Year 2018, Volume 2 , Issue 3, Pages 361 - 363 2018-09-01

Mantle hücreli lenfoma ile birliktelik gösteren bir langerhans hücreli histiyositozis olgusu
A case of langerhans cell histiocytosis associated with mantle cell lymphoma

Gülen Gül [1] , Mehmet Ali Özcan [2] , Fatih Demirkan [3] , Sermin Özkal [4]


Langerhans hücrelerinin neoplastik klonal proliferasyonundan oluşan Langerhans Hücreli Histiyositozis (LHH) nadir durumlarda, özellikle lenfomalar olmak üzere çeşitli malign neoplaziler ile ilişkili olabilir. Literatürdeki bazı çalışmalarda MHL tanısı öncesi ve sonrasında, beklenmeyen sayıda ikincil malignite olduğu görülmüştür. Burada aynı lenf nodunda LHH ve mantle hücreli lenfoma (MHL) birlikteliği olan bir olgu sunulmaktadır. Bildiğimiz kadarıyla, bu olgu MHL ve LHH birlikteliği olan ikinci vakadır. 

Langerhans Cell Histiocytosis (LCH), which is caused by neoplastic clonal proliferation of Langerhans cells, may be associated with various malignant neoplasms, especially lymphomas, in rare cases. In literature some studies observed an unexpected number of second malignancies, both prior to and after the diagnosis of MCL. Here, we report a case with concurrent LCH and mantle cell lymphoma (MCL) in a same lymph node. To the best of our knowledge, this is the second reported case of LCH associated with mantle cell lymphoma in a lymph node.

  • 1. Christie LJ, Evans AT, Bray SE, Smith ME, Kernohan NM, Levison DA, et al. Lesions resembling Langerhans cell histiocytosis in association with other lymphoproliferative disorders: a reactive or neoplastic phenomenon?. Hum Pathol. 2006 Jan;37(1):32-9.
  • 2. Lian C, Lu Y, Shen S. Langerhans cell histiocytosis in adults: a case report and review of the literature. Oncotarget. 2016 Apr 5;7(14):18678-83.
  • 3. Benharroch D, Guterman G, Levy I, Shaco-Levy R. High content of Langerhans cells in malignant lymphoma-incidence and significance. Virchows Arch. 2010 Jul;457(1):63-7.
  • 4. Roufosse C, Lespagnard L, Salés F, Bron D, Dargent JL. Langerhans' cell histiocytosis associated with simultaneous lymphocyte predominance Hodgkin's disease and malignant melanoma. Hum Pathol. 1998 Feb;29(2):200-1.
  • 5. Egeler RM, Neglia JP, Puccetti DM, Brennan CA, Nesbit ME. Association of Langerhans cell histiocytosis with malignant neoplasms. Cancer. 1993 Feb 1;71(3):865-73.
  • 6. Feldman AL, Berthold F, Arceci RJ, Abramowsky C, Shehata BM, Mann KP, et al. Clonal relationship between precursor T-lymphoblastic leukaemia/lymphoma and Langerhans-cell histiocytosis. Lancet Oncol. 2005 Jun;6(6):435-7.
  • 7. Moraveji S, Tonk V, Gaur S, Torabi A. Langerhans cell histiocytosis and diffuse large B-cell lymphoma with tetrasomy of PBX1 gene and t[14;19]: two entities in one lymph node. Pathology. 2016 Dec;48(7):728-31.
  • 8. West DS, Dogan A, Quint PS, Tricker-Klar ML, Porcher JC, Ketterling RP, et al. Clonally related follicular lymphomas and Langerhans cell neoplasms: expanding the spectrum of transdifferentiation. Am J Surg Pathol. 2013 Jul;37(7):978-86.
  • 9. Greaves WO, Bueso-Ramos C, Fayad L. Classical Hodgkin's lymphoma associated with Langerhans cell histiocytosis: multiagent chemotherapy resulted in histologic resolution of both the classical Hodgkin's lymphoma and Langerhans cell proliferation components. J Clin Oncol. 2011 Feb 1;29(4):e76-8.
  • 10. Pina-Oviedo S, Medeiros LJ, Li S, Khoury JD, Patel KP, Alayed K, et al. Langerhans cell histiocytosis associated with lymphoma: an incidental finding that is not associated with BRAF or MAP2K1 mutations. Mod Pathol. 2017 May;30(5):734-44.
  • 11. Das DK, Sheikh ZA, Alansary TA, Amir T, Al-Rabiy FN, Junaid TA. A case of Langerhans' cell histiocytosis associated with Hodgkin's lymphoma: Fine-needle aspiration cytologic and histopathological features. Diagn Cytopathol. 2016 Feb;44(2):128-32.
  • 12. Zeng K, Wang Z, Ohshima K, Liu Y, Zhang W, Wang L, et al. BRAF V600E mutation correlates with suppressive tumor immune microenvironment and reduced disease-free survival in Langerhans cell histiocytosis. Oncoimmunology. 2016 Jun 14;5(7):e1185582.
  • 13. Nakamine H, Yamakawa M, Yoshino T, Fukumoto T, Enomoto Y, Matsumura I. Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis. J Clin Exp Hematop. 2016;56(2):109-18.
  • 14. Vose JM. Mantle cell lymphoma: 2015 update on diagnosis, risk-stratification, and clinical management. Am J Hematol. 2015 Aug;90(8):739-45.
  • 15. Barista I, Cabanillas F, Romaguera JE, Khouri IF, Yang Y, Smith TL, et al. Is there an increased rate of additional malignancies in patients with mantle cell lymphoma? Ann Oncol. 2002 Feb;13(2):318-22.
Primary Language en
Subjects Medicine
Journal Section Case report
Authors

