Research Article
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Nano-based ceramic surgical blade accelerates wound healing

Year 2021, Volume 5, Issue 9, 924 - 927, 01.09.2021
https://doi.org/10.28982/josam.857885

Abstract

Background/Aim: Many factors affect the results of a surgical operation, one of which is the harmony of the materials used during surgery with the tissue. Zirconia is a material with antimicrobial properties, high surface sensitivity and robustness. This study was conducted to observe the acute and subacute effects of the nano-based zirconia surgical blade on living tissue. Methods: The study was conducted after approval was granted by the Sivas Cumhuriyet University Animal Experiments Local Ethics Committee with the decision number 65202830-050.04.04-33. A total of 16 rats were used in the study. Eight were incised with classic steel surgical blade and eight, with nano-based zirconia surgical blade. A total of 4 incisions were performed to each rat and the incisions were closed with 3.0 polypropylene suture. Tissue samples were obtained from the incisions on day 0, 3, 7 and 21, and examined histologically. Results: The epidermis layer thickness on days 7 and 21 (P=0.030, P=0.025), the dermis layer thickness on days 3 and 7 (P=0.035, P=0.030), muscle layer thickness on days 7 and 21 (P=0.030, P=0.025) were significantly increased and inflammatory cells were significantly less on days 3, 7 and 21 (P=0.030, P=0.020, P=0.025) in the nano-ceramic surgical blade compared to the other group. Collagen tissue density was significantly higher in favor of the nano-ceramic blade on the 3rd and 7th days (P=0.025, P=0.020). Conclusion: Nano-based zirconia surgical blade has been shown to have positive effects on wound healing. The use of nano-based zirconia surgical blade should be kept in mind in patient groups with wound healing problems.

