Research Article
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Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome

Year 2022, Volume 6, Issue 4, 428 - 431, 01.04.2022
https://doi.org/10.28982/josam.929820

Abstract

Background/Aim: Fibromyalgia syndrome (FMS) has been linked to a genetic background. Although there are conflicting results, it has been suggested that cytokines play a role in FMS etiology. Interleukin (IL)1β is a cytokine that has been linked to FMS symptoms and has been detected in the skin of FMS patients. We aimed to determine the possible relationship between IL1β -31 and IL1β -511 polymorphisms in FMS. Methods: In this cross-sectional study, we included patients who were diagnosed with FMS according to the American College of Rheumatology classification criteria. IL1β -31 (rs 1143627) and IL1β -511 (rs 16944) polymorphism genotyping was conducted in FMS patients (n=33) and healthy controls (n=41) using real-time polymerase chain reaction (RT-PCR). Results: IL1β -511 variations in patients with FMS and control groups were significantly different (P=0.010). The frequency of the IL1β -511 heterozygote AG genotype was significantly higher in controls (P=0.028). Additionally, the frequency of the IL1β -511 wild type A allele was significantly higher in the control group (P=0.003). The IL1β -31 genotypes and allele frequencies were not significantly different between the groups. Conclusion: The IL1β -511 wild type A allele could be a risk-reducing factor for FMS. The present study suggests that genetic variations of the IL1β gene could play an important role in FMS etiology.

References

  • 1. Bellato E, Marini E, Castoldi F, Barbasetti N, Mattei L, Bonasia DE, et al. Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment. Pain Res Treat. 2012;2012:1-17.
  • 2. Ablin JN, Buskila D. Update on the genetics of the fibromyalgia syndrome. Best Pract Res Clin Rheumatol. 2015;29:20-8.
  • 3. Clauw DJ. Fibromyalgia: A clinical review. JAMA. 2014;311(15):1547-55.
  • 4. Knezevic NN, Tverdohleb T, Knezevic I, Candido KD. The role of genetic polymorphism in chronic pain patients. Int J Mol Sci. 2018;19(6):1707.
  • 5. Feng J, Zhang Z, Wu X, Mao A, Chang F, Deng X, et al. Discovery of potential new gene variants and inflammatory cytokine associations with fibromyalgia syndrome by whole exome sequencing. PLoS One. 2013;8(6):e65033.
  • 6. Mendieta D, De la Cruz-Aguilera DL, Barrera-Villalpando MI, Becerril-Villanueva E, Arreola R, Hernández-Ferreira E, et al. IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients. J Neuroimmunol. 2016;290:22–5.
  • 7. Malhotra D, Saxena AK, Dar SA, Kumar V, Nasare N, Tripathi AK, et al. Evaluation of cytokine levels in fibromyalgia syndrome patients and its relationship to the severity of chronic pain. J Musculoskelet Pain. 2012;20:164–9.
