Sexual dysfunction and associated risk factors in multiple sclerosis

Authors

Keywords:

multiple sclerosis, sexual dysfunction, cognitive impairment, depression

Abstract

Aim: Sexual dysfunction (SD) is quite common in multiple sclerosis (MS), and exhibits a multifactorial pattern. This study was set out to evaluate the frequency of SD and explore the related factors to support the quality of MS patients’ lives. Methods: This cross-sectional study included 96 volunteer RRMS patients between 18 and 60 years of age who were diagnosed with MS according to the Mc Donald criteria between 2018 and 2019 in our hospital. Multiple sclerosis intimacy and sexuality questionnaire-19 (MSISQ-19), Arizona Sexual Experience Scale (ASEX), Multiple Sclerosis Inventory of Cognition (MUSIC) and Beck Depression Inventory (BDI) questionnaires were used. Results: Mean age of the patients was 38.46 (8.47) (min-max:20 – 60 years) years, and mean disease period was 77.02 (70.62) (3–324 months) months. Mean Extended Disability Status Scale (EDSS) score was 2.1 (1.33) (0-5) with a standard deviation of 80.5%. A negative correlation was observed between MUSIC cognitive and EDSS (P=0.017; r=-0.273), and BDI scores (P=0.003; r=-0.306). A significant and positive correlation was detected between MSISQ score (P<0.001; r=0.476) and BDI (P<0.001; r=0.529) in MUSIC fatigue test results. A negative and poor correlation was found between MUSIC fatigue and MUSIC cognitive score (P<0.001; r=-0.365). In patients with depression, mean MUSIC cognitive scores were lower (P=0.009), while MUSIC fatigue scores were higher (P<0.001). Age, educational status, presence of secondary SD were independent risk factors. Conclusion: SD, a quite common condition in MS, may be decreased to increase the quality of lives of patients through treatment of psychosocial factors associated with cognitive state.

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References

Chalah MA, Ayache SS. Cognitive behavioral therapies and multiple sclerosis fatigue: A review of literature. Journal of Clinical Neuroscience. 2018;52:1-4.

Çelik DB, Poyraz EÇ, Bingöl A, İdiman E, Özakbaş S, Kaya D. Sexual dysfunction in multiple sclerosis: Gender differences. Journal of the Neurological Sciences. 2013;324:17-20.

Dupont S. Multiple sclerosis and sexual functioning -a review. Clin Rehabil. 1995;9:135-41.

Dunya CP, Tulek Z, Uchiyama T, Haslam C, Panicker JN. Systematic review of the prevalence, symptomatology and management options of sexual dysfunction in women with multiple sclerosis. Neurourology and Urodynamics. 2019;39:83-95.

Demirkiran M, Sarica Y, Uguz S, Yerdelen D, Aslan K. Multiple sclerosis patients with and without sexual dysfunction: are there any differences? Mult Scler. 2006;12:209-14.

Zorzon M, Zivadinov R, Bosco A, Hocking JS, De Livera AM, Taylor KL, et al. Sexual dysfunction in multiple sclerosis: a case–control study. I. Frequency and comparison of groups. Mult Scler. 1999;5:418-27.

Zivadinov R, Zorzon M, Bosco A, Bragadin LM, Moretti R, Bonfigli L, et al. Sexual Disfunction and Associated Risk Factors in Multiple Sclerosis II. Correlation analysis. Mult Scler. 1999;5:428-31.

Drulovic J, Kisic Tepavcevic D, Pekmezovic T. Epidemiology, diagnosis and management of sexual dysfunction in multiple sclerosis. Acta Neurologica Belgica. 2020;120:791-7.

Kurtzke JF. Rating neurologic impairment in multiple sclerosis: an expanded dis- ability status scale (EDSS). Neurology. 1983;33:1444-52.

Tudor KI, Panicker JN. Management of erectile dysfunction in neurological patients. In: Minhas S, Mulhall J, editors. Male Sexual Dysfunction: A Clinical Guide: John Wiley & Sons, Ltd;2017.

McGahuey CA, Gelenberg AJ, Francisco AL, Delgado PL, McKnight KM, Manber R. The Arizona Sexual Experience Scale (ASEX): reliability and validity. J Sex Marital Ther. 2000;26:25-40.

Calabrese P, Kalbe E, Kessler J. Ein neuropsychologisches Screening zur Erfassung kognitiver Störungen bei MS-Patienten: das Sklerose Inventarium Cognition (MUSIC). Neuropsychologia: An International Journal in Behavioural and Cognitive Neuroscience. 2004;30:384-8.

Hulter BM, Lundberg PO. Sexual function in women with advanced multiple sclerosis. J Neurol Neurosurg Psychiatry. 1995;59:83-6.

Calabro RS, Russo M, Dattola V, Luca RD, Leo A, Grisolaghi J, et al. Sexual Function in Young Individuals with Multiple Sclerosis: Does Disability Matter? J Neurosci Nurs. 2018;50:161-6.

Tepavcevic DK, Kostic J, Basuroski ID, Stojsavljevic N, Pekmezovic T, Drulovic J. The impact of sexual dysfunction on the quality of life measured by MSQoL-54 in patients with multiple sclerosis. Mult Scler. 2008;14:1131-6.

Kisic-Tepavcevic D, Pekmezovic T, Trajkovic G, Stojsavljevic N, Dujmovic I, Mesaros S, et al. Sexual dysfunction in multiple sclerosis: a 6-year follow-up study. J Neurol Sci. 2015;358:317–23.

Ashtari F, Rezvani R, Afshar H. Sexual dysfunction in women with multiple sclerosis: dimensions and contributory factors. J Res Med Sci. 2014;19:228-33.

Hösl KM, Deutsch M, Wang R, Roy S, Winder K, Niklewski G, et al. Sexual dysfunction seems to trigger depression in female multiple sclerosis patients. Eur Neurol. 2018;80:34‐41.

Solmaz V, Ozlece HK, Him A, Güneş A, Cordano C, Aksoy D, et al. Evaluation of the association between sexual dysfunction and demyelinating plaque location and number in female multiple sclerosis patients. Neurol Res. 2018;40:683-8.

Gava G, Visconti M, Salvi F, Bartolomei I, Seracchioli R, Meriggiola MC. Prevalence and psychopathological determinants of sexual dysfunction and related distress in women with and without multiple sclerosis. J Sex Med. 2019;16:833-42.

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Published

2020-09-01

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Research Article

How to Cite

1.
Köseoğlu M, Gözübatık Çelik RG, Tutuncu M, Bingöl A, Erbas B, Deringöl D, Ataklı D. Sexual dysfunction and associated risk factors in multiple sclerosis. J Surg Med [Internet]. 2020 Sep. 1 [cited 2022 Aug. 10];4(9):779-83. Available from: https://jsurgmed.com/article/view/800830