Year 2020, Volume 4 , Issue 8, Pages 689 - 692 2020-08-01

Tadalafil ve telmisartanın bleomisine bağlı akciğer fibrozisi üzerindeki etkilerinin incelenmesi
Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats

İ̇lke Onur KAZAZ KAZAZ [1] , Güner Kemal ÖZGÜR [2] , Ümi̇t ÇOBANOĞLU [3] , Nuri İ̇hsan KALYONCU [4] , Ersagun KARAGÜZEL [5] , Murat TOPBAŞ [6] , Hüseyin EREN [7] , Seher Nazlı KAZAZ [8] , Rasin ÖZYAVUZ [9]


Amaç: Farklı malignitelerin tedavisinde kullanılan bir antitümör ilaç olan bleomisin ile ilişkili pulmoner toksisite, önemli bir sorundur ve bu toksisiteyi önleyecek molekülleri bulmak için çalışmalar devam etmektedir. Bu deneysel çalışmada, ratlarda, bleomisinle indüklenen akciğer fibrozisinde telmisartan ve tadalafilin etkinliğini araştırmayı amaçladık. Yöntemler: 32 erkek rat dört gruba ayrıldı: Kontrol grubu, Bleomisin grubu, Bleomisin+Tadalafil grubu, Bleomisin+Telmisartan grubu. Akciğer fibrozisi intratrakeal bleomisin uygulaması ile oluşturulurken aynı prosedür kontrol grubunda bleomisin yerine salin kullanılarak uygulandı. Tadalafil ve telmisartan gruplara göre 14 gün boyunca orogastrik kateter vasıtasıyla verildi. Doku MDA düzeyleri kalorimetrik yöntemler kullanılarak ölçüldü. Masson trikrom boyama uygulanarak histolojik değerlendirme yapıldı. Bulgular: Bleomisin+tadalafil ve bleomisin+telmisartan gruplarının fibrozis skorları bleomisin grubuna göre daha düşüktü. Gruplar arasında MDA düzeyleri açısından farklılık görülmedi. Sonuç: Tadalafil ve telmisartanın bleomisine bağlı artan fibrozis skorlarını düşürdüğü ve pulmoner toksisitenin birden fazla süreçle ilişkili olduğu ve önlenebilir olduğu kanısındayız.
Aim: Pulmonary toxicity related to bleomycin, an antitumor drug used in the treatment of several malignancies, is a challenge, and studies to find out molecules to prevent it are ongoing. In this study, we aimed to investigate the effectiveness of telmisartan and tadalafil in an experimental rat model of bleomycin-induced lung fibrosis. Methods: A total of 32 male rats were divided into four groups: Control group, Bleomycin group, Bleomycin-plus-Tadalafil group and Bleomycin-plus-Telmisartan group. Lung fibrosis was achieved by intratracheal administration of bleomycin, and the same procedure was performed to the control group, but saline was substituted for bleomycin. Tadalafil and telmisartan were administered with an orogastric catheter for 14 days. Tissue malondialdehyde levels (MDA) were determined using colorimetric methods. Masson’s trichrome staining was used in the histological examination of the tissue samples. Results: The fibrosis scores of bleomycin-plus-tadalafil and bleomycin-plus-telmisartan groups were lower than that of the bleomycin group (P=0.007 and P=0.007, respectively). MDA levels did not differ among study groups. Conclusion: Tadalafil and telmisartan were found to decrease fibrosis scores, which were increased with bleomycin, concluding that pulmonary toxicity was related to multiple processes and preventable.
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Primary Language en
Subjects Oncology
Journal Section Research article
Authors

Orcid: 0000-0002-2106-0016
Author: İ̇lke Onur KAZAZ KAZAZ (Primary Author)
Institution: KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY
Country: Turkey


Orcid: 0000-0002-6872-2355
Author: Güner Kemal ÖZGÜR
Institution: KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY
Country: Turkey


Orcid: 0000-0001-6429-427X
Author: Ümi̇t ÇOBANOĞLU
Institution: KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, DEPARTMENT OF MEDICAL PATHOLOGY
Country: Turkey


Orcid: 0000-0002-7362-6560
Author: Nuri İ̇hsan KALYONCU
Institution: KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF MEDICAL PHARMACOLOGY
Country: Turkey


Orcid: 0000-0003-4270-0147
Author: Ersagun KARAGÜZEL
Institution: KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY
Country: Turkey