  • 8. Bote ME, García JJ, Hinchado MD, Ortega E. Inflammatory/stress feedback dysregulation in women with fibromyalgia.Neuroimmunomodulation. 2012;19:343–51.
  • 9. Imamura M, Targino RA, Hsing WT, Imamura S, Azevedo RS, Boas LS, et al. Concentration of cytokines in patients with osteoarthritis of the knee and fibromyalgia. Clin Interv Aging. 2014;9:939–44.
  • 10. Ernberg E, Christidis B, Ghafouri B, Bileviciute-Ljungar I, Löfgren M, Bjersing J, et al. Plasma cytokine levels in fibromyalgia and their response to 15 weeks of progressive resistance exercise or relaxation therapy. Mediators of Inflamm. 2018;2018:3985154.
  • 11. Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH. Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology. 2001;40:743-9.
  • 12. Wang H, Moser M, Schiltenwolf M, Buchner M. Circulating cytokine levels compared to pain in patients with fibromyalgia-a prospective longitudinal study over 6 months. J Rheumatol. 2008;35:1366-70.
  • 13. Cetin B, Gulec H, Toktas HE, Ulutas O, Yilmaz SG, Isbir T. Objective measures of sleep in fibromyalgia syndrome: Relationship to clinical, psychiatric, and immunological variables. Psychiatry Research. 2018;263:125-9.
  • 14. Jewett KA, Krueger JM. Humoral sleep regulation; interleukin-1 and tumor necrosis factor. Vitam Horm. 2012;89:241-57.
  • 15. Lorton D, Lubahn CL, Estus C, Millar BA, Carter JL, Wood CA, et al. Bidirectional communication between the brain and the immune system: implications for physiological sleep and disorders with disrupted sleep. Neuroimmunomodulation. 2006;13:357-74.
  • 16. Menzies V, Lyon DE. Integrated review of the association of cytokines with fibromylgia and fibromyalgia core symptoms. Biological research for nursing. 2010;11(4):387-94.
  • 17. Salemi S, Rethage J, Wollina U, Michel BA, Gay RE, Gay S, Sprott H. Detection of interleukin 1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia. J Rheumatol. 2003;30(1):146-50.
  • 18. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Hauser W, Katz RL, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319-29.
  • 19. Sumpton JE, Moulin DE. Fibromyalgia. Handb Clin Neurol. 2014;119:513-27.
  • 20. Bazzichi L, Rossi A, Massimetti G, Giannaccini G, Guiliano T, De Feo F, et al. Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Clin Exp Rheumatol. 2007;25(2):225-30.
  • 21. Rodriguez-Pinto I, Agmon-Levin N, Howard A, Shoenfeld Y. Fibromyalgia and cytokines. Immunol Lett. 2014;161:200-3.
  • 22. Buskila D, Sarzi-Puttini P, Ablin JN. The genetics of fibromyalgia syndrome. Pharmacogenomics. 2007;8(1):67–74.
  • 23. Zhang Z, Feng J, Mao A, Placa DL, Wu X, Longmate J, et al. SNPs in inflammatory genes CCL11 CCL4 and MEFV in a fibromyalgia family study. PLoS One. 2018;13(6):e0198625.
  • 24. Hall SK, Perregaux DG, Gabel CA, Woodworth T, Durham LK, Huizinga TW, et al. Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein. Arthritis Rheum. 2004;50:1976-83.

