Year 2018, Volume 2 , Issue 3, Pages 324 - 329 2018-09-01

Akciğer tümörlerinde CyberKnife® ile stereotaktik ablatif radyoterapi sonuçlarımız: Tek merkez deneyimi
Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience

Ebru ATASEVER AKKAŞ [1] , Ebru KARAKAYA [2] , Gonca ALTINIŞIK İNAN [3] , Yasemin GÜZLE ADAŞ [4] , Ömer YAZICI [5] , Esra KEKİLLİ [6] , Ferhat KIRAN [7] , Ferihan ERTAN [8] , Bülent KÜÇÜKPİLAKÇI [9] , Yıldız GÜNEY [10]


Amaç: Primer ve oligometastatik akciğer karsinomu tanısıyla CyberKnife® (Accuray, Sunnyvale, CA, USA) kullanarak stereotaktik ablatif radyoterapi (SABR) ile tedavi edilen olgularımızın tedavi sonuçlarımızı değerlendirmek.

Yöntemler: Bu tanımlayıcı çalışmaya Mart 2011- Temmuz 2015 tarihleri arasında robotik lineer akselatör ile SABR tedavisi alan primer akciğer kanserli (n=21) ve oligometastatik akciğer tümörlü (n=9) 30 hastanın 29’u dahil edilmiştir. 30 tümörden 21'i KHDAK, 9'u metastatik akciğer hastalığı idi. Tüm tedavi adımları aynı doktor tarafından kontrol edildi. Tedavi, Synchrony (21 hasta), Synchrony ile Xsight akciğer (4 hasta) ve Xsight vertebra (5 hasta) ile fidusiyal izleme dahil olmak üzere farklı izleme yöntemleri kullanılarak verildi. Tedavi, lokal ve diğer tümörle ilişkili faktörlere bağlı olarak, haftada iki veya üç farklı fraksiyonlarda verildi. Lokal kontrol ve genel sağkalım üzerinde potansiyel olarak etkili faktörler araştırıldı.

Bulgular: Lokal kontrol için medyan takip süresi 11 ay (2,4-39 ay) idi. Bilinen takip verileri bulunan 25 hastanın 1, 2 ve 3 yıllık lokal kontrol (LC) oranları sırasıyla% 82,8, % 82,8 ve % 55,2 idi. Tüm sağkalım oranları primer akciğer tümörlü hastalar için 1,2 ve 3 yıllık sırasıyla %72,2, %64,2 ve %51,4 ve metastatik akciğer tümörleri için 1 yıllık %71 idi. Cinsiyet haricinde, tek değişkenli analizde faktörlerin hiçbiri lokal kontrol ile istatistiksel olarak anlamlı bir şekilde ilişkili değildi; kadın cinsiyeti daha kötü lokal kontrol ile ilişkiliydi (p=0.001). Ayrıca genel sağkalımın tek değişkenli analizinde, kadınlarda da daha kötü bir sağkalım eğilimi vardı (p=0.07).

Sonuç: Bu küçük çalışma, CyberKnife® için daha az toksisite ile farklı tedavi takip yöntemlerinin kullanımı hakkında biraz fikir verebilir.

Aim: To evaluate retrospectively clinical outcomes of treated with stereotactic ablative radiotherapy (SABR) using the CyberKnife® (Accuray, Sunnyvale, CA, USA), for early primary and oligometastatic lung tumors.

Methods: This descriptive study included thirty tumors from 29 patients with primary lung cancer (n=21) or oligometastatic lung tumors (n=9), who underwent SABR with robotic linear accelerator between March 2011 and July2015. Out of the 30 tumors, 21 were NSCLC, 9 were metastatic lung disease. Treatment was given using different tracking methods including fiducial tracking with Synchrony (21 patients) , Xsight lung with Synchrony (4 patients) and Xsight spine (5 patients). Treatment was delivered two to three fractions per week and with different fractionations depending on location and other tumor related factors. Factors, potentially effective on local control and overall survival were investigated.

Results: Median follow-up time for local control was 11 months (2.4-39 months). Of 25 patients with known follow-up data, local control (LC) rates for 1, 2 and 3 years were 82.8%, 82.8% and 55.2 %, respectively. Overall survival (OS) rates for primary lung tumor patients 1, 2 and 3 years were 72.2%, 64.2%, 51.4% and metastatic lung tumor patients for 1 year was 71%, respectively. Except for gender, none of the factors were statistically significantly associated with local control in univariate analysis; female gender was associated with worse local control (p=0.001). Also in univariate analysis of overall survival, there was a trend for worse survival in females, too (p=0.07). 

Conclusion: This small study may give some idea about utilizing different tracking ways for CyberKnife® with less toxicity. 


