Yıl 2019, Cilt 3 , Sayı 6, Sayfalar 437 - 440 2019-06-28

İdiopatik Parkinson hastalığında insülin direnci yorgunluk, hastalık şiddeti ve motor yetersizlik ile ilişkili midir?
Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease?

Gökhan ÖZER [1] , Hatice ADIGÜZEL [2] , Zekiye İpek KATIRCI KIRMACI [3] , Nevin ERGUN [4]


Amaç: Anormal glukoz metabolizmasının, anormal mitokondriyal fonksiyon ve nörodejeneratif süreçler ile potansiyel olarak ilişkili olduğu bilinmektedir. Çalışmanın amacı idiopatik Parkinson hastalığı (İPH) olan hastalarda insulin direnci ile yorgunluk, hastalık şiddeti ve motor yetersizlik ile ilişkisini incelemektir. 

Yöntemler: Çalışmaya üniversite hastanesine başvuran ve nörolog tarafından İPH tanısı alan toplam 50 hasta alındı. Hastaların demografik özellikleri (yaş, cinsiyet, boy, kilo, vücut kitle indeksi (VKİ) kaydedildi. Hastalar insulin direnci (IR) olup olmamasına göre iki gruba ayrıldı. İnsülin direnci olan grup, grup 1 (IR+) (n=30 (10 kadın, 20 erkek, yaş= 66, boy=169 cm, kilo=75 kg, VKI=26,6 kg/m2 (medyan)), insulin direnci olmayan grup, grup 2 (IR-) (n=20 (8 kadın, 12 erkek, yaş=63,5, boy=168 cm, kilo=75 kg, VKI=26,95 kg/m2 (medyan)). İnsülin direncinin değerlendirilmesi için Homeostatic Model of Assessment-Insulin Resistance (HOMA-IR) testi yapıldı. Hastalık şiddeti Modified Hoehn-Yahr skalası ile, motor yetersizlik Birleşik Parkinson Hastalığı Derecelendirme Ölçeği (MDS-UPDRS) skalası ile, yorgunluk ise Yorgunluk Etki Ölçeği ile değerlendirildi. 

Bulgular: MDS-UPDRS skorları IR (+) ve IR (-) olan İPH hasta grupları arasında istatistiksel olarak anlamlı farklılık gösterdi (P=0,034). Modifiye Hoehn - Yahr (P=0,300) ve FSS (P=0,147) skorları açısından gruplar arasında istatistiksel olarak anlamlı farklılık bulunmadı. 

Sonuç: Bu çalışma, İPH hastalarında IR'nin hastalık şiddeti için bir rolü olabileceğini düşündürmektedir. İPH'li hastalarda insülin direnci sorgulanmalı ve tedavi ve rehabilitasyon programında düşünülmelidir.

Aim: Abnormal glucose metabolism is known to potentially correlate abnormal mitochondrial function and neurodegenerative processes. The purpose of the study was to determine the association of insulin resistance on fatigue, the severity of the disease and motor disability in patients with idiopathic Parkinson’s disease (IPD).

Methods: A total of 50 patients diagnosed with IPD by a neurologist from university hospital were enrolled to study. Demographic characteristics (age, gender, height, weight and body mass index (BMI) were recorded. Patients were allocated into two groups by insulin resistance (IR), named insulin resistance (+) as group 1 (IR+) (n=30 (10 female, 20 male), age=66 years, height=169 cm, weight=75 kg, BMI=26.6 kg/m2 (median)) and insulin resistance (-) as group 2 (IR-) (n=20 (8 female, 12 male), age=63.5 years, height=168 cm, weight=75 kg, BMI=26.95 kg/m2 (median)). The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) test was used for assessment of insulin resistance. The disease severity was assessed by the Modified Hoehn and Yahr Scale, motor disability was assessed by Movement Disorders Society-revised Unified PD Rating Scale (MDS-UPDRS) and fatigue was rated by Fatigue Severity Scale (FSS). 

Results: MDS-UPDRS scores were statistically significantly different between the groups of IPD patients with IR(+) and IR(-) (P=0.034). Modified Hoehn - Yahr (P=0.300) and FSS (P=0.147) scores were not statistically significantly different between the same groups.

