Impact of oral immunonutrition on functional outcomes in patients who underwent radical prostatectomy for prostate cancer

Sinan Çelen; Yusuf Özlülerden

doi:10.28982/josam.775192

Authors

Sinan Çelen https://orcid.org/0000-0003-4309-2323
Yusuf Özlülerden https://orcid.org/0000-0002-6467-0930

DOI:

https://doi.org/10.28982/josam.775192

Keywords:

Nutrition, prostate cancer, Urinary incontinence

Abstract

Aim: The effect of oral nutritional support on prostate cancer (PCa), especially the functional outcomes, has been severely questioned. We present the results of a controlled trial to determine the effects of oral nutritional support on functional outcomes after radical prostatectomy. Methods: This is a prospectively designed, randomized controlled trial to evaluate oncological outcomes in the initial period and functional outcomes in the third and sixth months, but the data were obtained retrospectively. Thirty-six patients who underwent laparoscopic radical prostatectomy performed by a single surgeon between October 2017 and August 2018 were included in the study. Eighteen were started on oral immunonutrition (Oral-Impact, Nestle, 3 × 237 ml per day for seven days at home) in the postoperative period for 6 months and 18 control patients received elemental nutrition support without immune-nutrition components. Results: There were no significant differences in demographic and baseline characteristics between the groups. There was no wound infection, urinary tract infection, urinary extravasation, hem-o-lock clip migration to bladder, urinoma, or infected lymphocele after surgery in either group. Continence rates at the third and sixth months and potency rates (P=0.630, P=0.37, respectively) six months after radical prostatectomy were similar. Despite the similarity in both continence rates, they were numerically in favor of the study group. Conclusion: Immunonutrition is associated with early recovery of stress urinary incontinence (SUI) following radical prostatectomy but there was no association between immunonutrition, postoperative morbidity or infectious complications. However, further clinical trials are needed to confirm these promising results.

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