Year 2020, Volume 4 , Issue 8, Pages 640 - 644 2020-08-01

İlk trimester hemoglobin değerinin olumsuz gebelik sonuçları üzerine etkileri
The effects of first-trimester hemoglobin on adverse pregnancy outcomes

Gülten ÖZGEN [1] , Gültekin ADANAS [2] , Levent ÖZGEN [3]


Amaç: Literatürde yapılan çalışmalarda farklı hemoglobin (Hb) düzeylerinin postpartum hemoraji, gebelik ile indüklenen hipertansiyon, intrauterin gelişme geriliği, gestasyonel diabetes mellitus ve perinatal mortalite gibi olumsuz gebelik sonuçları ile ilişkisi gösterilmiştir. Bu çalışmanın amacı gebeliğin ilk üç ayında ölçülen hemoglobin (Hb) düzeylerinin gebelik sonuçları üzerindeki etkilerini araştırmak ve Hb'nin olumsuz gebelik sonuçları üzerindeki prediktif değerini belirlemektir. Yöntemler: Bu tek merkezli, retrospektif çalışma, kadın hastalıkları ve jinekoloji kliniğimizde teşhis, takip ve doğumları yapılan toplam 8.916 gebeyi kapsamaktadır. Hastalar Hb düzeylerine göre anemik (Hb<11 g/dL, n=1.846), normal (Hb 11-12,5 g/dL, n=4.898) ve yüksek (Hb ≥12,5 g/dL, n=2.172) olmak üzere üç gruba ayrıldı. Hastaların demografik ve klinik özellikleri hastane kayıtlarından elde edilerek olumsuz gebelik sonuçları kaydedildi. Bulgular: Hastaların ortalama yaşı 27,50 (4,45) yıl ve vücut kitle indeksi değeri (VKİ) değeri 25,03 (3,39) kg/m2 idi. Ortalama Hb düzeyi 11,83 (0,88) g/dL ve ortalama hematokrit değeri %36 (%2,75)'ti. Hemoglobin seviyelerinden bağımsız olarak tüm çalışma grubunda gebelik kaybı %6,5, bozulmuş glukoz toleransı %4,9, gestasyonel diabetes mellitus %5,1, gebelik ile indüklenen hipertansiyon %7,4, erken doğum %3,8, yenidoğan yoğun bakım ünitesine duyulan ihtiyaç %3,5, düşük APGAR skorları %3,8, plasenta previa %2,4, plasental ablasyon %1,3, sezaryen (C/S) doğum %39,3, düşük doğum ağırlığı %5,9 ve erken membran rüptürü %9,7 oranında saptandı. Hemoglobin seviyeleri ve olumsuz gebelik sonuçlarını oluşturan değişkenler açısından anlamlı bir fark yoktu (Tümü için P>0,05). Sonuç: Çalışmamızda ilk trimesterde ölçülen Hb konsantrasyonlarına göre ayrılan gruplar arasında olumsuz gebelik sonuçları açısından anlamlı bir farklılık saptanmadı.
Aim: Previous studies have demonstrated that variable hemoglobin levels are associated with adverse pregnancy outcomes such as postpartum hemorrhage, pregnancy-induced hypertension, intrauterine growth restriction, gestational diabetes mellitus and perinatal mortality. Here, we aimed to investigate the effects of hemoglobin (Hb) levels measured in the first trimester of pregnancy on pregnancy outcomes and identify the predictive value of Hb on adverse pregnancy outcomes. Methods: This single-center, retrospective study included a total of 8,916 pregnant women who were diagnosed, followed, and delivered their babies in our Obstetrics and Gynecology clinic. The patients were divided into three groups according to their Hb levels as anemic (Hb <11 g/dL, n=1,846), normal (Hb <12.5 g/dL, n=4,898), and elevated (Hb ≥12.5 g/dL, n=2,172). Demographic and clinical features of the patients were obtained from hospital records. Adverse pregnancy outcomes were also noted. Results: The mean age of the patients was 27.50 (4.45) years and BMI value was 25.03 (3.39) kg/m2. The mean Hb level was 11.83 (0.88) g/dL and the mean hematocrit value was 36.004 (2.75%). Irrespective of Hb levels, among all patients, rate of pregnancy loss was 6.5%, rate of impaired glucose tolerance, 4.9%, gestational diabetes mellitus, 5.1%, pregnancy-induced hypertension, 7.4%, preterm birth 3.8%. The rate of newborns in need of neonatal intensive care unit was 3.5%, while 3.8% were born with low APGAR scores. Placenta previa was observed in 2.4% of patients, and placental abruption was seen in 1.3%. About 39.3% had a cesarean-section (C/S) delivery, 5.9% gave birth to low birth-weight neonates, and premature rupture of membranes was observed in 9.7% patients. There were no significant differences with respect to adverse pregnancy outcomes between the three groups (P>0.05 for all). Conclusion: Our study results showed no significant differences between the three groups categorized by Hb concentrations measured in the first trimester in terms of adverse pregnancy outcomes.
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Primary Language en
Subjects Obstetrics and Gynecology
Journal Section Research article
Authors

