Year 2020, Volume 4 , Issue 9, Pages 716 - 719 2020-09-01

Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation
Arteriovenöz fistül oluşturulmasında yeni endotelyal hasar inhibitörü kullanılmasının etki ve güvenirliği

Emced KHALİL [1] , Çağrı AKALIN [2]


Aim: Patients with end-stage renal disease need accurate and effective vascular access for hemodialysis. Although renal transplantation is the golden standard treatment that provides a life without hemodialysis, an arteriovenous (AV) fistula is the most frequent method for sustaining long-term hemodialysis because of insufficient renal donors. In the current study, we aimed to compare patency rates of AV fistulae created with or without the endothelial protection solution. Methods: This single-center case-control study was conducted between August 2018 and August 2019. Patients with end-stage renal disease requiring AV fistula access for hemodialysis (n= 49) were included in the study and divided into two groups. During the creation of an AV fistulae, endothelial protection solution was used in 27 patients, who constituted Group A, and not used in 22 patients, who were included in Group B (the control group). All fistulae anastomoses were performed by the same surgical team. The demographical data, maturation time, mean flow volume, complications, basal metabolism index (BMI), and patency rates at the 3rd and 6th months were compared. Results: There was no significant difference between the two groups regarding demographical findings (p>0.05). The patency rates were higher in group A at both the 3rd and 6th months (96% and 93%) when compared with group B (64% and 27%) (P<0.05). Conclusion: AV fistulae created with endothelial protection solution has higher patency rates compared to conventionally created AV fistulae.
Amaç: Son dönem böbrek hastalığı olan hastalar, hemodiyaliz için doğru ve etkili damar erişimine ihtiyaç duymaktadır. Böbrek nakli, hemodiyaliz gereksinimi olmadan yaşamın sürdürülmesini sağlayan kesin tedavi yöntemi olsa da, yetersiz böbrek donörü nedeniyle uzun süreli hemodiyalizin sürdürülmesinde en sık kullanılan yöntem arteriyovenöz (AV) fistüldür. Bu çalışmada, endotel koruma solüsyonu ile veya solüsyonsuz oluşturulan AV fistülün açıklık oranlarını karşılaştırmayı amaçladık. Yöntemler: Bu tek merkezli vaka control çalışması Ağustos 2018 ile Ağustos 2019 arasında gerçekleştirilmiştir. Hemodiyaliz için son dönem böbrek hastalığı olan hastalar (toplam 49 hasta) çalışmaya dahil edilmiştir. Hastalar grup A (endotel koruma solüsyonu ile oluşturulan AV fistüller çalışma grubu olarak, n=27) ve grup B (endotel koruma solüsyonu olmadan oluşturulan AV fistüller control grubu olarak, n=22) olarak iki gruba ayrıldı. Tüm fistül anastomozları aynı cerrahi ekip tarafından yapıldı. 3. ve 6. aydaki demografik veriler, olgunlaşma süresi, ortalama akış hacmi, komplikasyonlar, bazal metabolizma indeksi (VKİ) ve açıklık oranları karşılaştırıldı. Bulgular: Demografik bulgular açısından iki grup arasında fark yoktu (P>0,05). Grup A'da 3. ve 6. ayda (%96 ve %93) B grubuna (%64 ve %27) göre daha yüksek açıklık oranları saptandı (P<0,05). Sonuç: Endotelyal koruma solüsyonu ile oluşturulan AV fistül, geleneksel AV fistül oluşturma ile karşılaştırıldığında daha yüksek açıklık oranlarına sahip gibi görünmektedir.
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Primary Language en
Subjects Cardiac and Cardiovascular Systems
Journal Section Research article
Authors

Orcid: 0000-0002-9814-7056
Author: Emced KHALİL (Primary Author)
Institution: ORDU ÜNİVERSİTESİ
Country: Turkey


Orcid: 0000-0003-3370-9879
Author: Çağrı AKALIN
Institution: ordu üniversitesi eğitim ve araştırma hastanei
Country: Turkey


Supporting Institution yok
Project Number ..
Thanks t
Dates

Publication Date : September 1, 2020

Bibtex @research article { josam788906, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {716 - 719}, doi = {10.28982/josam.788906}, title = {Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation}, key = {cite}, author = {Khali̇l, Emced and Akalın, Çağrı} }
APA Khali̇l, E , Akalın, Ç . (2020). Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation . Journal of Surgery and Medicine , 4 (9) , 716-719 . DOI: 10.28982/josam.788906
MLA Khali̇l, E , Akalın, Ç . "Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation" . Journal of Surgery and Medicine 4 (2020 ): 716-719 <http://jsurgmed.com/en/pub/issue/56766/788906>
Chicago Khali̇l, E , Akalın, Ç . "Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation". Journal of Surgery and Medicine 4 (2020 ): 716-719
RIS TY - JOUR T1 - Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation AU - Emced Khali̇l , Çağrı Akalın Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.788906 DO - 10.28982/josam.788906 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 716 EP - 719 VL - 4 IS - 9 SN - -2602-2079 M3 - doi: 10.28982/josam.788906 UR - https://doi.org/10.28982/josam.788906 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation %A Emced Khali̇l , Çağrı Akalın %T Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 9 %R doi: 10.28982/josam.788906 %U 10.28982/josam.788906
ISNAD Khali̇l, Emced , Akalın, Çağrı . "Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation". Journal of Surgery and Medicine 4 / 9 (September 2020): 716-719 . https://doi.org/10.28982/josam.788906
AMA Khali̇l E , Akalın Ç . Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation. J Surg Med. 2020; 4(9): 716-719.
Vancouver Khali̇l E , Akalın Ç . Effectiveness and safety of using a novel endothelial damage inhibitor in arteriovenous fistula formation. Journal of Surgery and Medicine. 2020; 4(9): 716-719.