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A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study

Year 2019, Volume 3, Issue 5, 357 - 360, 28.05.2019
https://doi.org/10.28982/josam.558971

Abstract

Aim: In recent years, alternative therapies targeting directly cancer cells and targeted agents have been developed. The aim of this study is to develop a new perspective on alternative therapies on local targets, as identify the correlation between positron emission tomography-computed tomography (PET-CT) SUVmax and histological type of the tumor in non-small cell lung cancers. 

Methods: This study is based on the retrospective examination of patients who underwent PET-CT for preoperative staging with non-small cell lung cancer between January 2012 and May 2015. Statistical analyses are made between SUVmax values and histopathological types.

Results: The study is including 448 patients who underwent surgery for non-small cell lung cancer. The average size of the mass was 4.5 cm and the average SUVmax value was calculated as 13.3. The patients were classified into five groups according to their histopathological diagnosis. PET-CT fluorodeoxyglucose (FDG) involvement has been classified for different histopathological types. Statistically significant correlation was identified between the tumor size and histopathological diagnosis. It was found that the difference between SUVmax values of the adenocarcinoma tumors and other types are found statistically significant. SUVmax values have been found mostly between 5-10 in patients with adenocarcinoma and 10-15 in others.

Conclusion: Considering that there are statistically significant differences between PET-CT SUVmax values of tumor cell types, we argue that radiopharmaceuticals which could provide different and local treatment should be used in cancer treatment, they should be combined with alternative therapies such as loco-regional treatment methods, and the studies in that direction should continue in line with the technological developments.

References

  • 1. Shields TW. Carcinoma of the lung. Shields TW; General Thoracic Surgery. Lippincott, Williams and Wilkins.2000 fifth edition. P1215-1442.
  • 2. Pearson FG. Lung Cancer. Pearson FG; Thoracic Surgery. Churchill Livingstone. 2002 second edition. P 772-924.
  • 3. Jemal A, Thomas A, Murray T, Thun. Cancer statistics 2002. CA Cancer J Clin. 2002;52(1):23-47.
  • 4. Hendriks JM, Van Putte BP, Grootenboers M, Van Boven WJ, Schramel F, Van Schil PE. Isolated lung perfusion for pulmonary metastases. Thorac Surg Clin. 2006;16(2):185-98.
  • 5. Ranney DF. Drug targeting to the lungs. Biochem Pharmacol. 1986;35(7):1063-9.
  • 6. Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, et al. Staging of non-small cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med. 2003;348(25):2500-7.
  • 7. Meller J, Sahlmann CO, Scheel AK. 18F-FDG PET and PET/CT in fever of unknown origin. J Nucl Med. 2007;48(1):3545.
  • 8. Arslan N. Onkolojik PET çalışmaları. PET El Kitabı. 2008;12-18.
  • 9. Den Hengst WA,Van Putte BP, Hendriks JM, Stockman B, Van Boven WJ, Weyler J, et al. Long-term survival of a phase I clinical trial of isolated lung perfusion with melphalan for resectable lung metastases. Eur J Cardiothorac Surg. 2010;38(5):621-7.
  • 10. Brown RS, Leung JY, Kison PV, Zasadny KR, Flint A, Wahl RL. Glucose transporters and FDG uptake in untreated primary human non-small cell lung cancer. J Nucl Med. 1999;40(4):556-65.
  • 11. Aquino SL, Halpern EF, Kuester LB, Fischman AJ. FDG-PET and CT features of non-small cell lung cancer based on tumor type. Int J Mol Med. 2007;19(3):495- 9.
  • 12. Eschmann SM, Friedel G, Paulsen F, Reimold M, Hehr T, Budach W et al. Is standardised (18)F-FDG uptake value an outcome predictor in patients with stage III non-small cell lung cancer? Eur J Nucl Med Mol Imaging. 2006;33(3):263-9.
  • 13. Yalcınkaya E, Anar C, Yavuz YM, Unsal I, Guldaval F, Kocakuşak D, et al. Prognostic Importance of SUVmax Value in PET/CT and Correlation SUVmax Value Between Lymph Node, Distant Metastasis in Non-Small Cell Lung Cancer. Izmir Gogus Hastanesi Dergisi. 2015;24(3):127-37.

