Case Report
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Year 2022, Volume 6, Issue 4, 535 - 536, 01.04.2022
https://doi.org/10.28982/josam.875764

Abstract

References

  • 1. Comi G, Freedman MS, Kappos L, Olsson TP, Miller AE, Wolinsky JS, et al. Pooled safety and tolerability data from four placebo-controlled teriflunomide studies and extensions. Mult Scler Relat Disord. 2016;5:97–104. doi: 10.1016/j. msard.2015.11.006.
  • 2. Oh J, O’Connor PW. An update of teriflunomide for treatment of multiple sclerosis. Ther Clin Risk Manag. 2013;9:177-90. doi: 10.2147/TCRM.S30947.
  • 3. Abdalla AE, Lambert N, Duan X, Xie J. Interleukin-10 Family and Tuberculosis: An Old Story Renewed. Int J Biol Sci. 2016;27;12(6):710-7. doi: 10.7150/ijbs.13881.
  • 4. Sirbu CA, Dantes E, Plesa CF, Axelerad AD, Ghinescu MC. Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review Medicina. 2020;56:1-7. doi: 10.3390/medicina560402025.
  • 5. Zhou X, Yang J, Zhang Z, Zhang L, Zhu B, Lie L, et al. Different Signaling Pathways Define Different Interferon-Stimulated Gene Expression during Mycobacteria Infection in Macrophages. Int. J. Mol. Sci. 2019;20:1-14. doi: 10.3390/ijms20030663.
  • 6. Köseoğlu M, Gözübatık-Çelik RG, Kürtüncü M. A case report with tuberculous meningitis during fingolimod treatment. 2020;46:102450. doi: 10.1016/j.msard.2020.102450.

A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy

Year 2022, Volume 6, Issue 4, 535 - 536, 01.04.2022
https://doi.org/10.28982/josam.875764

Abstract

A case of pulmonary tuberculosis (TB) in a patient with multiple sclerosis (MS) receiving teriflunomide is described. A 56-year-old woman with MS started interferon beta-1a treatment in 2009. Due to side effects, her physician switched her to glatiramer acetate. Over the last three years, she opted not to continue the glatiramer acetate. At the end of 2017, her symptoms reappeared, and her radiological and clinical examination showed disease progression. Teriflunomide (14 mg/day) treatment was started, and in the 15th month of teriflunomide use, a rash on the skin, coughing, night sweating fits, weakness and back pain developed. She was diagnosed with pulmonary TB based on pulmonary examination. Her purified protein derivative (PPD) score was 22. Anti-TB therapy was initiated immediately. At last visit in January 2020, TB was discovered. Her blood tests were within normal limits. Her expanded disability status score (EDSS) score was 2.5. Subcutaneous glatiramer acetate was re-initiated. A rare case of pulmonary TB under teriflunomide use is described in this case. Teriflunomide therapy should be considered in cases in which latent TB may be re-activated.

References

  • 1. Comi G, Freedman MS, Kappos L, Olsson TP, Miller AE, Wolinsky JS, et al. Pooled safety and tolerability data from four placebo-controlled teriflunomide studies and extensions. Mult Scler Relat Disord. 2016;5:97–104. doi: 10.1016/j. msard.2015.11.006.
  • 2. Oh J, O’Connor PW. An update of teriflunomide for treatment of multiple sclerosis. Ther Clin Risk Manag. 2013;9:177-90. doi: 10.2147/TCRM.S30947.
  • 3. Abdalla AE, Lambert N, Duan X, Xie J. Interleukin-10 Family and Tuberculosis: An Old Story Renewed. Int J Biol Sci. 2016;27;12(6):710-7. doi: 10.7150/ijbs.13881.
  • 4. Sirbu CA, Dantes E, Plesa CF, Axelerad AD, Ghinescu MC. Active Pulmonary Tuberculosis Triggered by Interferon Beta-1b Therapy of Multiple Sclerosis: Four Case Reports and a Literature Review Medicina. 2020;56:1-7. doi: 10.3390/medicina560402025.
  • 5. Zhou X, Yang J, Zhang Z, Zhang L, Zhu B, Lie L, et al. Different Signaling Pathways Define Different Interferon-Stimulated Gene Expression during Mycobacteria Infection in Macrophages. Int. J. Mol. Sci. 2019;20:1-14. doi: 10.3390/ijms20030663.
  • 6. Köseoğlu M, Gözübatık-Çelik RG, Kürtüncü M. A case report with tuberculous meningitis during fingolimod treatment. 2020;46:102450. doi: 10.1016/j.msard.2020.102450.