Orcid: 0000-0001-5750-0098
Author: Gülen Gül (Primary Author)
Institution: Department of Pathology, Tepecik Education and Research Hospital, Izmir
Country: Turkey


Author: Mehmet Ali Özcan
Institution: Department of Hematology, Dokuz Eylul University Faculty of Medicine, Izmir
Country: Turkey


Author: Fatih Demirkan
Institution: Department of Hematology, Dokuz Eylul University Faculty of Medicine, Izmir
Country: Turkey


Author: Sermin Özkal
Institution: Department of Pathology, Dokuz Eylul University Faculty of Medicine, Izmir
Country: Turkey


Dates

Publication Date : September 1, 2018

Bibtex @case report { josam403513, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2018}, volume = {2}, pages = {361 - 363}, doi = {10.28982/josam.403513}, title = {A case of langerhans cell histiocytosis associated with mantle cell lymphoma}, key = {cite}, author = {Gül, Gülen and Özcan, Mehmet Ali and Demirkan, Fatih and Özkal, Sermin} }
APA Gül, G , Özcan, M , Demirkan, F , Özkal, S . (2018). A case of langerhans cell histiocytosis associated with mantle cell lymphoma . Journal of Surgery and Medicine , 2 (3) , 361-363 . DOI: 10.28982/josam.403513
MLA Gül, G , Özcan, M , Demirkan, F , Özkal, S . "A case of langerhans cell histiocytosis associated with mantle cell lymphoma" . Journal of Surgery and Medicine 2 (2018 ): 361-363 <https://jsurgmed.com/en/pub/issue/36726/403513>
Chicago Gül, G , Özcan, M , Demirkan, F , Özkal, S . "A case of langerhans cell histiocytosis associated with mantle cell lymphoma". Journal of Surgery and Medicine 2 (2018 ): 361-363
RIS TY - JOUR T1 - A case of langerhans cell histiocytosis associated with mantle cell lymphoma AU - Gülen Gül , Mehmet Ali Özcan , Fatih Demirkan , Sermin Özkal Y1 - 2018 PY - 2018 N1 - doi: 10.28982/josam.403513 DO - 10.28982/josam.403513 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 361 EP - 363 VL - 2 IS - 3 SN - -2602-2079 M3 - doi: 10.28982/josam.403513 UR - https://doi.org/10.28982/josam.403513 Y2 - 2018 ER -
EndNote %0 Journal of Surgery and Medicine A case of langerhans cell histiocytosis associated with mantle cell lymphoma %A Gülen Gül , Mehmet Ali Özcan , Fatih Demirkan , Sermin Özkal %T A case of langerhans cell histiocytosis associated with mantle cell lymphoma %D 2018 %J Journal of Surgery and Medicine %P -2602-2079 %V 2 %N 3 %R doi: 10.28982/josam.403513 %U 10.28982/josam.403513
ISNAD Gül, Gülen , Özcan, Mehmet Ali , Demirkan, Fatih , Özkal, Sermin . "A case of langerhans cell histiocytosis associated with mantle cell lymphoma". Journal of Surgery and Medicine 2 / 3 (September 2018): 361-363 . https://doi.org/10.28982/josam.403513
AMA Gül G , Özcan M , Demirkan F , Özkal S . A case of langerhans cell histiocytosis associated with mantle cell lymphoma. J Surg Med. 2018; 2(3): 361-363.
Vancouver Gül G , Özcan M , Demirkan F , Özkal S . A case of langerhans cell histiocytosis associated with mantle cell lymphoma. Journal of Surgery and Medicine. 2018; 2(3): 361-363.
IEEE G. Gül , M. Özcan , F. Demirkan and S. Özkal , "A case of langerhans cell histiocytosis associated with mantle cell lymphoma", Journal of Surgery and Medicine, vol. 2, no. 3, pp. 361-363, Sep. 2018, doi:10.28982/josam.403513