Küçük hücreli dışı akciğer kanserinde histopatolojik tip ile PET-BT SUVmax arasındaki korelasyon üzerine farklı bir bakış açısı, Retrospektif kohort çalışma

Year 2019, Volume 3, Issue 5, 357 - 360, 28.05.2019
https://doi.org/10.28982/josam.558971

Abstract

Amaç: Son yıllarda akciğer kanserinin moleküler biyolojisi konusunda yapılan araştırmalar ile kanser hücreleri yanında normal hücreleri de hedef alan sistemik konvansiyonel tedavi yöntemlerinin yanında direk kanser hücrelerini hedef alan tedaviler gelişmiş ve böylece lokal hedefe yönelik ajanlar başlığı altında yeni tedavi alternatifleri üzerine yoğunlaşılmıştır. Bizim çalışmamızda ise amaç lokal hedefe yönelik tedavi alternatifleri konusunda farklı bir kapı aralamak, küçük hücreli dışı akciğer kanserlerinde kitle Pozitron emisyon tomografi-bilgisayarlı tomografi (PET-BT) SUVmax değerinin tümör histolojik tipi ile korelasyon gösterip göstermediğini belirlemektir.

Yöntemler: Çalışmamız, ocak 2012 ile mayıs 2015 yılları arasında preoperatif evreleme amaçlı istenen PET-BT ve sonrasında opere edilen küçük hücreli dışı akciğer kanseri olgularının retrospektif incelenmesi ile oluşturuldu. PET-BT’deki kitlenin SUVmax değeri ve histopatolojik tip kaydedilerek istatistiksel değerlendirme yapıldı.

Bulgular: Çalışmaya KHDAK nedeni ile opere edilen 448 olgu dahil edildi. Olguların ortalama kitle boyutları 4,5cm, ortalama SUVmax değerleri 13,3 olarak hesaplanmıştır. Olgular histopatolojik tanılarına göre 5 grupta toplandı. PET-BT fluorodeoksiglikoz (FDG) tutulum SUVmax değerleri gruplandırıldı ve farklı histopatolojik türde malignitelerin ağırlıklı olarak gösterdikleri tutulum değerleri belirlenmeye çalışıldı. Tümör boyutu ve histopatolojik tanılar ile SUVmax değerleri arasında anlamlı ilişki tespit edildi. Adenokarsinom hücre türüne ait tümörlerin diğer karsinomlara göre PET-BT SUVmax değerlerinin anlamlı düzeyde farklılık gösterdiği tespit edildi. SUVmax değerlerinin ağırlıklı olarak adenokarsinom olgularında 5-10 arası düzeylerde, diğer türlerde genellikle 10-15 arası tutulum gösterdiği belirlendi.

Sonuç: Tümör hücre tiplerinin PET-BT SUVmax değerleri anlamlı düzeyde farklılık gösterdiklerinden yola çıkılarak PET’te farklı ve lokal tedaviyi sağlayacak radyofarmasötiklerin kullanılması ve değişik alternatifler oluşturulması konusunda teknolojik gelişmeler baz alınarak çalışmalar devam etmelidir.