Details

Primary Language English
Subjects Clinical Neurology
Journal Section Case report
Authors

Rabia Gökçen GÖZÜBATIK ÇELİK (Primary Author)
İSTANBUL BAKIRKÖY PROF. DR. MAZHAR OSMAN APPLICATION AND RESEARCH CENTER FOR PSYCHIATRIC AND NERVE DISEASES
0000-0002-8186-8703
Türkiye


Musa ÖZTÜRK
İSTANBUL BAKIRKÖY PROF. DR. MAZHAR OSMAN APPLICATION AND RESEARCH CENTER FOR PSYCHIATRIC AND NERVE DISEASES
0000-0001-9652-384X
Türkiye

Publication Date April 1, 2022
Published in Issue Year 2022, Volume 6, Issue 4

Cite

Bibtex @case report { josam875764, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2022}, volume = {6}, pages = {535 - 536}, doi = {10.28982/josam.875764}, title = {A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy}, key = {cite}, author = {Gözübatık Çelik, Rabia Gökçen and Öztürk, Musa} }
APA Gözübatık Çelik, R. G. & Öztürk, M. (2022). A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy . Journal of Surgery and Medicine , 6 (4) , 535-536 . DOI: 10.28982/josam.875764
MLA Gözübatık Çelik, R. G. , Öztürk, M. "A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy" . Journal of Surgery and Medicine 6 (2022 ): 535-536 <https://jsurgmed.com/en/pub/issue/69115/875764>
Chicago Gözübatık Çelik, R. G. , Öztürk, M. "A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy". Journal of Surgery and Medicine 6 (2022 ): 535-536
RIS TY - JOUR T1 - A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy AU - Rabia Gökçen Gözübatık Çelik , Musa Öztürk Y1 - 2022 PY - 2022 N1 - doi: 10.28982/josam.875764 DO - 10.28982/josam.875764 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 535 EP - 536 VL - 6 IS - 4 SN - -2602-2079 M3 - doi: 10.28982/josam.875764 UR - https://doi.org/10.28982/josam.875764 Y2 - 2022 ER -
EndNote %0 Journal of Surgery and Medicine A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy %A Rabia Gökçen Gözübatık Çelik , Musa Öztürk %T A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy %D 2022 %J Journal of Surgery and Medicine %P -2602-2079 %V 6 %N 4 %R doi: 10.28982/josam.875764 %U 10.28982/josam.875764
ISNAD Gözübatık Çelik, Rabia Gökçen , Öztürk, Musa . "A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy". Journal of Surgery and Medicine 6 / 4 (April 2022): 535-536 . https://doi.org/10.28982/josam.875764
AMA Gözübatık Çelik R. G. , Öztürk M. A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy. J Surg Med. 2022; 6(4): 535-536.
Vancouver Gözübatık Çelik R. G. , Öztürk M. A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy. Journal of Surgery and Medicine. 2022; 6(4): 535-536.
IEEE R. G. Gözübatık Çelik and M. Öztürk , "A case of multiple sclerosis diagnosed with tuberculosis during teriflunomide therapy", Journal of Surgery and Medicine, vol. 6, no. 4, pp. 535-536, Apr. 2022, doi:10.28982/josam.875764

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