Research Article
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Beyaz küre alt tipleri oranının supraventriküler taşikardili hastalarda değerlendirilmesi: Retrospektif kohort çalışma

Year 2019, Volume 3, Issue 4, 297 - 299, 28.04.2019
https://doi.org/10.28982/josam.510973

Abstract

Amaç: Nötrofil/lenfosit oranı (NLO), monosit/lenfosit oranı (MLO) ve lenfosif/monosit oranı (LMO) yeni kardiyovasküler risk belirleyicileri olarak değerlendirilmiştir. Inflammation has been demonstrated to be associated with various types of arrhythmia. Bu çalışmadaki amacımız geriye dönük olarak supraventriküler taşikardi (SVT) tanılı hastalarda NLO, LMO ve MLO ile ilişkisini araştırmayı amaçladık.

Yöntemler: Çalışmamız 18 yaş ve üzerinde, Aralık 2017- Aralık 2018 tarihleri arasında kliniğimizde takip edilen 59 hastayı içermektedir. Hastaların 33 tanesi çarpıntı tanısı konmuş ablasyon için yatış verdiğimiz hastalar olup, diğer 26 tanesi noninvaziv yöntemlerle ritm bozukluğu tanısı konulamayan fakat çarpıntı şikayetleri devam eden kesin tanısını koyabilmek için elektrofizyolojik çalışma (EPS) yaptığımız hastalardan oluşmaktadır. Tüm hastalardan işlem öncesi hemogram ölçümü için kan örneği alındı. NLO değeri nötrofil sayısının lenfosit sayısına oranı, MLO değeri monosit sayısının lenfosit sayısına oranı ve LMO değeri lenfosit sayısının monosit sayısına oranı olarak hesaplandı. Ayrıca SVT tanısı mevcut hastalarımıza tedavi amaçlı; hem de noninvaziv yöntemlerle tanısı konulamayan çarpıntı hastalarına tanı ve tedavi amaçlı EPS yapıldı. 

Bulgular: Çalışmaya SVT'li 33 hasta ve EPS sonucu normal olan 26 tane sağlıklı kontrol grubu dahil edildi. Hematolojik parametreler karşılaştırıldığında NLO (1,96 (0,69) 103/μL karşı 2,17 (1,28) 103/μL, p=0,42) istatiksel olarak anlamlı değildi. Bir diğer parametrelerde hem MLO iki grup arasında (0,25 (0,09) 103/μL karşı 0,22 (0,08) 103/μL, p=0,19) hem de LMO iki grup arasında istatiksel olarak anlamlı değildi. (4,38 (1,37) 103/μL karşı 4,64 (1,45) 103/μL, p=0,49).

Sonuç: Yaptığımız çalışmada NLO, LMO ve MLO değerlerinin SVT’nin varlığı için kullanılabilir gösterge olmadıklarını göstermiş olduk.

References

  • 1. Tamhane UU, Aneja S, Montgomery D, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008;102:653-7.
  • 2. Uthamalingam S, Patvardhan EA, Subramanian S, Ahmed W, Martin W, Daley M, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol. 2011;107:433-8.
  • 3. Huang G, Zhong XN, Zhong B, Chen YQ, Liu ZZ, Su L, et al. Significance of white blood cell count and its subtypes in patients with acute coronary syndrome. Eur J Clin Invest. 2009;39:348-58.
  • 4. Horne BD, Anderson JL, John JM, Weaver A, Bair TL, Jensen KR, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol. 2005;45:1638-43.
  • 5. Ross R. Atherosclerosis –an inflmamatory disease. N Engl J Med. 1999;340:115-26.
  • 6. Klein RM, Vester EG, Brehm MU, Dees H, Picard F, Niederacher D, et al. Inflammation of the myocardium as an arrhythmia trigger. Z Kardiol. 2000;89 Suppl 3:24-35.
  • 7. Chimienti M, Barbieri S. Treatment of supraventricular tachyarrhythmias: drugs or ablation? G Ital Cardiol. 1996;26(2):213-26.
  • 8. Horne BD, Anderson JL, John JM, Weasver A, Bair TL, Jensen Kr, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol. 2005;45:1638-43.
  • 9. Balta I, Balta S, Demirkol S, Celik T, Ekiz O, Cakar M, et al. Aortic arterial stiffness is a moderate predictor of cardiovascular disease in patients with psoriasis vulgaris. Angiology. 2014 Jan;65(1):74-8. doi: 10.1177/0003319713485805.
  • 10. Balta S, Celik T, Mikhailidis DP, Ozturk C, Demirkol S, Aparci M, et al. The Relation Between Atherosclerosis and the Neutrophil-Lymphocyte Ratio. Clin Appl Thromb Hemost. 2016 Jul;22(5):405-11. doi: 10.1177/1076029615569568.
  • 11. Frustaci A, Chimenti C, Bellocci F, Morgante E, Russo MA, Maseri A. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation. 1997;96:1180-4.
  • 12. Chung MK, Martin DO, Sprecher D, Wazni O, Kanderian A, Carnes CA, et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation. 2001;104:2886-91.
  • 13. Osmancik P, Peroutka Z, Budera P, Herman D, Stros P, Straka Z, et al. Decreased Apoptosis following Successful Ablation of Atrial Fibrillation. European Cytokine Network. 2010;4:278-84.
  • 14. Ocak T, Erdem A, Duran A, Tekelioglu U, Öztürk S, Ayhan S, et al. The importance of the mean platelet volume in the diagnosis of supraventricular tachycardia. Afr Health Sci. 2013;13(3):590-4.
  • 15. Aydın M, Yıldız A, Yüksel M, Polat N, Aktan A, İslamoğlu Y. Assessment of the neutrophil/lymphocyte ratio in patients with supraventricular tachycardia. Anatol J Cardiol. 2016;16(1):29-33.
  • 16. Chen Y, Zhang Y, Zhao G, Chen C, Yang P, Ye S, Tan X. Difference in Leukocyte Composition between Women before and after Menopausal Age, and Distinct Sexual Dimorphism. PLoS One. 2016;11(9):e0162953.
  • 17. Lee JS, Kim NY, Na SH, Youn YH, Shin CS. Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea. Medicine (Baltimore). 2018;97(26):e11138.

Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study

Year 2019, Volume 3, Issue 4, 297 - 299, 28.04.2019
https://doi.org/10.28982/josam.510973

Abstract

Aim: Neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR) and lymphocyte/monocyte ratio (LMR) have been considered to be the new cardiovascular risk predictors. Inflammation has been shown to be associated with various types of arrhythmia. This study aimed to investigate the relationship between NLR, LMR and MLR in patients with supraventricular tachycardia (SVT).

Methods: Our study included 59 patients aged 18 years or older who visited our clinic between December 2017 and December 2018. Thirty-three patients were diagnosed with definitive diagnosis of tachycardia using electrocardiographic (ECG) method, and hospitalized for ablation. The other 26 patients were the ones who underwent electrophysiological study (EPS) as it was not possible to make a diagnosis of arrhythmia using non-invasive methods despite ongoing complaints of palpitation. Blood samples were taken from all patients for pre-operative complete blood count analysis. NLR was calculated as the ratio of neutrophil count to lymphocyte count. MLR was calculated as the ratio of monocyte count to lymphocyte count. LMR was calculated as the ratio of lymphocyte count to monocyte count. In addition, electrophysiological study (EPS) was performed for treatment purposes in patients diagnosed with SVT; and for diagnosis and treatment purposes in patients who have the complaint of palpitation, however, could not be diagnosed using non-invasive methods.

Results: This study included 33 patients with SVT and 26 healthy controls who underwent EPS. When hematological parameters were compared, there was no statistically significant difference in NLR values (1.96 (0.69) 103/μL vs. 2.17 (1.29) 103/μL, p=0.42). Moreover, both MLR (0.25 (0.09) 103/μL vs. 0.22 (0.08)) 103/μL, p=0.19) and LMR (4.64 (1.37) 103/μL vs. 4.64 (1.45)) 103/μL, p = 0.49) were not statistically significant between the two groups.

Conclusion: This study showed that NLR, LMR and MLR values cannot be used as predictors for the presence of SVT.

