Hybrid repair of early aortobifemoral graft occlusion in a patient with antiphospholipid syndrome: A case report
Hybrid repair of graft occlusion in APS
Keywords:
Aortobifemoral bypass, Graft thrombosis, Hybrid procedure, Antiphospholipid syndromeAbstract
Complete thrombosis of an aortic segment and unilateral graft limb after aortobifemoral bypass is a rare but severe complication. We report the case of a 41-year-old female patient who presented 2.5 months after aortobifemoral bypass for Leriche syndrome with recurrent claudication and ischemic rest pain. Imaging revealed complete thrombosis of the proximal aortic segment and the right iliac graft limb. A hybrid repair was performed consisting of bilateral groin incisions, thrombectomy, endarterectomy, and placement of kissing covered stents. Postoperative recovery was uneventful, with restored perfusion and good graft patency on follow-up. Thrombophilia screening demonstrated antiphospholipid syndrome, which was considered an important contributor to the early graft failure. This case illustrates that hybrid repair can be a safe and effective option for early aortobifemoral graft occlusion and highlights the importance of systemic evaluation for prothrombotic disorders in young patients presenting with unexplained thrombosis.
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Dellehunt RE, Manna B. Aortofemoral bypass. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. Available from: https://www.ncbi.nlm.nih.gov/books/NBK542328/ (accessed 2 April 2025).
Dormandy JA, Rutherford RB; TASC Working Group. Management of peripheral arterial disease (PAD): TransAtlantic Inter-Society Consensus (TASC). J Vasc Surg. 2000;31(1 Pt 2):S1–296.
Nevelsteen A, Suy R. Graft occlusion following aortofemoral Dacron bypass. Ann Vasc Surg. 1991;5:32–37. DOI: https://doi.org/10.1007/BF02021774
Crawford ES, Bomberger RA, Glaeser DH, Saleh SA, Ro JWL. Aortoiliac occlusive disease: factors influencing survival and function following reconstructive operation over a 25-year period. Surgery. 1981;90(6):1055–67.
Brown KN, Muco E, Leriche GL. Leriche syndrome. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. Available from: https://www.ncbi.nlm.nih.gov/books/ (accessed 4 April 2025).
Erdoes LS, Bernhard VM, Berman SS. Aortofemoral graft occlusion: strategy and timing of reoperation. Vascular. 1995;3:277–83. DOI: https://doi.org/10.1177/096721099500300306
TransAtlantic Inter-Society Consensus (TASC) II Working Group. Management of peripheral arterial disease (PAD). Section D: chronic critical limb ischaemia. Eur J Vasc Endovasc Surg. 2007;33(Suppl 1):S144–243.
Robicsek F, Daugherty HK, Mullen DC, Masters TN, Narbay D, Sanger PW. Effect of continued cigarette smoking on the patency of synthetic vascular grafts in Leriche syndrome. J Thorac Cardiovasc Surg. 1975;70:107–13. DOI: https://doi.org/10.1016/S0022-5223(19)40386-3
Imparato AM, Bracco A, Kim GE, Zeff R. Intimal and neointimal fibrous proliferation causing failure of arterial reconstructions. Surgery. 1972;72:1007–17.
Cohn LH, Moore WS, Hufnagel AD. Extra-abdominal management of late aortofemoral graft thrombosis. Surgery. 1970;67(5):775–9.
Frisch N, Bour P, Berg P, Fiévé G, Frisch R. Long-term results of thrombectomy for late occlusions of aortofemoral bypass. Ann Vasc Surg. 1991;5:16–20. DOI: https://doi.org/10.1007/BF02021771
Brewster DC, Meier GH, Darling RC, Moncure AC, Lamuraglia GM, Abbott WM. Reoperation for aortofemoral graft limb occlusion: optimal methods and long-term results. J Vasc Surg. 1987;5:363–74. DOI: https://doi.org/10.1067/mva.1987.avs0050363
De Donato G, Bosiers M, Setacci F, Deloose K, Galzerano G, Verbist J, et al. 24-month data from BRAVISSIMO: large-scale registry on iliac stenting for TASC A–D lesions. Ann Vasc Surg. 2015;29:738–50. DOI: https://doi.org/10.1016/j.avsg.2014.12.027
Greiner A, Dessl A, Klein-Weigel P, Neuhauser B, Perkmann R, Waldenberger P, et al. Kissing stents for treatment of complex aortoiliac disease. Eur J Vasc Endovasc Surg. 2003;26:161–5. DOI: https://doi.org/10.1053/ejvs.2002.1882
Abello N, Kretz B, Picquet J, Magnan PE, Hassen-Khodja R, Chevalier J, et al. Long-term results of stenting of the aortic bifurcation. Ann Vasc Surg. 2012;26:521–6. DOI: https://doi.org/10.1016/j.avsg.2011.05.046
Hong JL, Hou YT, Lin PC, Chen YL, Chien DS, Yiang GT, et al. Antiphospholipid syndrome-induced Leriche syndrome in a man with lower-limb sensory and motor defect. J Cardiovasc Dev Dis. 2021;8(9):104. DOI: https://doi.org/10.3390/jcdd8090104
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Copyright (c) 2026 Laurens Vermylen, Geert Daenen, Patrick Stabel, Jo Avet, Karen Peeters
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