Yıl 2019, Cilt 3 , Sayı 6, Sayfalar 441 - 446 2019-06-28

Chiari tip 1 malformasyonunda morfolojik ölçümlerin semptomlar üzerine etkisi
Impact of morphological measurements on symptoms in Chiari malformation type 1

Rasime Pelin KAVAK [1] , Meltem ÖZDEMİR [2] , Mehmet SORAR [3]


Amaç: Chiari Tip 1 malformasyonu (CM1) serebellar tonsil veya tonsillerin spinal kanala herniasyonu sonucu ortaya çıkan bir patolojidir. CM1 hastalarında kraniyumun morfolojik ölçümlerinin semptomlar üzerindeki etkisini incelemeyi amaçladık.

Yöntemler: Çalışmamız tek merkezde retrospektif vaka-kontrol çalışması olarak tasarlandı. Klinik ve muayene bulguları sonucunda CM1 olduğu düşünülen tanıyı kesinleştirmek veya dışlamak için beyin manyetik rezonans görüntüleme (MRG) yapılan, yaşları 18-70 arasında 2309 hasta değerlendirildi. Kranium, morfolojik ölçümleri, herniasyon miktarı, hastaların semptomları ve modifiye Asgari skoru retrospektif olarak incelendi.

Bulgular: MRG değerlendirilmesinden sonra kesin CM1 tanısı alanlar çalışma grubu (n=212) ve diğerleri kontrol grubu (n=2097) olarak hastalar sınıflandırıldı. Çalışma grubunda maksimum kranial uzunluk, maksimum kranial yükseklik, supraocciput uzunluğu, posterior cranial fossa anteroposterior (PCF) uzunluğu kısa iken, foramen magnumun sagital çapı ve serebrum’un en uzun ön arka çapı uzun idi. (hepsi için P<0,001). Çalışma grubunda tentorium serebelli eğimi belirgin olarak düşük saptandı (P<0,001). En sık görülen semptom baş ağrısıydı (%92). Herniasyon miktarı maksimum kranial uzunluk ve maksimum kranial yükseklik ile negatif korelasyon (sırası ile r=-0,184, P=0,07; r=-0,158, P=0,022) ve modifiye Asgari skoru ile pozitif korelasyon göstermekte idi (r=0,598; P<0,001).

Sonuç: Kraniyumun morfolojik ölçümleri CM1 hastalarının semptomlarını üzerinde etkilidir.

Aim: Chiari malformation Type 1 (CM1) is a pathology resulting from herniation of cerebellar tonsils or tonsils into the spinal canal. We aimed to examine the impact of the cranium’s morphological measurements on the symptoms with CM1 patients.

Methods: This research was designed as a retrospective case-control study in a single-center. 2309 patients aged between 18-70 who underwent brain magnetic resonance imaging (MRI) to confirm or exclude the diagnosis of CM1 as a result of clinical and examination findings were evaluated. Cranium’s morphological measurements, the amount of herniation, patient’s symptoms, and the modified Asgari score were retrospectively assessed. 

Results: Patients with a final diagnosis of CM1 after the MRI evaluation were classified as study group (n=212), and the others control group (n=2097). The maximum cranial length, maximum cranial height, supra occiput length, posterior cranial fossa (PCF) anteroposterior length, in the study group were shorter, whereas the sagittal diameter of the foramen magnum and the longest anteroposterior diameter of the cerebrum were longer (P<0.001 for all mentioned comparisons). Tentorium cerebelli slope was found to be significantly lower in the study group (P<0.001). The most prevalent symptoms were a headache (92%). The herniation amount had a negative correlation with maximum cranial length and maximum cranial height (r=-0.184, P=0.07; r=-0.158 and P=0.022, respectively) and a positive correlation with the modified Asgari score (r=0.598; P<0.001).

Conclusion: The cranium’s morphological measurements have an impact on the symptoms of patients with CM1.

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Birincil Dil en
Konular Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0000-0001-9782
Yazar: Rasime Pelin KAVAK (Sorumlu Yazar)
Kurum: University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Radiology Department, Ankara, Turkey
Ülke: Turkey


Orcid: 0000-0002-7388-2871
Yazar: Meltem ÖZDEMİR
Kurum: University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Radiology Department, Ankara, Turkey
Ülke: Turkey


Orcid: 0000-0002-6933-7627
Yazar: Mehmet SORAR
Kurum: University of Health Sciences Dışkapi Yıldırım Beyazıt Training and Research Hospital, Department of Neurosurgery, Ankara, Turkey
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 28 Haziran 2019

Bibtex @araştırma makalesi { josam572881, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2019}, volume = {3}, pages = {441 - 446}, doi = {10.28982/josam.572881}, title = {Impact of morphological measurements on symptoms in Chiari malformation type 1}, key = {cite}, author = {Kavak, Rasime Pelin and Özdemir, Meltem and Sorar, Mehmet} }
APA Kavak, R , Özdemir, M , Sorar, M . (2019). Impact of morphological measurements on symptoms in Chiari malformation type 1 . Journal of Surgery and Medicine , 3 (6) , 441-446 . DOI: 10.28982/josam.572881
MLA Kavak, R , Özdemir, M , Sorar, M . "Impact of morphological measurements on symptoms in Chiari malformation type 1" . Journal of Surgery and Medicine 3 (2019 ): 441-446 <https://jsurgmed.com/tr/pub/issue/45558/572881>
Chicago Kavak, R , Özdemir, M , Sorar, M . "Impact of morphological measurements on symptoms in Chiari malformation type 1". Journal of Surgery and Medicine 3 (2019 ): 441-446
RIS TY - JOUR T1 - Impact of morphological measurements on symptoms in Chiari malformation type 1 AU - Rasime Pelin Kavak , Meltem Özdemir , Mehmet Sorar Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.572881 DO - 10.28982/josam.572881 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 441 EP - 446 VL - 3 IS - 6 SN - -2602-2079 M3 - doi: 10.28982/josam.572881 UR - https://doi.org/10.28982/josam.572881 Y2 - 2019 ER -
EndNote %0 Journal of Surgery and Medicine Impact of morphological measurements on symptoms in Chiari malformation type 1 %A Rasime Pelin Kavak , Meltem Özdemir , Mehmet Sorar %T Impact of morphological measurements on symptoms in Chiari malformation type 1 %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 6 %R doi: 10.28982/josam.572881 %U 10.28982/josam.572881
ISNAD Kavak, Rasime Pelin , Özdemir, Meltem , Sorar, Mehmet . "Impact of morphological measurements on symptoms in Chiari malformation type 1". Journal of Surgery and Medicine 3 / 6 (Haziran 2019): 441-446 . https://doi.org/10.28982/josam.572881
AMA Kavak R , Özdemir M , Sorar M . Impact of morphological measurements on symptoms in Chiari malformation type 1. J Surg Med. 2019; 3(6): 441-446.
Vancouver Kavak R , Özdemir M , Sorar M . Impact of morphological measurements on symptoms in Chiari malformation type 1. Journal of Surgery and Medicine. 2019; 3(6): 441-446.
IEEE R. Kavak , M. Özdemir ve M. Sorar , "Impact of morphological measurements on symptoms in Chiari malformation type 1", Journal of Surgery and Medicine, c. 3, sayı. 6, ss. 441-446, Haz. 2019, doi:10.28982/josam.572881