Orcid: 0000-0002-7788-7583
Author: Gülten ÖZGEN (Primary Author)
Institution: Bursa sağlık bilimleri üniversitesi yüksek ihtisas eğitim ve araştırma hastanesi, Kadın Hastalıkları ve Doğum Kiniği
Country: Turkey


Orcid: 0000-0002-9113-9846
Author: Gültekin ADANAS
Institution: Bursa Şehir Hastanesi, Kadın Hastalıkları ve Doğum Kliniği
Country: Turkey


Orcid: 0000-0003-0070-2646
Author: Levent ÖZGEN
Institution: Bursa Şehir Hastanesi, Kadın Hastalıkları Ve Doğum Kliniği
Country: Turkey


Dates

Publication Date : August 1, 2020

Bibtex @research article { josam773306, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {640 - 644}, doi = {10.28982/josam.773306}, title = {The effects of first-trimester hemoglobin on adverse pregnancy outcomes}, key = {cite}, author = {Özgen, Gülten and Adanas, Gültekin and Özgen, Levent} }
APA Özgen, G , Adanas, G , Özgen, L . (2020). The effects of first-trimester hemoglobin on adverse pregnancy outcomes . Journal of Surgery and Medicine , 4 (8) , 640-644 . DOI: 10.28982/josam.773306
MLA Özgen, G , Adanas, G , Özgen, L . "The effects of first-trimester hemoglobin on adverse pregnancy outcomes" . Journal of Surgery and Medicine 4 (2020 ): 640-644 <http://jsurgmed.com/en/pub/issue/56401/773306>
Chicago Özgen, G , Adanas, G , Özgen, L . "The effects of first-trimester hemoglobin on adverse pregnancy outcomes". Journal of Surgery and Medicine 4 (2020 ): 640-644
RIS TY - JOUR T1 - The effects of first-trimester hemoglobin on adverse pregnancy outcomes AU - Gülten Özgen , Gültekin Adanas , Levent Özgen Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.773306 DO - 10.28982/josam.773306 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 640 EP - 644 VL - 4 IS - 8 SN - -2602-2079 M3 - doi: 10.28982/josam.773306 UR - https://doi.org/10.28982/josam.773306 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine The effects of first-trimester hemoglobin on adverse pregnancy outcomes %A Gülten Özgen , Gültekin Adanas , Levent Özgen %T The effects of first-trimester hemoglobin on adverse pregnancy outcomes %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 8 %R doi: 10.28982/josam.773306 %U 10.28982/josam.773306
ISNAD Özgen, Gülten , Adanas, Gültekin , Özgen, Levent . "The effects of first-trimester hemoglobin on adverse pregnancy outcomes". Journal of Surgery and Medicine 4 / 8 (August 2020): 640-644 . https://doi.org/10.28982/josam.773306
AMA Özgen G , Adanas G , Özgen L . The effects of first-trimester hemoglobin on adverse pregnancy outcomes. J Surg Med. 2020; 4(8): 640-644.
Vancouver Özgen G , Adanas G , Özgen L . The effects of first-trimester hemoglobin on adverse pregnancy outcomes. Journal of Surgery and Medicine. 2020; 4(8): 640-644.