Year 2022, Volume 6, Issue 4, 428 - 431, 01.04.2022
https://doi.org/10.28982/josam.929820

Abstract

References

  • 1. Bellato E, Marini E, Castoldi F, Barbasetti N, Mattei L, Bonasia DE, et al. Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment. Pain Res Treat. 2012;2012:1-17.
  • 2. Ablin JN, Buskila D. Update on the genetics of the fibromyalgia syndrome. Best Pract Res Clin Rheumatol. 2015;29:20-8.
  • 3. Clauw DJ. Fibromyalgia: A clinical review. JAMA. 2014;311(15):1547-55.
  • 4. Knezevic NN, Tverdohleb T, Knezevic I, Candido KD. The role of genetic polymorphism in chronic pain patients. Int J Mol Sci. 2018;19(6):1707.
  • 5. Feng J, Zhang Z, Wu X, Mao A, Chang F, Deng X, et al. Discovery of potential new gene variants and inflammatory cytokine associations with fibromyalgia syndrome by whole exome sequencing. PLoS One. 2013;8(6):e65033.
  • 6. Mendieta D, De la Cruz-Aguilera DL, Barrera-Villalpando MI, Becerril-Villanueva E, Arreola R, Hernández-Ferreira E, et al. IL-8 and IL-6 primarily mediate the inflammatory response in fibromyalgia patients. J Neuroimmunol. 2016;290:22–5.
  • 7. Malhotra D, Saxena AK, Dar SA, Kumar V, Nasare N, Tripathi AK, et al. Evaluation of cytokine levels in fibromyalgia syndrome patients and its relationship to the severity of chronic pain. J Musculoskelet Pain. 2012;20:164–9.
  • 8. Bote ME, García JJ, Hinchado MD, Ortega E. Inflammatory/stress feedback dysregulation in women with fibromyalgia.Neuroimmunomodulation. 2012;19:343–51.
  • 9. Imamura M, Targino RA, Hsing WT, Imamura S, Azevedo RS, Boas LS, et al. Concentration of cytokines in patients with osteoarthritis of the knee and fibromyalgia. Clin Interv Aging. 2014;9:939–44.
  • 10. Ernberg E, Christidis B, Ghafouri B, Bileviciute-Ljungar I, Löfgren M, Bjersing J, et al. Plasma cytokine levels in fibromyalgia and their response to 15 weeks of progressive resistance exercise or relaxation therapy. Mediators of Inflamm. 2018;2018:3985154.
  • 11. Wallace DJ, Linker-Israeli M, Hallegua D, Silverman S, Silver D, Weisman MH. Cytokines play an aetiopathogenetic role in fibromyalgia: a hypothesis and pilot study. Rheumatology. 2001;40:743-9.
  • 12. Wang H, Moser M, Schiltenwolf M, Buchner M. Circulating cytokine levels compared to pain in patients with fibromyalgia-a prospective longitudinal study over 6 months. J Rheumatol. 2008;35:1366-70.
  • 13. Cetin B, Gulec H, Toktas HE, Ulutas O, Yilmaz SG, Isbir T. Objective measures of sleep in fibromyalgia syndrome: Relationship to clinical, psychiatric, and immunological variables. Psychiatry Research. 2018;263:125-9.
  • 14. Jewett KA, Krueger JM. Humoral sleep regulation; interleukin-1 and tumor necrosis factor. Vitam Horm. 2012;89:241-57.
  • 15. Lorton D, Lubahn CL, Estus C, Millar BA, Carter JL, Wood CA, et al. Bidirectional communication between the brain and the immune system: implications for physiological sleep and disorders with disrupted sleep. Neuroimmunomodulation. 2006;13:357-74.
  • 16. Menzies V, Lyon DE. Integrated review of the association of cytokines with fibromylgia and fibromyalgia core symptoms. Biological research for nursing. 2010;11(4):387-94.
  • 17. Salemi S, Rethage J, Wollina U, Michel BA, Gay RE, Gay S, Sprott H. Detection of interleukin 1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha in skin of patients with fibromyalgia. J Rheumatol. 2003;30(1):146-50.
  • 18. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Hauser W, Katz RL, et al. 2016 Revisions to the 2010/2011 fibromyalgia diagnostic criteria. Semin Arthritis Rheum. 2016;46(3):319-29.
  • 19. Sumpton JE, Moulin DE. Fibromyalgia. Handb Clin Neurol. 2014;119:513-27.
  • 20. Bazzichi L, Rossi A, Massimetti G, Giannaccini G, Guiliano T, De Feo F, et al. Cytokine patterns in fibromyalgia and their correlation with clinical manifestations. Clin Exp Rheumatol. 2007;25(2):225-30.
  • 21. Rodriguez-Pinto I, Agmon-Levin N, Howard A, Shoenfeld Y. Fibromyalgia and cytokines. Immunol Lett. 2014;161:200-3.
  • 22. Buskila D, Sarzi-Puttini P, Ablin JN. The genetics of fibromyalgia syndrome. Pharmacogenomics. 2007;8(1):67–74.
  • 23. Zhang Z, Feng J, Mao A, Placa DL, Wu X, Longmate J, et al. SNPs in inflammatory genes CCL11 CCL4 and MEFV in a fibromyalgia family study. PLoS One. 2018;13(6):e0198625.
  • 24. Hall SK, Perregaux DG, Gabel CA, Woodworth T, Durham LK, Huizinga TW, et al. Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein. Arthritis Rheum. 2004;50:1976-83.