Orcid: 0000-0003-4047-4027
Author: Murat TOPBAŞ
Institution: KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF PUBLIC HEALTH
Country: Turkey


Orcid: 0000-0002-1406-8781
Author: Hüseyin EREN
Institution: RECEP TAYYIP ERDOGAN UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY
Country: Turkey


Orcid: 0000-0002-8181-000X
Author: Seher Nazlı KAZAZ
Institution: KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF INTERNAL MEDICINE
Country: Turkey


Orcid: 0000-0002-7362-6560
Author: Rasin ÖZYAVUZ
Institution: KARADENIZ TECHNICAL UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF SURGICAL MEDICAL SCIENCES, THE DEPARTMENT OF UROLOGY
Country: Turkey


Dates

Publication Date : August 1, 2020

Bibtex @research article { josam780681, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {689 - 692}, doi = {10.28982/josam.780681}, title = {Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats}, key = {cite}, author = {Kazaz, İ̇lke Onur and Özgür, Güner Kemal and Çobanoğlu, Ümi̇t and Kalyoncu, Nuri İ̇hsan and Karagüzel, Ersagun and Topbaş, Murat and Eren, Hüseyin and Kazaz, Seher Nazlı and Özyavuz, Rasin} }
APA Kazaz, İ , Özgür, G , Çobanoğlu, Ü , Kalyoncu, N , Karagüzel, E , Topbaş, M , Eren, H , Kazaz, S , Özyavuz, R . (2020). Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats . Journal of Surgery and Medicine , 4 (8) , 689-692 . DOI: 10.28982/josam.780681
MLA Kazaz, İ , Özgür, G , Çobanoğlu, Ü , Kalyoncu, N , Karagüzel, E , Topbaş, M , Eren, H , Kazaz, S , Özyavuz, R . "Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats" . Journal of Surgery and Medicine 4 (2020 ): 689-692 <http://jsurgmed.com/en/pub/issue/56401/780681>
Chicago Kazaz, İ , Özgür, G , Çobanoğlu, Ü , Kalyoncu, N , Karagüzel, E , Topbaş, M , Eren, H , Kazaz, S , Özyavuz, R . "Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats". Journal of Surgery and Medicine 4 (2020 ): 689-692
RIS TY - JOUR T1 - Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats AU - İ̇lke Onur Kazaz , Güner Kemal Özgür , Ümi̇t Çobanoğlu , Nuri İ̇hsan Kalyoncu , Ersagun Karagüzel , Murat Topbaş , Hüseyin Eren , Seher Nazlı Kazaz , Rasin Özyavuz Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.780681 DO - 10.28982/josam.780681 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 689 EP - 692 VL - 4 IS - 8 SN - -2602-2079 M3 - doi: 10.28982/josam.780681 UR - https://doi.org/10.28982/josam.780681 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats %A İ̇lke Onur Kazaz , Güner Kemal Özgür , Ümi̇t Çobanoğlu , Nuri İ̇hsan Kalyoncu , Ersagun Karagüzel , Murat Topbaş , Hüseyin Eren , Seher Nazlı Kazaz , Rasin Özyavuz %T Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 8 %R doi: 10.28982/josam.780681 %U 10.28982/josam.780681
ISNAD Kazaz, İ̇lke Onur , Özgür, Güner Kemal , Çobanoğlu, Ümi̇t , Kalyoncu, Nuri İ̇hsan , Karagüzel, Ersagun , Topbaş, Murat , Eren, Hüseyin , Kazaz, Seher Nazlı , Özyavuz, Rasin . "Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats". Journal of Surgery and Medicine 4 / 8 (August 2020): 689-692 . https://doi.org/10.28982/josam.780681
AMA Kazaz İ , Özgür G , Çobanoğlu Ü , Kalyoncu N , Karagüzel E , Topbaş M , Eren H , Kazaz S , Özyavuz R . Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats. J Surg Med. 2020; 4(8): 689-692.
Vancouver Kazaz İ , Özgür G , Çobanoğlu Ü , Kalyoncu N , Karagüzel E , Topbaş M , Eren H , Kazaz S , Özyavuz R . Investigation of the effects of tadalafil and telmisartan in bleomycin-induced pulmonary fibrosis on rats. Journal of Surgery and Medicine. 2020; 4(8): 689-692.