References

  • 1. Tamhane UU, Aneja S, Montgomery D, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008;102:653-7.
  • 2. Uthamalingam S, Patvardhan EA, Subramanian S, Ahmed W, Martin W, Daley M, et al. Utility of the neutrophil to lymphocyte ratio in predicting long-term outcomes in acute decompensated heart failure. Am J Cardiol. 2011;107:433-8.
  • 3. Huang G, Zhong XN, Zhong B, Chen YQ, Liu ZZ, Su L, et al. Significance of white blood cell count and its subtypes in patients with acute coronary syndrome. Eur J Clin Invest. 2009;39:348-58.
  • 4. Horne BD, Anderson JL, John JM, Weaver A, Bair TL, Jensen KR, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol. 2005;45:1638-43.
  • 5. Ross R. Atherosclerosis –an inflmamatory disease. N Engl J Med. 1999;340:115-26.
  • 6. Klein RM, Vester EG, Brehm MU, Dees H, Picard F, Niederacher D, et al. Inflammation of the myocardium as an arrhythmia trigger. Z Kardiol. 2000;89 Suppl 3:24-35.
  • 7. Chimienti M, Barbieri S. Treatment of supraventricular tachyarrhythmias: drugs or ablation? G Ital Cardiol. 1996;26(2):213-26.
  • 8. Horne BD, Anderson JL, John JM, Weasver A, Bair TL, Jensen Kr, et al. Which white blood cell subtypes predict increased cardiovascular risk? J Am Coll Cardiol. 2005;45:1638-43.
  • 9. Balta I, Balta S, Demirkol S, Celik T, Ekiz O, Cakar M, et al. Aortic arterial stiffness is a moderate predictor of cardiovascular disease in patients with psoriasis vulgaris. Angiology. 2014 Jan;65(1):74-8. doi: 10.1177/0003319713485805.
  • 10. Balta S, Celik T, Mikhailidis DP, Ozturk C, Demirkol S, Aparci M, et al. The Relation Between Atherosclerosis and the Neutrophil-Lymphocyte Ratio. Clin Appl Thromb Hemost. 2016 Jul;22(5):405-11. doi: 10.1177/1076029615569568.
  • 11. Frustaci A, Chimenti C, Bellocci F, Morgante E, Russo MA, Maseri A. Histological substrate of atrial biopsies in patients with lone atrial fibrillation. Circulation. 1997;96:1180-4.
  • 12. Chung MK, Martin DO, Sprecher D, Wazni O, Kanderian A, Carnes CA, et al. C-reactive protein elevation in patients with atrial arrhythmias: inflammatory mechanisms and persistence of atrial fibrillation. Circulation. 2001;104:2886-91.
  • 13. Osmancik P, Peroutka Z, Budera P, Herman D, Stros P, Straka Z, et al. Decreased Apoptosis following Successful Ablation of Atrial Fibrillation. European Cytokine Network. 2010;4:278-84.
  • 14. Ocak T, Erdem A, Duran A, Tekelioglu U, Öztürk S, Ayhan S, et al. The importance of the mean platelet volume in the diagnosis of supraventricular tachycardia. Afr Health Sci. 2013;13(3):590-4.
  • 15. Aydın M, Yıldız A, Yüksel M, Polat N, Aktan A, İslamoğlu Y. Assessment of the neutrophil/lymphocyte ratio in patients with supraventricular tachycardia. Anatol J Cardiol. 2016;16(1):29-33.
  • 16. Chen Y, Zhang Y, Zhao G, Chen C, Yang P, Ye S, Tan X. Difference in Leukocyte Composition between Women before and after Menopausal Age, and Distinct Sexual Dimorphism. PLoS One. 2016;11(9):e0162953.
  • 17. Lee JS, Kim NY, Na SH, Youn YH, Shin CS. Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea. Medicine (Baltimore). 2018;97(26):e11138.

Details

Primary Language English
Subjects General and Internal Medicine
Journal Section Research article
Authors

Uğur KÜÇÜK (Primary Author)
SİVAS NUMUNE HASTANESİ
0000-0003-4669-7387
Türkiye


Mehmet ARSLAN This is me
CANAKKALE ONSEKIZ MART UNIVERSITY, FACULTY OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, DEPARTMENT OF CARDIOLOGY
0000-0001-8785-7944
Türkiye

Publication Date April 28, 2019
Published in Issue Year 2019, Volume 3, Issue 4

Cite

Bibtex @research article { josam510973, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2019}, volume = {3}, pages = {297 - 299}, doi = {10.28982/josam.510973}, title = {Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study}, key = {cite}, author = {Küçük, Uğur and Arslan, Mehmet} }
APA Küçük, U. & Arslan, M. (2019). Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study . Journal of Surgery and Medicine , 3 (4) , 297-299 . DOI: 10.28982/josam.510973
MLA Küçük, U. , Arslan, M. "Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study" . Journal of Surgery and Medicine 3 (2019 ): 297-299 <https://jsurgmed.com/en/pub/issue/44120/510973>
Chicago Küçük, U. , Arslan, M. "Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study". Journal of Surgery and Medicine 3 (2019 ): 297-299
RIS TY - JOUR T1 - Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study AU - Uğur Küçük , Mehmet Arslan Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.510973 DO - 10.28982/josam.510973 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 297 EP - 299 VL - 3 IS - 4 SN - -2602-2079 M3 - doi: 10.28982/josam.510973 UR - https://doi.org/10.28982/josam.510973 Y2 - 2019 ER -
EndNote %0 Journal of Surgery and Medicine Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study %A Uğur Küçük , Mehmet Arslan %T Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 4 %R doi: 10.28982/josam.510973 %U 10.28982/josam.510973
ISNAD Küçük, Uğur , Arslan, Mehmet . "Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study". Journal of Surgery and Medicine 3 / 4 (April 2019): 297-299 . https://doi.org/10.28982/josam.510973
AMA Küçük U. , Arslan M. Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study. J Surg Med. 2019; 3(4): 297-299.
Vancouver Küçük U. , Arslan M. Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study. Journal of Surgery and Medicine. 2019; 3(4): 297-299.
IEEE U. Küçük and M. Arslan , "Assessment of the white blood cell subtypes ratio in patients with supraventricular tachycardia: Retrospective cohort study", Journal of Surgery and Medicine, vol. 3, no. 4, pp. 297-299, Apr. 2019, doi:10.28982/josam.510973

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