Yıl 2020, Cilt 4 , Sayı 4, Sayfalar 255 - 258 2020-04-01

Subaraknoid kanama sırasında asidotik kanla oluşan tiroid harabiyeti: Deneysel çalışma
Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study

Ozgur CAGLAR [1] , Erdem KARADENİZ [2] , Sevilay ÖZMEN [3] , Elif ORAL AHISKALIOĞLU [4] , Mehmet AYDİN [5]


Amaç: Metabolik asidoz tiroid fonksiyonlarını olumsuz etkileyebilir. Bu çalışmanın amacı subaraknoid kanama (SAK) sonrası oluşan asidozun tiroid bezinde yaptığı harabiyeti göstermektir.
Yöntemler: Çalışma, son SAK deneylerinden seçilen yirmi tavşan verilerinden seçildi. Tiroid bezlerini analiz etmek için kontrol grubu olarak beş tavşan (n=5) seçildi; 1 cc salin enjekte edilen SHAM grubu (n=5) ve SAK sonrası asidoz oluşan tavşanlardan seçilen on tavşandan oluşan çalışma grubu (n=10) saptadı. Deney prosedürleri öncesinde, deney sırasında ve sonrasında TSH, T3, T4 ve düşük pH değerleri kaydedildi. Tiroid bezlerinin normal ve dejenere epitel hücresinin yoğunlukları stereolojik yöntemler kullanılarak hesaplandı. pH ve tiroid hormon değerleri, dejenere epitel hücre yoğunlukları arasındaki ilişki istatistiksel olarak analiz edildi.
Bulgular: Kanın pH değerleri kontrolde 7,35 (0,037), SHAM'da 7,32 (0,05), SAK grubunda 7,21 (0,012) SAH grubunda tespit edildi. Duvar yüzeyi/hücre yüzeyi olarak hesaplanan foliküllerin milimetre kare başına normal/dejenere epitel hücre sayısı hesaplandı. Normal tiroid foliküllerinde normal epitel hücre sayısı 5.000 (750) idi. Dejenere epitel hücre sayısı normal grupta 50 (9) idi; SHAM grubunda 154 (30) ve çalışma grubunda 460 (80) olarak hesaplandı. Tüm sonuçlar için kontrol grubu ile SHAM ve SAH grupları arasında istatistiksel olarak anlamlı fark bulundu (P<0,001).
Sonuç: SAK'ın en ölümcül komplikasyonlarında biri olan asidoz nörovasküler ağ dejenerasyonuyla tiroid bezinde hasar oluşturabilir.

Aim: Metabolic acidosis can negatively affect thyroid functions. The aim of this study is to show the damage in the thyroid gland caused by acidosis following subarachnoid hemorrhage (SAH).
Methods: Twenty rabbits were chosen from our recent SAH studies. Five healthy rabbits were included in the control group, five were included in the SHAM group, which received 1 ml of saline, and ten rabbits, chosen from SAH-induced animals with decreased blood pH, constituted the study group. TSH, T3, T4 and blood pH values were recorded before, during and after the experimental procedures. Densities of the normal and degenerated epithelial cell of thyroid glands were estimated using stereological methods. The relationship between blood pH and thyroid hormone values, and degenerated epithelial cell densities were analyzed statistically.
Results: pH values of blood were measured as 7.35 (0.037), 7.32 (0.05), and 7.21 (0.012) in the control, SHAM and SAH groups, respectively. The estimation of normal and degenerated epithelial cells per square milimeter of follicles was calculated as wall surface/cell surface. The mean normal epithelial cell count was 5,000 (750) in normal thyroid follicles. Mean degenerated epithelial cells counts were 50 (9) in the normal group, 154 (30) in the SHAM group and 460 (80) in the study group. For all results there was statistically significant difference between the control, SHAM and SAH groups (P<0.001).
Conclusions: Acidosis, one of the most fatal complications of SAH, may damage the thyroid gland with neurovascular network degeneration.
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Birincil Dil en
Konular Cerrahi
Bölüm Araştırma makalesi
Yazarlar

Orcid: 0000-0003-4000-4308
Yazar: Ozgur CAGLAR (Sorumlu Yazar)
Kurum: ATATÜRK ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0001-6319-1754
Yazar: Erdem KARADENİZ
Kurum: ATATÜRK ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0002-1973-6101
Yazar: Sevilay ÖZMEN
Kurum: ATATÜRK ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0003-1234-5973
Yazar: Elif ORAL AHISKALIOĞLU
Kurum: ATATÜRK ÜNİVERSİTESİ
Ülke: Turkey


Orcid: 0000-0002-0383-9739
Yazar: Mehmet AYDİN
Kurum: ATATÜRK ÜNİVERSİTESİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Nisan 2020

Bibtex @araştırma makalesi { josam709558, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {255 - 258}, doi = {10.28982/josam.709558}, title = {Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study}, key = {cite}, author = {Caglar, Ozgur and Karadeniz, Erdem and Özmen, Sevilay and Oral Ahıskalıoğlu, Elif and Aydin, Mehmet} }
APA Caglar, O , Karadeniz, E , Özmen, S , Oral Ahıskalıoğlu, E , Aydin, M . (2020). Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study . Journal of Surgery and Medicine , 4 (4) , 255-258 . DOI: 10.28982/josam.709558
MLA Caglar, O , Karadeniz, E , Özmen, S , Oral Ahıskalıoğlu, E , Aydin, M . "Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study" . Journal of Surgery and Medicine 4 (2020 ): 255-258 <http://jsurgmed.com/tr/pub/issue/53710/709558>
Chicago Caglar, O , Karadeniz, E , Özmen, S , Oral Ahıskalıoğlu, E , Aydin, M . "Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study". Journal of Surgery and Medicine 4 (2020 ): 255-258
RIS TY - JOUR T1 - Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study AU - Ozgur Caglar , Erdem Karadeniz , Sevilay Özmen , Elif Oral Ahıskalıoğlu , Mehmet Aydin Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.709558 DO - 10.28982/josam.709558 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 255 EP - 258 VL - 4 IS - 4 SN - -2602-2079 M3 - doi: 10.28982/josam.709558 UR - https://doi.org/10.28982/josam.709558 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study %A Ozgur Caglar , Erdem Karadeniz , Sevilay Özmen , Elif Oral Ahıskalıoğlu , Mehmet Aydin %T Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 4 %R doi: 10.28982/josam.709558 %U 10.28982/josam.709558
ISNAD Caglar, Ozgur , Karadeniz, Erdem , Özmen, Sevilay , Oral Ahıskalıoğlu, Elif , Aydin, Mehmet . "Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study". Journal of Surgery and Medicine 4 / 4 (Nisan 2020): 255-258 . https://doi.org/10.28982/josam.709558
AMA Caglar O , Karadeniz E , Özmen S , Oral Ahıskalıoğlu E , Aydin M . Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study. J Surg Med. 2020; 4(4): 255-258.
Vancouver Caglar O , Karadeniz E , Özmen S , Oral Ahıskalıoğlu E , Aydin M . Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study. Journal of Surgery and Medicine. 2020; 4(4): 255-258.
IEEE O. Caglar , E. Karadeniz , S. Özmen , E. Oral Ahıskalıoğlu ve M. Aydin , "Destroyed thyroid by acidic blood during subarachnoid hemorrhage: Experimental study", Journal of Surgery and Medicine, c. 4, sayı. 4, ss. 255-258, Nis. 2020, doi:10.28982/josam.709558