Details

Primary Language English
Subjects Biochemistry and Molecular Biology, Psychiatry
Journal Section Research article
Authors

Buğra ÇETİN (Primary Author)
MALTEPE ÜNİVERSİTESİ TIP FAKÜLTESİ
0000-0002-7415-2926
Türkiye


Seda GÜLEÇ This is me
YEDITEPE UNIVERSITY, SCHOOL OF MEDICINE
0000-0002-8119-2862
Türkiye


Hüseyin GÜLEÇ
Erenköy Psychiatric and Neurological Diseases Training and Research Hospital
0000-0002-9227-9373
Türkiye


Özgür ULUTAŞ This is me
Erenköy Physical Therapy and Rehabilitation Hospital
0000-0002-5541-3369
Türkiye


Turgay İŞBİR
YEDITEPE UNIVERSITY, SCHOOL OF MEDICINE
0000-0002-7350-6032
Türkiye

Publication Date April 1, 2022
Published in Issue Year 2022, Volume 6, Issue 4

Cite

Bibtex @research article { josam929820, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2022}, volume = {6}, pages = {428 - 431}, doi = {10.28982/josam.929820}, title = {Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome}, key = {cite}, author = {Çetin, Buğra and Güleç, Seda and Güleç, Hüseyin and Ulutaş, Özgür and İşbir, Turgay} }
APA Çetin, B. , Güleç, S. , Güleç, H. , Ulutaş, Ö. & İşbir, T. (2022). Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome . Journal of Surgery and Medicine , 6 (4) , 428-431 . DOI: 10.28982/josam.929820
MLA Çetin, B. , Güleç, S. , Güleç, H. , Ulutaş, Ö. , İşbir, T. "Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome" . Journal of Surgery and Medicine 6 (2022 ): 428-431 <https://jsurgmed.com/en/pub/issue/69115/929820>
Chicago Çetin, B. , Güleç, S. , Güleç, H. , Ulutaş, Ö. , İşbir, T. "Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome". Journal of Surgery and Medicine 6 (2022 ): 428-431
RIS TY - JOUR T1 - Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome AU - Buğra Çetin , Seda Güleç , Hüseyin Güleç , Özgür Ulutaş , Turgay İşbir Y1 - 2022 PY - 2022 N1 - doi: 10.28982/josam.929820 DO - 10.28982/josam.929820 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 428 EP - 431 VL - 6 IS - 4 SN - -2602-2079 M3 - doi: 10.28982/josam.929820 UR - https://doi.org/10.28982/josam.929820 Y2 - 2022 ER -
EndNote %0 Journal of Surgery and Medicine Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome %A Buğra Çetin , Seda Güleç , Hüseyin Güleç , Özgür Ulutaş , Turgay İşbir %T Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome %D 2022 %J Journal of Surgery and Medicine %P -2602-2079 %V 6 %N 4 %R doi: 10.28982/josam.929820 %U 10.28982/josam.929820
ISNAD Çetin, Buğra , Güleç, Seda , Güleç, Hüseyin , Ulutaş, Özgür , İşbir, Turgay . "Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome". Journal of Surgery and Medicine 6 / 4 (April 2022): 428-431 . https://doi.org/10.28982/josam.929820
AMA Çetin B. , Güleç S. , Güleç H. , Ulutaş Ö. , İşbir T. Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome. J Surg Med. 2022; 6(4): 428-431.
Vancouver Çetin B. , Güleç S. , Güleç H. , Ulutaş Ö. , İşbir T. Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome. Journal of Surgery and Medicine. 2022; 6(4): 428-431.
IEEE B. Çetin , S. Güleç , H. Güleç , Ö. Ulutaş and T. İşbir , "Interleukin-1 beta gene polymorphisms in patients with fibromyalgia syndrome", Journal of Surgery and Medicine, vol. 6, no. 4, pp. 428-431, Apr. 2022, doi:10.28982/josam.929820

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