Conclusion: This study suggests that IR may have a role for disease severity in patients with IPD. In patients with IPD, insulin resistance should be questioned and considered in the treatment and rehabilitation program.

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Orcid: 0000-0003-0039-2350
Yazar: Gökhan ÖZER (Sorumlu Yazar)
Kurum: SANKO UNIVERSITY, FACULTY OF HEALTH SCIENCES
Ülke: Turkey


Orcid: 0000-0001-9323-839X
Yazar: Hatice ADIGÜZEL
Kurum: SANKO UNIVERSITY, FACULTY OF HEALTH SCIENCES
Ülke: Turkey


Orcid: 0000-0001-7225-5123
Yazar: Zekiye İpek KATIRCI KIRMACI
Kurum: SANKO UNIVERSITY, FACULTY OF HEALTH SCIENCES
Ülke: Turkey


Orcid: 0000-0001-6575-7205
Yazar: Nevin ERGUN
Kurum: SANKO UNIVERSITY, FACULTY OF HEALTH SCIENCES
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 28 Haziran 2019

Bibtex @araştırma makalesi { josam521927, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2019}, volume = {3}, pages = {437 - 440}, doi = {10.28982/josam.521927}, title = {Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease?}, key = {cite}, author = {Özer, Gökhan and Adıgüzel, Hatice and Katırcı Kırmacı, Zekiye İpek and Ergun, Nevin} }
APA Özer, G , Adıgüzel, H , Katırcı Kırmacı, Z , Ergun, N . (2019). Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease? . Journal of Surgery and Medicine , 3 (6) , 437-440 . DOI: 10.28982/josam.521927
MLA Özer, G , Adıgüzel, H , Katırcı Kırmacı, Z , Ergun, N . "Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease?" . Journal of Surgery and Medicine 3 (2019 ): 437-440 <http://jsurgmed.com/tr/pub/issue/45558/521927>
Chicago Özer, G , Adıgüzel, H , Katırcı Kırmacı, Z , Ergun, N . "Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease?". Journal of Surgery and Medicine 3 (2019 ): 437-440
RIS TY - JOUR T1 - Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease? AU - Gökhan Özer , Hatice Adıgüzel , Zekiye İpek Katırcı Kırmacı , Nevin Ergun Y1 - 2019 PY - 2019 N1 - doi: 10.28982/josam.521927 DO - 10.28982/josam.521927 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 437 EP - 440 VL - 3 IS - 6 SN - -2602-2079 M3 - doi: 10.28982/josam.521927 UR - https://doi.org/10.28982/josam.521927 Y2 - 2019 ER -
EndNote %0 Journal of Surgery and Medicine Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease? %A Gökhan Özer , Hatice Adıgüzel , Zekiye İpek Katırcı Kırmacı , Nevin Ergun %T Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease? %D 2019 %J Journal of Surgery and Medicine %P -2602-2079 %V 3 %N 6 %R doi: 10.28982/josam.521927 %U 10.28982/josam.521927
ISNAD Özer, Gökhan , Adıgüzel, Hatice , Katırcı Kırmacı, Zekiye İpek , Ergun, Nevin . "Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease?". Journal of Surgery and Medicine 3 / 6 (Haziran 2019): 437-440 . https://doi.org/10.28982/josam.521927
AMA Özer G , Adıgüzel H , Katırcı Kırmacı Z , Ergun N . Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease?. J Surg Med. 2019; 3(6): 437-440.
Vancouver Özer G , Adıgüzel H , Katırcı Kırmacı Z , Ergun N . Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease?. Journal of Surgery and Medicine. 2019; 3(6): 437-440.
IEEE G. Özer , H. Adıgüzel , Z. Katırcı Kırmacı ve N. Ergun , "Is insulin resistance associated with fatigue, the severity of the disease and motor disability in idiopathic Parkinson’s disease?", Journal of Surgery and Medicine, c. 3, sayı. 6, ss. 437-440, Haz. 2019, doi:10.28982/josam.521927