Year 2018, Volume 2 , Issue 3, Pages 315 - 319 2018-09-01

Jinekolojik kanserlerde retrospektif üç boyutlu konformal radyoterapi ve yoğunluk ayarlı radyoterapinin dozimetrik karşılaştırılması ve üç boyutlu konformal radyoterapinin akut yan etkileri
Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy

Halil SAĞINÇ [1] , Özgür YILDIRIM [2] , Bahar BALTALARLI [3]


Amaç: Jinekolojik kanserlerde retrospektif üç boyutlu konformal radyoterapi tedavisine ait akut yan etkileri değerlendirmek ve yoğunluk ayarlı radyoterapinin ve üç boyutlu konformal radyoterapinin kemik iliği ve riskli organların dozimetrik olarak karşılaştırmak amaçlanmıştır. 

Yöntemler: Üç boyutlu konformal radyoterapi ile tedavisi tamamlanmış 28 hasta retrospektif olarak değerlendirildi ve hastalar IMRT tekniğine göre yeniden planlandı. Olguların kemik iliği ve kritik organ dozları dozimetrik olarak karşılaştırıldı. Olgularda yan etki değerlendirmesi RTOG toksisite skalası ve yaşam kalitesi Avrupa Kanser Araştırma ve Tedavi Merkezi (EORTC) QLQ30 anketi uygulanarak değerlendirildi. 

Bulgular: Akut yan etkiler değerlendirildiğinde grad 1 alt gastrointestinal (GIS) yan etki 16 (% 57,1) olguda, grad 1 üst GIS yan etki 9 (%32,1) olguda, grad 1 hematolojik yan etki 1 (% 3,6) olguda, grad 1 cilt yan etki 14 (% 50) olguda görüldü. Grad 2 üst GIS yan etki 1 (% 3,6) olguda, grad 2-3 hematolojik yan etki 11 (% 39,3) olguda görüldü. Kemik iliği V20 (p<0,001), kemik iliği V95 (%) (p<0,001)  mesane V40 (p<0,001), mesane ortalama doz (p<0,001), rektum V40 (p<0,001), rektum ortalama doz (p<0,001), ince barsak V40 (p<0,001) yoğunluk ayarlı radyoterapi ile konformal radyoterapiden daha düşük doz aldı.   

Sonuç: IMRT reduce dose to the bone marrow and the normal tissues as compared to 3D-CRT. Üç boyutlu radyoterapi jinekolojik kanserlerde düşük yan etki seviyesiyle kabul edilebilir güvenilir bir tedavidir ve yaşam kalitesini olumsuz etkilemez. Yoğunluk ayarlı radyoterapi kemik iliği ve riskli organ dozlarını konformal radyoterapiye göre daha iyi kısıtlar.


Aim: The study was designed to compare the critical organ and bone marrow doses with three-dimensional conformal radiotherapy plans and intensity-modulated radiotherapy re-treatment plans and to evaluate acute toxicities of three-dimensional conformal radiotherapy for gynecological cancer.

Methods: Twenty-eight patients who underwent conformal radiotherapy (3D-CRT) were evaluated retrospectively and were re- planned according to IMRT technique. The critical organ and bone marrow doses of patients were compared dosimetrically. Evaluation of early side effects was performed using RTOG toxicity scale and European Organization for Research and Treatment of Cancer (EORTC) QLQ30 side effect evaluation questionnaire.

Results: The assessment of early toxicity revealed Grade 1 lower gastrointestinal (GIS) toxicity in 16 (57.1%) patients, grade 1 upper GIS toxicity in 9 (32.1%) patients, grade 1 hematological toxicity in one (3.6%) patients, grade 1 genitourinary toxicity in 15 (53.6%), grade 1 skin toxicity in (50%) 14 patients . One patient (3.6%) had grade 2 upper GIS toxicity, 11 patients (39.3%) had grade 2-3 hematological toxicity. Bone marrow V20 (p<0.001), V95 (%) of bone marrow (p<0.001), urinary bladder V40 (p<0.001), urinary bladder mean dose (p<0.001), rectum V40 (p<0.001), rectum mean dose (p<0.001), small bowel V40 (p<0.001) were received lower doses in the IMRT planning arm than the conformal planning arm.

Conclusion: 3D-CRT is a safe treatment with acceptable low toxicity levels in gynecological cancer patients, and it does not adversely affect quality of life. IMRT reduce dose to the bone marrow and the normal tissues as compared to 3D-CRT.


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Primary Language en
Subjects Medicine
Journal Section Research article
Authors

Author: Halil SAĞINÇ (Primary Author)
Institution: Denizli Devlet Hastanesi, Radyasyon Onkolojisi
Country: Turkey


Author: Özgür YILDIRIM
Institution: Manisa Devlet Hastanesi, Radyasyon Onkolojisi
Country: Turkey


Author: Bahar BALTALARLI
Institution: Pamukkale Üniversitesi Tıp Fakültesi, Radyasyon Onkolojisi
Country: Turkey


Dates

Publication Date : September 1, 2018

Bibtex @research article { josam421803, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2018}, volume = {2}, pages = {315 - 319}, doi = {10.28982/josam.421803}, title = {Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy}, key = {cite}, author = {Sağınç, Halil and Yıldırım, Özgür and Baltalarlı, Bahar} }
APA Sağınç, H , Yıldırım, Ö , Baltalarlı, B . (2018). Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy . Journal of Surgery and Medicine , 2 (3) , 315-319 . DOI: 10.28982/josam.421803
MLA Sağınç, H , Yıldırım, Ö , Baltalarlı, B . "Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy" . Journal of Surgery and Medicine 2 (2018 ): 315-319 <https://jsurgmed.com/en/pub/issue/36726/421803>
Chicago Sağınç, H , Yıldırım, Ö , Baltalarlı, B . "Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy". Journal of Surgery and Medicine 2 (2018 ): 315-319
RIS TY - JOUR T1 - Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy AU - Halil Sağınç , Özgür Yıldırım , Bahar Baltalarlı Y1 - 2018 PY - 2018 N1 - doi: 10.28982/josam.421803 DO - 10.28982/josam.421803 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 315 EP - 319 VL - 2 IS - 3 SN - -2602-2079 M3 - doi: 10.28982/josam.421803 UR - https://doi.org/10.28982/josam.421803 Y2 - 2018 ER -
EndNote %0 Journal of Surgery and Medicine Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy %A Halil Sağınç , Özgür Yıldırım , Bahar Baltalarlı %T Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy %D 2018 %J Journal of Surgery and Medicine %P -2602-2079 %V 2 %N 3 %R doi: 10.28982/josam.421803 %U 10.28982/josam.421803
ISNAD Sağınç, Halil , Yıldırım, Özgür , Baltalarlı, Bahar . "Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy". Journal of Surgery and Medicine 2 / 3 (September 2018): 315-319 . https://doi.org/10.28982/josam.421803
AMA Sağınç H , Yıldırım Ö , Baltalarlı B . Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy. J Surg Med. 2018; 2(3): 315-319.
Vancouver Sağınç H , Yıldırım Ö , Baltalarlı B . Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy. Journal of Surgery and Medicine. 2018; 2(3): 315-319.
IEEE H. Sağınç , Ö. Yıldırım and B. Baltalarlı , "Acute toxicities of three-dimensional conformal radiotherapy in the treatment of gynecological cancer, and retrospective dosimetric comparison of three dimensional conformal radiotherapy and invers intensity-modulated radiotherapy", Journal of Surgery and Medicine, vol. 2, no. 3, pp. 315-319, Sep. 2018, doi:10.28982/josam.421803