Yıl 2021, Cilt 5 , Sayı 1, Sayfalar 36 - 40 2021-01-01

Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation

Derya KILIÇ [1] , Ömer Tolga GÜLER [2]


Background/Aim: Pregnancy associated placental protein-A (PAPP-A) is a zinc-binding metalloproteinase with a key role in insulin like growth factor (IGF) pathway, and potential atherogenic effects. There is little information in the literature regarding PAPP-A levels in Polycystic ovary syndrome (PCOS). We aimed to investigate the serum PAPP-A levels among non-obese women with PCOS as a cardiovascular risk marker. Methods: Non-obese women of reproductive age (18-35 years of age) diagnosed with PCOS according to Rotterdam Consensus Conference criteria were included in this case-control study. Serum PAPP-A levels were compared with independent samples t-test between two main groups (PCOS and control) and investigated in PCOS subgroups as PCOS patients were further classified according to main phenotypes (hyperandrogenism and oligo-anovulation). Results: A total of 41 women with PCOS and 40 age- and body mass index- matched controls were included in the analysis. The serum PAPP-A levels of the control and PCOS groups, and of PCOS patients with hyperandrogenism were similar (P=0.128, P=0.261, respectively). However, the serum PAPP-A levels of those with oligo-anovulation was higher than those without (P=0.006), and that of women without oligo-anovulation was comparable to that of the control group (P=0.613). Conclusion: Lean and young PCOS women with oligo-anovulation had increased serum levels of PAPP-A when compared to women without. Prospective studies are needed to uncover the long-term cardiovascular risk of elevated PAPP-A levels in PCOS women with oligo-anovulation.
polycystic ovary syndrome;, cardiovascular disease;, pregnancy associated placental protein-A;, PAPP-A
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Konular Kadın Hastalıkları ve Doğum
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0001-8003-9586
Yazar: Derya KILIÇ (Sorumlu Yazar)
Kurum: PAMUKKALE UNIVERSITY
Ülke: Turkey


Orcid: 0000-0001-6673-8604
Yazar: Ömer Tolga GÜLER
Kurum: PAMUKKALE UNIVERSITY, FACULTY OF MEDICINE
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Ocak 2021

Bibtex @araştırma makalesi { josam852160, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2021}, volume = {5}, pages = {36 - 40}, doi = {10.28982/josam.852160}, title = {Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation}, key = {cite}, author = {Kılıç, Derya and Güler, Ömer Tolga} }
APA Kılıç, D , Güler, Ö . (2021). Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation . Journal of Surgery and Medicine , 5 (1) , 36-40 . DOI: 10.28982/josam.852160
MLA Kılıç, D , Güler, Ö . "Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation" . Journal of Surgery and Medicine 5 (2021 ): 36-40 <http://jsurgmed.com/tr/pub/issue/59430/852160>
Chicago Kılıç, D , Güler, Ö . "Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation". Journal of Surgery and Medicine 5 (2021 ): 36-40
RIS TY - JOUR T1 - Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation AU - Derya Kılıç , Ömer Tolga Güler Y1 - 2021 PY - 2021 N1 - doi: 10.28982/josam.852160 DO - 10.28982/josam.852160 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 36 EP - 40 VL - 5 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.852160 UR - https://doi.org/10.28982/josam.852160 Y2 - 2021 ER -
EndNote %0 Journal of Surgery and Medicine Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation %A Derya Kılıç , Ömer Tolga Güler %T Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation %D 2021 %J Journal of Surgery and Medicine %P -2602-2079 %V 5 %N 1 %R doi: 10.28982/josam.852160 %U 10.28982/josam.852160
ISNAD Kılıç, Derya , Güler, Ömer Tolga . "Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation". Journal of Surgery and Medicine 5 / 1 (Ocak 2021): 36-40 . https://doi.org/10.28982/josam.852160
AMA Kılıç D , Güler Ö . Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation. J Surg Med. 2021; 5(1): 36-40.
Vancouver Kılıç D , Güler Ö . Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation. Journal of Surgery and Medicine. 2021; 5(1): 36-40.
IEEE D. Kılıç ve Ö. Güler , "Serum pregnancy-associated placental protein-a (PAPP-A) levels are increased in polycystic ovary syndrome (PCOS) in women with oligo-anovulation", Journal of Surgery and Medicine, c. 5, sayı. 1, ss. 36-40, Oca. 2021, doi:10.28982/josam.852160