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Primary Language en
Subjects Medicine
Journal Section Research article
Authors

Author: Ebru ATASEVER AKKAŞ (Primary Author)
Country: Turkey


Author: Ebru KARAKAYA

Author: Gonca ALTINIŞIK İNAN

Author: Yasemin GÜZLE ADAŞ

Author: Ömer YAZICI

Author: Esra KEKİLLİ

Author: Ferhat KIRAN

Author: Ferihan ERTAN

Author: Bülent KÜÇÜKPİLAKÇI

Author: Yıldız GÜNEY

Dates

Publication Date : September 1, 2018

Bibtex @research article { josam432680, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2018}, volume = {2}, pages = {324 - 329}, doi = {10.28982/josam.432680}, title = {Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience}, key = {cite}, author = {Atasever Akkaş, Ebru and Karakaya, Ebru and Altınışık İnan, Gonca and Güzle Adaş, Yasemin and Yazıcı, Ömer and Kekilli, Esra and Kıran, Ferhat and Ertan, Ferihan and Küçükpilakçı, Bülent and Güney, Yıldız} }
APA Atasever Akkaş, E , Karakaya, E , Altınışık İnan, G , Güzle Adaş, Y , Yazıcı, Ö , Kekilli, E , Kıran, F , Ertan, F , Küçükpilakçı, B , Güney, Y . (2018). Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience . Journal of Surgery and Medicine , 2 (3) , 324-329 . DOI: 10.28982/josam.432680
MLA Atasever Akkaş, E , Karakaya, E , Altınışık İnan, G , Güzle Adaş, Y , Yazıcı, Ö , Kekilli, E , Kıran, F , Ertan, F , Küçükpilakçı, B , Güney, Y . "Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience" . Journal of Surgery and Medicine 2 (2018 ): 324-329 <https://jsurgmed.com/en/pub/issue/36726/432680>
Chicago Atasever Akkaş, E , Karakaya, E , Altınışık İnan, G , Güzle Adaş, Y , Yazıcı, Ö , Kekilli, E , Kıran, F , Ertan, F , Küçükpilakçı, B , Güney, Y . "Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience". Journal of Surgery and Medicine 2 (2018 ): 324-329
RIS TY - JOUR T1 - Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience AU - Ebru Atasever Akkaş , Ebru Karakaya , Gonca Altınışık İnan , Yasemin Güzle Adaş , Ömer Yazıcı , Esra Kekilli , Ferhat Kıran , Ferihan Ertan , Bülent Küçükpilakçı , Yıldız Güney Y1 - 2018 PY - 2018 N1 - doi: 10.28982/josam.432680 DO - 10.28982/josam.432680 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 324 EP - 329 VL - 2 IS - 3 SN - -2602-2079 M3 - doi: 10.28982/josam.432680 UR - https://doi.org/10.28982/josam.432680 Y2 - 2018 ER -
EndNote %0 Journal of Surgery and Medicine Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience %A Ebru Atasever Akkaş , Ebru Karakaya , Gonca Altınışık İnan , Yasemin Güzle Adaş , Ömer Yazıcı , Esra Kekilli , Ferhat Kıran , Ferihan Ertan , Bülent Küçükpilakçı , Yıldız Güney %T Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience %D 2018 %J Journal of Surgery and Medicine %P -2602-2079 %V 2 %N 3 %R doi: 10.28982/josam.432680 %U 10.28982/josam.432680
ISNAD Atasever Akkaş, Ebru , Karakaya, Ebru , Altınışık İnan, Gonca , Güzle Adaş, Yasemin , Yazıcı, Ömer , Kekilli, Esra , Kıran, Ferhat , Ertan, Ferihan , Küçükpilakçı, Bülent , Güney, Yıldız . "Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience". Journal of Surgery and Medicine 2 / 3 (September 2018): 324-329 . https://doi.org/10.28982/josam.432680
AMA Atasever Akkaş E , Karakaya E , Altınışık İnan G , Güzle Adaş Y , Yazıcı Ö , Kekilli E , Kıran F , Ertan F , Küçükpilakçı B , Güney Y . Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience. J Surg Med. 2018; 2(3): 324-329.
Vancouver Atasever Akkaş E , Karakaya E , Altınışık İnan G , Güzle Adaş Y , Yazıcı Ö , Kekilli E , Kıran F , Ertan F , Küçükpilakçı B , Güney Y . Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience. Journal of Surgery and Medicine. 2018; 2(3): 324-329.
IEEE E. Atasever Akkaş , E. Karakaya , G. Altınışık İnan , Y. Güzle Adaş , Ö. Yazıcı , E. Kekilli , F. Kıran , F. Ertan , B. Küçükpilakçı and Y. Güney , "Clinical outcome of stereotactic ablative radiotherapy with CyberKnife® for lung tumors: A single center experience", Journal of Surgery and Medicine, vol. 2, no. 3, pp. 324-329, Sep. 2018, doi:10.28982/josam.432680