = {10.28982/josam.800830}, title = {Sexual dysfunction and associated risk factors in multiple sclerosis}, key = {cite}, author = {Köseoğlu, Mesrure and Gözübatık Çeli̇k, Rabia Gökçen and Tutuncu, Mesude and Bi̇ngöl, Ayhan and Erbas, Bahar and Deri̇ngöl, Duygu and Ataklı, Dilek} }
APA Köseoğlu, M , Gözübatık Çeli̇k, R , Tutuncu, M , Bi̇ngöl, A , Erbas, B , Deri̇ngöl, D , Ataklı, D . (2020). Sexual dysfunction and associated risk factors in multiple sclerosis . Journal of Surgery and Medicine , 4 (9) , 779-783 . DOI: 10.28982/josam.800830
MLA Köseoğlu, M , Gözübatık Çeli̇k, R , Tutuncu, M , Bi̇ngöl, A , Erbas, B , Deri̇ngöl, D , Ataklı, D . "Sexual dysfunction and associated risk factors in multiple sclerosis" . Journal of Surgery and Medicine 4 (2020 ): 779-783 <http://jsurgmed.com/en/pub/issue/56766/800830>
Chicago Köseoğlu, M , Gözübatık Çeli̇k, R , Tutuncu, M , Bi̇ngöl, A , Erbas, B , Deri̇ngöl, D , Ataklı, D . "Sexual dysfunction and associated risk factors in multiple sclerosis". Journal of Surgery and Medicine 4 (2020 ): 779-783
RIS TY - JOUR T1 - Sexual dysfunction and associated risk factors in multiple sclerosis AU - Mesrure Köseoğlu , Rabia Gökçen Gözübatık Çeli̇k , Mesude Tutuncu , Ayhan Bi̇ngöl , Bahar Erbas , Duygu Deri̇ngöl , Dilek Ataklı Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.800830 DO - 10.28982/josam.800830 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 779 EP - 783 VL - 4 IS - 9 SN - -2602-2079 M3 - doi: 10.28982/josam.800830 UR - https://doi.org/10.28982/josam.800830 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Sexual dysfunction and associated risk factors in multiple sclerosis %A Mesrure Köseoğlu , Rabia Gökçen Gözübatık Çeli̇k , Mesude Tutuncu , Ayhan Bi̇ngöl , Bahar Erbas , Duygu Deri̇ngöl , Dilek Ataklı %T Sexual dysfunction and associated risk factors in multiple sclerosis %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 9 %R doi: 10.28982/josam.800830 %U 10.28982/josam.800830
ISNAD Köseoğlu, Mesrure , Gözübatık Çeli̇k, Rabia Gökçen , Tutuncu, Mesude , Bi̇ngöl, Ayhan , Erbas, Bahar , Deri̇ngöl, Duygu , Ataklı, Dilek . "Sexual dysfunction and associated risk factors in multiple sclerosis". Journal of Surgery and Medicine 4 / 9 (September 2020): 779-783 . https://doi.org/10.28982/josam.800830
AMA Köseoğlu M , Gözübatık Çeli̇k R , Tutuncu M , Bi̇ngöl A , Erbas B , Deri̇ngöl D , Ataklı D . Sexual dysfunction and associated risk factors in multiple sclerosis. J Surg Med. 2020; 4(9): 779-783.
Vancouver Köseoğlu M , Gözübatık Çeli̇k R , Tutuncu M , Bi̇ngöl A , Erbas B , Deri̇ngöl D , Ataklı D . Sexual dysfunction and associated risk factors in multiple sclerosis. Journal of Surgery and Medicine. 2020; 4(9): 779-783.