References

  • 1. Shields TW. Carcinoma of the lung. Shields TW; General Thoracic Surgery. Lippincott, Williams and Wilkins.2000 fifth edition. P1215-1442.
  • 2. Pearson FG. Lung Cancer. Pearson FG; Thoracic Surgery. Churchill Livingstone. 2002 second edition. P 772-924.
  • 3. Jemal A, Thomas A, Murray T, Thun. Cancer statistics 2002. CA Cancer J Clin. 2002;52(1):23-47.
  • 4. Hendriks JM, Van Putte BP, Grootenboers M, Van Boven WJ, Schramel F, Van Schil PE. Isolated lung perfusion for pulmonary metastases. Thorac Surg Clin. 2006;16(2):185-98.
  • 5. Ranney DF. Drug targeting to the lungs. Biochem Pharmacol. 1986;35(7):1063-9.
  • 6. Lardinois D, Weder W, Hany TF, Kamel EM, Korom S, Seifert B, et al. Staging of non-small cell lung cancer with integrated positron-emission tomography and computed tomography. N Engl J Med. 2003;348(25):2500-7.
  • 7. Meller J, Sahlmann CO, Scheel AK. 18F-FDG PET and PET/CT in fever of unknown origin. J Nucl Med. 2007;48(1):3545.
  • 8. Arslan N. Onkolojik PET çalışmaları. PET El Kitabı. 2008;12-18.
  • 9. Den Hengst WA,Van Putte BP, Hendriks JM, Stockman B, Van Boven WJ, Weyler J, et al. Long-term survival of a phase I clinical trial of isolated lung perfusion with melphalan for resectable lung metastases. Eur J Cardiothorac Surg. 2010;38(5):621-7.
  • 10. Brown RS, Leung JY, Kison PV, Zasadny KR, Flint A, Wahl RL. Glucose transporters and FDG uptake in untreated primary human non-small cell lung cancer. J Nucl Med. 1999;40(4):556-65.
  • 11. Aquino SL, Halpern EF, Kuester LB, Fischman AJ. FDG-PET and CT features of non-small cell lung cancer based on tumor type. Int J Mol Med. 2007;19(3):495- 9.
  • 12. Eschmann SM, Friedel G, Paulsen F, Reimold M, Hehr T, Budach W et al. Is standardised (18)F-FDG uptake value an outcome predictor in patients with stage III non-small cell lung cancer? Eur J Nucl Med Mol Imaging. 2006;33(3):263-9.
  • 13. Yalcınkaya E, Anar C, Yavuz YM, Unsal I, Guldaval F, Kocakuşak D, et al. Prognostic Importance of SUVmax Value in PET/CT and Correlation SUVmax Value Between Lymph Node, Distant Metastasis in Non-Small Cell Lung Cancer. Izmir Gogus Hastanesi Dergisi. 2015;24(3):127-37.

Details

Primary Language English
Subjects Surgery
Journal Section Research article
Authors

Özgur Ömer YILDIZ (Primary Author)
Yildirim Beyazit University, Faculty of Medicine, Department of Thoracic Surgery, Ankara, Turkey
0000-0001-7314-3131
Türkiye


İlknur AYTEKİN ÇELİK
Yildirim Beyazit University, Faculty of Medicine, Department of Thoracic Surgery, Ankara, Turkey
0000-0003-0754-680X
Türkiye

Publication Date May 28, 2019
Published in Issue Year 2019, Volume 3, Issue 5

Cite

Bibtex @research article { josam558971, journal = {Journal of Surgery and Medicine}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2019}, volume = {3}, number = {5}, pages = {357 - 360}, doi = {10.28982/josam.558971}, title = {A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study}, key = {cite}, author = {Yıldız, Özgur Ömer and Aytekin Çelik, İlknur} }
APA Yıldız, Ö. Ö. & Aytekin Çelik, İ. (2019). A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study . Journal of Surgery and Medicine , 3 (5) , 357-360 . DOI: 10.28982/josam.558971
MLA Yıldız, Ö. Ö. , Aytekin Çelik, İ. "A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study" . Journal of Surgery and Medicine 3 (2019 ): 357-360 <https://jsurgmed.com/en/pub/issue/44971/558971>
Chicago Yıldız, Ö. Ö. , Aytekin Çelik, İ. "A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study". Journal of Surgery and Medicine 3 (2019 ): 357-360
RIS TY - JOUR T1 - A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study AU - Özgur Ömer Yıldız , İlknur Aytekin Çelik Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.558971 DO - 10.28982/josam.558971 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 357 EP - 360 VL - 3 IS - 5 SN - -2602-2079 M3 - doi: 10.28982/josam.558971 UR - https://doi.org/10.28982/josam.558971 Y2 - 2019 ER -
EndNote %0 Journal of Surgery and Medicine A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study %A Özgur Ömer Yıldız , İlknur Aytekin Çelik %T A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 5 %R doi: 10.28982/josam.558971 %U 10.28982/josam.558971
ISNAD Yıldız, Özgur Ömer , Aytekin Çelik, İlknur . "A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study". Journal of Surgery and Medicine 3 / 5 (May 2019): 357-360 . https://doi.org/10.28982/josam.558971
AMA Yıldız Ö. Ö. , Aytekin Çelik İ. A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study. J Surg Med. 2019; 3(5): 357-360.
Vancouver Yıldız Ö. Ö. , Aytekin Çelik İ. A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study. Journal of Surgery and Medicine. 2019; 3(5): 357-360.
IEEE Ö. Ö. Yıldız and İ. Aytekin Çelik , "A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study", Journal of Surgery and Medicine, vol. 3, no. 5, pp. 357-360, May. 2019, doi:10.28982/josam.558971

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