Yıl 2020, Cilt 4 , Sayı 4, Sayfalar 271 - 275 2020-04-01

Kırmızı kan hücresi dağılım genişliği (RDW) ülseratif kolit hastalarında klinik ve endoskopik aktiviteyi tahmin edebilir mi?
Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients?

Hüseyin PÜLAT [1] , Serkan YALAKİ [2]


Amaç: Ülseratif kolitin (ÜK) hastalık aktivitesi ve şiddetine göre sınıflandırılması klinik uygulamada önemlidir, çünkü hastanın yönetimini belirler. Bu çalışmada, ÜK hastalarında kırmızı kan hücresi dağılım genişliği (RDW) ile klinik aktivite indeksi (KAİ) ve mukozal hastalığa göre hastalık şiddetini belirleyen endoskopik aktivite indeksleri (EAİ) arasındaki ilişkiyi araştırmayı amaçladık.
Yöntemler: Araştırma bir vaka kontrol çalışması olarak planlandı. ÜK tanısı alan 99 hasta klinik ve endoskopik aktivitelerine göre aktif hastalık grubu ve remisyon grubu olmak üzere iki gruba ayrıldı. Kolonoskopi yapılan ve normal bulunan 56 kişiden yaş ve cinsiyet uyumlu kontrol grupları oluşturuldu.
Bulgular: Serum RDW düzeyleri ÜK grubunda anlamlı olarak yüksekti (P<0,001). RDW ile yapılan post-hoc karşılaştırmalarda, kontrol grubu ile aktif hastalık grupları arasında istatistiksel olarak anlamlı farklılıklar gözlenmiştir (P<0,001). Bununla birlikte, RDW değerleri klinik ve endoskopik aktivitenin belirlenmesinde, aktif hastalık ve remisyon grupları arasında anlamlı değildi (sırasıyla P=0,05 ve P=0,09). Klinik ve endoskopik aktivite indekslerini tahmin ederken, RDW'nin cut-off değerleri sırasıyla 14,25 (%66 duyarlılık ve %72 özgüllük) ve 13,75 (%64 duyarlılık ve %62 özgüllük) idi.
Sonuç: Bu çalışma, RDW'nin ülseratif kolitte hastalık aktivitesi için bir belirteç olarak kullanılabileceğini gösterdi, ancak remisyon ve aktif hastalık ayrımında aynı etkinliği göstermedi.

Aim: Classification of ulcerative colitis (UC) according to disease activity and severity is important in clinical practice for it determines the management of the patient. In this study, we aimed to investigate the relationship between red blood cell distribution width (RDW) and clinical activity index (CAI) in UC patients as well as endoscopic activity indexes (EIA) that determine disease severity relative to mucosal disease.
Methods: This research was planned as a case-control study. Ninety-nine patients diagnosed with UC were divided an active disease group and a remission group according to their clinical and endoscopic findings. Age and gender-matched control groups were formed from 56 individuals with normal colonoscopic findings.
Results: Serum RDW levels were significantly higher in the UC group (P<0.001). In post-hoc comparisons, a statistically significant difference was observed between the control group and active disease groups (P<0.001). However, RDW values did not significantly predict clinical and endoscopic activity in either the active disease or the remission groups (P=0.05 and P=0.09, respectively). In predicting clinical and endoscopic activity indices, the cut-off values of RDW were 14.25 (66% sensitivity and 72% specificity) and 13.75 (64% sensitivity and 62% specificity), respectively.
Conclusion: This study showed that RDW can be used as a marker for disease activity in ulcerative colitis, but it did not show the same efficacy in remission and active disease distinction.
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Birincil Dil en
Konular Gastroenteroloji ve Hepatoloji
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0003-0635-3387
Yazar: Hüseyin PÜLAT
Kurum: Mersin City Training and Research Hospital
Ülke: Turkey


Orcid: 0000-0001-8137-0924
Yazar: Serkan YALAKİ (Sorumlu Yazar)
Kurum: Mersin City Training and Research Hospital
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Nisan 2020

Bibtex @araştırma makalesi { josam712289, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {271 - 275}, doi = {10.28982/josam.712289}, title = {Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients?}, key = {cite}, author = {Pülat, Hüseyin and Yalaki, Serkan} }
APA Pülat, H , Yalaki, S . (2020). Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients? . Journal of Surgery and Medicine , 4 (4) , 271-275 . DOI: 10.28982/josam.712289
MLA Pülat, H , Yalaki, S . "Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients?" . Journal of Surgery and Medicine 4 (2020 ): 271-275 <https://jsurgmed.com/tr/pub/issue/53710/712289>
Chicago Pülat, H , Yalaki, S . "Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients?". Journal of Surgery and Medicine 4 (2020 ): 271-275
RIS TY - JOUR T1 - Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients? AU - Hüseyin Pülat , Serkan Yalaki Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.712289 DO - 10.28982/josam.712289 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 271 EP - 275 VL - 4 IS - 4 SN - -2602-2079 M3 - doi: 10.28982/josam.712289 UR - https://doi.org/10.28982/josam.712289 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients? %A Hüseyin Pülat , Serkan Yalaki %T Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients? %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 4 %R doi: 10.28982/josam.712289 %U 10.28982/josam.712289
ISNAD Pülat, Hüseyin , Yalaki, Serkan . "Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients?". Journal of Surgery and Medicine 4 / 4 (Nisan 2020): 271-275 . https://doi.org/10.28982/josam.712289
AMA Pülat H , Yalaki S . Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients?. J Surg Med. 2020; 4(4): 271-275.
Vancouver Pülat H , Yalaki S . Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients?. Journal of Surgery and Medicine. 2020; 4(4): 271-275.
IEEE H. Pülat ve S. Yalaki , "Can red blood cell distribution width (RDW) predict clinical and endoscopic activity in ulcerative colitis patients?", Journal of Surgery and Medicine, c. 4, sayı. 4, ss. 271-275, Nis. 2020, doi:10.28982/josam.712289