1. Journal of Surgery and Medicine
  2. Arşiv
  3. Cilt 5, Sayı 1
Yıl 2021, Cilt 5 , Sayı 1, Sayfalar 17 - 21 2021-01-01

Öz

Background/Aim: Many epidemiological studies describe a relationship between pancreatic cancer (PC) and Diabetes mellitus (DM). However, there are not enough studies investigating the effect of DM on survival of patients with metastatic PC. The purpose of this retrospective study was to investigate the effect of DM and its treatment on survival of patients with metastatic PC who received chemotherapy (CT) as first line treatment. Methods: Patients with metastatic PC who were followed up at the department of medical oncology between 2006 and 2018 were enrolled in this retrospective cohort study. Patients aged 18 years and over, who had metastatic disease at diagnosis and were treated with CT were analyzed. Patients with DM were stratified into two groups based on the history of medical treatments used for DM as follows: Oral antidiabetic (OAD) and OAD + insulin combination. Results: Following results were obtained after analyzing the medical records of 372 patients with metastatic PC, among which 125 (33.6%) had type II DM at the time diagnosis: The median age of the patients was 61 (range: 28-83) years. There were 136 (36.6%) female patients, and the median overall survival (OS) was 9.0 months in patients without DM, and 7.0 months (P=0.023) in those with DM. OS was 8.0 months in diabetic patients using OAD+insulin combination compared to 7.0 months in those receiving OAD (P=0.614) only. Multivariate analysis revealed that the presence of DM [Hazard ratio (HR), 1.43)], Eastern Cooperative Oncology Group Performance Status 3 (HR, 1.62), treatment with gemcitabine+Nab-paclitaxel (HR, 0.29) or folfirinox (HR, 0.46), and CA 19-9 level (HR, 1.01) were factors related to OS. Conclusion: In our study, we observed that the presence of DM adversely affected survival in metastatic PC patients who received CT as first line treatment; however, whether these patients used OAD or OAD+insulin combination did not affect survival.

Anahtar Kelimeler

Pancreas cancer, Diabetes mellitus, fasting plasma glucose, Survival, Prognosis

Kaynakça

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Ayrıntılar

Birincil Dil en
Konular Endokrinoloji ve Metabolizma
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0002-8262-6570
Yazar: Ayşegül SAKİN (Sorumlu Yazar)
Kurum: Van eğitim ve araştırma hastanesi
Ülke: Turkey

Orcid: 0000-0001-9769-2565
Yazar: Suleyman SAHİN
Kurum: van eğitim ve araştırma hastanesş
Ülke: Turkey

Orcid: 0000-0002-1300-3695
Yazar: Abdullah SAKİN
Kurum: Yüzüncü yıl üniversitesi tıp fakültesi
Ülke: Turkey

Orcid: 0000-0002-1300-3695
Yazar: Muhammed ATCİ
Kurum: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL OKMEYDANI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Ülke: Turkey

Orcid: 0000-0002-3982-7465
Yazar: Çağlayan GEREDELİ
Kurum: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL OKMEYDANI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Ülke: Turkey

Orcid: 0000-0002-3960-4982
Yazar: Şener CİHAN
Kurum: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL OKMEYDANI SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Ülke: Turkey
Tarihler

Yayımlanma Tarihi : 1 Ocak 2021

Kaynak Göster

Bibtex @araştırma makalesi { josam840948, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2021}, volume = {5}, pages = {17 - 21}, doi = {10.28982/josam.840948}, title = {Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer}, key = {cite}, author = {Sakin, Ayşegül and Sahin, Suleyman and Sakin, Abdullah and Atci, Muhammed and Geredeli, Çağlayan and Cihan, Şener} }
APA Sakin, A , Sahin, S , Sakin, A , Atci, M , Geredeli, Ç , Cihan, Ş . (2021). Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer . Journal of Surgery and Medicine , 5 (1) , 17-21 . DOI: 10.28982/josam.840948
MLA Sakin, A , Sahin, S , Sakin, A , Atci, M , Geredeli, Ç , Cihan, Ş . "Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer" . Journal of Surgery and Medicine 5 (2021 ): 17-21 <http://jsurgmed.com/tr/pub/issue/59430/840948>
Chicago Sakin, A , Sahin, S , Sakin, A , Atci, M , Geredeli, Ç , Cihan, Ş . "Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer". Journal of Surgery and Medicine 5 (2021 ): 17-21
RIS TY - JOUR T1 - Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer AU - Ayşegül Sakin , Suleyman Sahin , Abdullah Sakin , Muhammed Atci , Çağlayan Geredeli , Şener Cihan Y1 - 2021 PY - 2021 N1 - doi: 10.28982/josam.840948 DO - 10.28982/josam.840948 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 17 EP - 21 VL - 5 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.840948 UR - https://doi.org/10.28982/josam.840948 Y2 - 2021 ER -
EndNote %0 Journal of Surgery and Medicine Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer %A Ayşegül Sakin , Suleyman Sahin , Abdullah Sakin , Muhammed Atci , Çağlayan Geredeli , Şener Cihan %T Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer %D 2021 %J Journal of Surgery and Medicine %P -2602-2079 %V 5 %N 1 %R doi: 10.28982/josam.840948 %U 10.28982/josam.840948
ISNAD Sakin, Ayşegül , Sahin, Suleyman , Sakin, Abdullah , Atci, Muhammed , Geredeli, Çağlayan , Cihan, Şener . "Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer". Journal of Surgery and Medicine 5 / 1 (Ocak 2021): 17-21 . https://doi.org/10.28982/josam.840948
AMA Sakin A , Sahin S , Sakin A , Atci M , Geredeli Ç , Cihan Ş . Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer. J Surg Med. 2021; 5(1): 17-21.
Vancouver Sakin A , Sahin S , Sakin A , Atci M , Geredeli Ç , Cihan Ş . Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer. Journal of Surgery and Medicine. 2021; 5(1): 17-21.
IEEE A. Sakin , S. Sahin , A. Sakin , M. Atci , Ç. Geredeli ve Ş. Cihan , "Effect of type 2 diabetes mellitus on survival in metastatic pancreatic cancer", Journal of Surgery and Medicine, c. 5, sayı. 1, ss. 17-21, Oca. 2021, doi:10.28982/josam.840948
Makalenin Yazarları
Ayşegül SAKİN [1]
Suleyman SAHİN [2]
Abdullah SAKİN [3]
Muhammed ATCİ [4]
Çağlayan GEREDELİ [5]
Şener CİHAN [6]
Makale Gönder
Arşiv
Editör Kurulu
İletişim

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