Radiological approach to multinodular and vacuolating neuronal tumor: Two case report

Radiological approach to MVNT: Two case report



magnetic resonance imaging, multinodular, neuronal, tumor, vacuolating


Multinodular and vacuolating neuronal tumors (MVNT) are indolent, low-grade, superficial neuronal tumors of the cerebrum that consist only of neuronal cells in adults. They were first reported in 2013 by Huse et al. and defined by the World Health Organization in 2016. MVNT is characterized by vacuolated tumor nodules with glial and/or neuronal differentiation histopathologically. MVNT is most commonly located in the temporal lobe. Radiologically, it has a subcortical, soap-bubble morphology, sometimes extending to the cortex, and is almost as hyperintense as cerebrospinal fluid on T2-weighted images. Its signal is not suppressed on the FLAIR sequence, and there is no diffusion restriction on diffusion-weighted images. Usually, there is no enhancement after gadolinium injections, but a few reports show weak enhancement in the literature. In the first case, we present a 22-year-old female with MVNT who underwent MRI for a complaint of dizziness which was detected incidentally. MRI showed a clustered multinodular lesion in the left superior frontal gyrus that was hyperintense on T2-weighted/FLAIR series and isointense with gray matter on T1-weighted images. There was no diffusion restriction or contrast enhancement on MRI. In the second case, a 51-year-old female with complaints of numbness and pain in her left arm had an MRI that showed a lesion in the right cerebral hemisphere at the temporoparietal junction. The lesion did not cause edema or mass effect and was distributed in the cortical-subcortical area. The lesion was hyperintense in T2-weighted and FLAIR series and consisted of many millimetric nodular components in close intensity with gray matter in the T1-weighted series. No contrast enhancement was detected. Knowing the characteristic imaging findings of MVNT is important in avoiding aggressive diagnosis and treatment approaches in asymptomatic cases. In conclusion, MVNT is a newly identified tumor that appears hyperintense on the FLAIR sequence and should not be operated on.


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Gökçe E. Magnetic resonance imaging findings of two cases with multinodular and vacuolating neuronal tumor. Acta Neurol Belg. 2020;120(2):457-61. DOI:

Nunes RH, Hsu CC, da Rocha AJ, do Amaral LLF, Godoy LFS, Watkins TW, et al. Multinodular and vacuolating neuronal tumor of the cerebrum: a new “leave me alone” lesion with a characteristic imaging pattern. AJNR Am J Neuroradiol. 2017;38(10):1899-904. DOI:

Louis DN, Perry A, Reifenberger G, Von Deimling A, Figarella-Branger D, Cavenee WK, et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol. 2016;131(6):803-20. DOI:

Thom M, Liu J, Bongaarts A, Reinten RJ, Paradiso B, Jäger HR, et al. Multinodular and vacuolating neuronal tumors in epilepsy: dysplasia or neoplasia? Brain Pathol. 2018;28(2):155-71. DOI:

Alsufayan R, Alcaide-Leon P, De Tilly LN, Mandell DM, Krings T. Natural history of lesions with the MR imaging appearance of multinodular and vacuolating neuronal tumor. Neuroradiology. 2017;59(9):873-83. DOI:

Huse JT, Edgar M, Halliday J, Mikolaenko I, Lavi E, Rosenblum MK. Multinodular and vacuolating neuronal tumors of the cerebrum: 10 cases of a distinctive seizure‐associated lesion. Brain Pathol. 2013;23(5):515-24. DOI:

Fukushima S, Yoshida A, Narita Y, Arita H, Ohno M, Miyakita Y, et al. Multinodular and vacuolating neuronal tumor of the cerebrum. Brain Tumor Pathol. 2015;32(2):131-6. DOI:

Bodi I, Curran O, Selway R, Elwes R, Burrone J, Laxton R, et al. Two cases of multinodular and vacuolating neuronal tumour. Acta Neuropathol Commun. 2014;2(1):1-10. DOI:

De Wandeler T, De Brucker Y, Jansen A, Vanderhasselt T. Multinodular and vacuolating neuronal tumor of the cerebrum (MVNT): do not touch. Acta Neurol Belg. 2020;120(3):747-8. DOI:

Yamaguchi M, Komori T, Nakata Y, Yagishita A, Morino M, Isozaki E. Multinodular and vacuolating neuronal tumor affecting amygdala and hippocampus: a quasi‐tumor? Pathol Int. 2016;66(1):34-41. DOI:

Agarwal A, Lakshmanan R, Devagnanam I, Bynevelt M. Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: Does the Name Require Review? AJNR Am J Neuroradiol. 2019;40(12):69-70. DOI:

Becker AJ, Wiestler OD, Figarella-Branger D, Blumcke I. Ganglioglioma and gangliocytoma. In: Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, editors. WHO Classification of Tumours of the Central Nervous System. 4th ed. Lyon: International Agency for Research on Cancer; 2007. pp. 103–5.

Daumas-Duport C, Varlet P. Dysembryoplastic neuroepithelial tumors. Rev Neurol. 2003;159:622-36.

Meroni A, Galli C, Bramerio M, Tassi L, Colombo N, Cossu M, et al. Nodular heterotopia: a neuropathological study of 24 patients undergoing surgery for drug‐resistant epilepsy. Epilepsia. 2009;50(1):116-24. DOI:






Case Report

How to Cite

Ocak Karataş Şükrüye F, Beyhan M, Gökçe E. Radiological approach to multinodular and vacuolating neuronal tumor: Two case report: Radiological approach to MVNT: Two case report. J Surg Med [Internet]. 2023 Jun. 22 [cited 2024 Apr. 18];7(6):398-400. Available from: