Yıl 2021, Cilt 5 , Sayı 2, Sayfalar 168 - 173 2021-02-01

Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?

Muzaffer KATAR [1]


Background/Aim: Differentiating COVID-19 positive patients from negative ones with similar symptoms and predicting the course of disease are major problems in COVID-19. For this purpose, we investigated the performance of Eosinophil Chemotactic Factor (CCL11) in COVID-19 and compared complete blood count parameters and indexes. Methods: In this retrospective case-control study, ECF/CCL11 values, as well as the clinical, laboratory and radiological data of thirty patients who were diagnosed with Covid-19 between 15 March-15 June 2020 were compared with those of thirty healthy controls. Results: Both patients and controls included 10 (33.30%) females and 20 (66.60%) males with a mean age of 57.2 (15.46) and 60.07 (20.59) years, respectively. Eosinophil counts of the patients on admission (EO1) were significantly lower than those of the controls and one-week later EO2 levels (P<0.001, P=0.004 respectively). EO1, NE1, NE2, PLT2/LYM2, LYM1/CRP1 and LYM2/CRP2 were the most predictive indexes. ECF values of the patients one week after admission (ECF2) were significantly lower than that of controls and admission levels (P=0.046, P=0.011 respectively). ECF2 values differentiated Covid19 negative individuals from patients with 46.70% sensitivity, 93.30% specificity at a cutoff value of ≤45.00 pg/mL. In ROC analysis of ECF2, AUC was 0.702 (P=0.045). Conclusions: Tracking ECF with CBC subsets and indexes may be helpful in the early prediction of severity, diagnosis, and follow up of critical COVID-19 patients in the course of the disease.
Covid-19, ECF, CCL11, Diagnosis, Neutropenia, Lymphopenia
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Birincil Dil en
Konular Acil Tıp, Biyokimya ve Moleküler Biyoloji
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0002-6296-2390
Yazar: Muzaffer KATAR (Sorumlu Yazar)
Kurum: TOKAT GAZİOSMANPAŞA ÜNİVERSİTESİ, TIP FAKÜLTESİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Şubat 2021

Bibtex @araştırma makalesi { josam859368, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2021}, volume = {5}, pages = {168 - 173}, doi = {10.28982/josam.859368}, title = {Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?}, key = {cite}, author = {Katar, Muzaffer} }
APA Katar, M . (2021). Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19? . Journal of Surgery and Medicine , 5 (2) , 168-173 . DOI: 10.28982/josam.859368
MLA Katar, M . "Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?" . Journal of Surgery and Medicine 5 (2021 ): 168-173 <http://jsurgmed.com/tr/pub/issue/60239/859368>
Chicago Katar, M . "Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?". Journal of Surgery and Medicine 5 (2021 ): 168-173
RIS TY - JOUR T1 - Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19? AU - Muzaffer Katar Y1 - 2021 PY - 2021 N1 - doi: 10.28982/josam.859368 DO - 10.28982/josam.859368 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 168 EP - 173 VL - 5 IS - 2 SN - -2602-2079 M3 - doi: 10.28982/josam.859368 UR - https://doi.org/10.28982/josam.859368 Y2 - 2021 ER -
EndNote %0 Journal of Surgery and Medicine Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19? %A Muzaffer Katar %T Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19? %D 2021 %J Journal of Surgery and Medicine %P -2602-2079 %V 5 %N 2 %R doi: 10.28982/josam.859368 %U 10.28982/josam.859368
ISNAD Katar, Muzaffer . "Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?". Journal of Surgery and Medicine 5 / 2 (Şubat 2021): 168-173 . https://doi.org/10.28982/josam.859368
AMA Katar M . Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?. J Surg Med. 2021; 5(2): 168-173.
Vancouver Katar M . Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?. Journal of Surgery and Medicine. 2021; 5(2): 168-173.
IEEE M. Katar , "Could eosinophil chemotactic factor (CCL11) be a useful biomarker of Covid-19?", Journal of Surgery and Medicine, c. 5, sayı. 2, ss. 168-173, Şub. 2021, doi:10.28982/josam.859368