References

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  • 2. Mftah A, Alhassan FH, Al-Qubaisi MS, El Zowalaty ME, Webster TJ, Sh-eldin M, et al. Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles. International Journal of Nanomedicine. 2015;10: 765.
  • 3. Kuai JC, Zhang FH, Liu YZ. ELID Grinding Technology of Nano-Material Cutting Tool. In Applied Mechanics and Materials. 2012;155:960-4.
  • 4. Kuai JC, Zhang FH, Liu YZ. ELID Grinding Technology of Nano-Ceramic Scalpel. In Advanced Materials Research. 2012;468:1560-3.
  • 5. Strong AL, Bowles AC, MacCrimmon CP, Frazier TP, Lee SJ, Wu X, et al. Adipose stromal cells repair pressure ulcers in both young and elderly mice: potential role of adipogenesis in skin repair. Stem Cells Translational Medicine. 2015;4(6):632-42.
  • 6. Barbul A. Wound healing. Schwartz’s Principles of Surgery. Mc Graw Hill Eight edition. 2005;223.
  • 7. Sherris DA, Kern EB. The Wound. In Basic Surgical Skills, Mayo Foundation for medical Education and research, Rochester, 1999:8-12.
  • 8. Pakyari M, Farokhi A, Jalili RB, Kilani RT, Brown E, Ghahary, A. Local Expression of Indoleamine 2, 3, Dioxygenase Prolongs Allogenic Skin Graft Take in a Mouse Model. Advances in Wound Care. 2018;8(2):58-70.
  • 9. Özpolat B, Gürpınar Aylin Ö, Ayva Şebnem E, Gazyağcı S, Niyaz M. The effect of basic fibroblast growth factor and adipose tissue-derived mesenchymal stem cells on wound healing, epithelization and angiogenesis in a tracheal resection and end-to-end anastomosis rat model. Turkish Journal of Thoracic and Cardiovascular Surgery. 2013;21:1010-9.
  • 10. Gupta A, Kumar P. Assessment of the histological state of the healing wound. Plastic and Aesthetic Research. 2015;2(5):239.
  • 11. Durgun M, Durgun Ögücü S, Özakpınar Rıfat H, Eryılmaz Tolga A, Öktem Fatih H, İnözü E, et al. Approach to of infected sternotomy wounds in the management of mediastinitis. Turkish Journal of Thoracic and Cardiovascular Surgery. 2012;20:820-5.
  • 12. Ryu SW, Lee SH, Yoon HJ. A comparative histological and immunohistochemical study of wound healing following incision with a scalpel, CO2 laser or Er, Cr: YSGG laser in the Guinea pig oral mucosa. Acta Odontologica Scandinavica. 2012;70(6):448-54.
  • 13. Carreira LM, Azevedo P. Comparison of the Influence of CO2-laser and Scalpel Skin Incisions on the Surgical Wound Healing Process. ARC Journal of Anesthesiology. 2016;1(3):1-8.
  • 14. Jawad MM, Alam MK, AbdulQader ST, Al-Azzawi LM, Husein A, Mahmood AS. Histological evaluation of incision healing response made by metallic scalpel on rabbits skin: preliminary study. International Medical Journal. 2013;20(4):496-8.
  • 15. Demir T, Kara C, Özbek E, Kalkan Y. Evaluation of neodymium-doped yttrium aluminium garnet laser, scalpel incision wounds, and low-level laser therapy for wound healing in rabbit oral mucosa: a pilot study. Photomedicine and laser surgery. 2010;28(1):31-7.
  • 16. Tuncer I, Özçakır-Tomruk C, Şencift K, Çöloğlu S. Comparison of conventional surgery and CO2 laser on intraoral soft tissue pathologies and evaluation of the collateral thermal damage. Photomedicine and laser surgery. 2010;28(1):75-9.
  • 17. Kara C, Süleyman H, Tezel A, Orbak R, Cadirci E, Polat B, Kara I. Evaluation of pain levels after Nd: YAG laser and scalpel incisions: an experimental study in rats. Photomedicine and laser surgery. 2010;28(5):635-8.
  • 18. Pearce EC, Hall JE, Boyd KL, Rousseau B, Ries WR. The Ophthalmology Microscalpel versus Standard Scalpels and Wound Healing in a Rat Model. Otolaryngology-Head and Neck Surgery. 2014;151(3):424-30.
  • 19. Tsai PH, Lin YZ, Li JB, Jian SR, Jang JSC, Li C, et al. Sharpness improvement of surgical blade by means of ZrCuAlAgSi metallic glass and metallic glass thin film coating. Intermetallics. 2012;31:127-31.
  • 20. Kelley DB, Abt AB. Uniform Tissue Sections Cut with a Double-Bladed Scalpel. Journal of Histotechnology.2013;16(4):363-4.

Year 2021, Volume 5, Issue 9, 924 - 927, 01.09.2021
https://doi.org/10.28982/josam.857885

Abstract

References

  • 1. Parsak CK, Sakman G, Çelik, Ü. Yara iyileşmesi, yara bakımı ve komplikasyonları. Arşiv Kaynak Tarama Dergisi. 2007;16(2):145-59.
  • 2. Mftah A, Alhassan FH, Al-Qubaisi MS, El Zowalaty ME, Webster TJ, Sh-eldin M, et al. Physicochemical properties, cytotoxicity, and antimicrobial activity of sulphated zirconia nanoparticles. International Journal of Nanomedicine. 2015;10: 765.
  • 3. Kuai JC, Zhang FH, Liu YZ. ELID Grinding Technology of Nano-Material Cutting Tool. In Applied Mechanics and Materials. 2012;155:960-4.
  • 4. Kuai JC, Zhang FH, Liu YZ. ELID Grinding Technology of Nano-Ceramic Scalpel. In Advanced Materials Research. 2012;468:1560-3.
  • 5. Strong AL, Bowles AC, MacCrimmon CP, Frazier TP, Lee SJ, Wu X, et al. Adipose stromal cells repair pressure ulcers in both young and elderly mice: potential role of adipogenesis in skin repair. Stem Cells Translational Medicine. 2015;4(6):632-42.
  • 6. Barbul A. Wound healing. Schwartz’s Principles of Surgery. Mc Graw Hill Eight edition. 2005;223.
  • 7. Sherris DA, Kern EB. The Wound. In Basic Surgical Skills, Mayo Foundation for medical Education and research, Rochester, 1999:8-12.
  • 8. Pakyari M, Farokhi A, Jalili RB, Kilani RT, Brown E, Ghahary, A. Local Expression of Indoleamine 2, 3, Dioxygenase Prolongs Allogenic Skin Graft Take in a Mouse Model. Advances in Wound Care. 2018;8(2):58-70.
  • 9. Özpolat B, Gürpınar Aylin Ö, Ayva Şebnem E, Gazyağcı S, Niyaz M. The effect of basic fibroblast growth factor and adipose tissue-derived mesenchymal stem cells on wound healing, epithelization and angiogenesis in a tracheal resection and end-to-end anastomosis rat model. Turkish Journal of Thoracic and Cardiovascular Surgery. 2013;21:1010-9.
  • 10. Gupta A, Kumar P. Assessment of the histological state of the healing wound. Plastic and Aesthetic Research. 2015;2(5):239.
  • 11. Durgun M, Durgun Ögücü S, Özakpınar Rıfat H, Eryılmaz Tolga A, Öktem Fatih H, İnözü E, et al. Approach to of infected sternotomy wounds in the management of mediastinitis. Turkish Journal of Thoracic and Cardiovascular Surgery. 2012;20:820-5.
  • 12. Ryu SW, Lee SH, Yoon HJ. A comparative histological and immunohistochemical study of wound healing following incision with a scalpel, CO2 laser or Er, Cr: YSGG laser in the Guinea pig oral mucosa. Acta Odontologica Scandinavica. 2012;70(6):448-54.
  • 13. Carreira LM, Azevedo P. Comparison of the Influence of CO2-laser and Scalpel Skin Incisions on the Surgical Wound Healing Process. ARC Journal of Anesthesiology. 2016;1(3):1-8.
  • 14. Jawad MM, Alam MK, AbdulQader ST, Al-Azzawi LM, Husein A, Mahmood AS. Histological evaluation of incision healing response made by metallic scalpel on rabbits skin: preliminary study. International Medical Journal. 2013;20(4):496-8.
  • 15. Demir T, Kara C, Özbek E, Kalkan Y. Evaluation of neodymium-doped yttrium aluminium garnet laser, scalpel incision wounds, and low-level laser therapy for wound healing in rabbit oral mucosa: a pilot study. Photomedicine and laser surgery. 2010;28(1):31-7.
  • 16. Tuncer I, Özçakır-Tomruk C, Şencift K, Çöloğlu S. Comparison of conventional surgery and CO2 laser on intraoral soft tissue pathologies and evaluation of the collateral thermal damage. Photomedicine and laser surgery. 2010;28(1):75-9.
  • 17. Kara C, Süleyman H, Tezel A, Orbak R, Cadirci E, Polat B, Kara I. Evaluation of pain levels after Nd: YAG laser and scalpel incisions: an experimental study in rats. Photomedicine and laser surgery. 2010;28(5):635-8.
  • 18. Pearce EC, Hall JE, Boyd KL, Rousseau B, Ries WR. The Ophthalmology Microscalpel versus Standard Scalpels and Wound Healing in a Rat Model. Otolaryngology-Head and Neck Surgery. 2014;151(3):424-30.
  • 19. Tsai PH, Lin YZ, Li JB, Jian SR, Jang JSC, Li C, et al. Sharpness improvement of surgical blade by means of ZrCuAlAgSi metallic glass and metallic glass thin film coating. Intermetallics. 2012;31:127-31.
  • 20. Kelley DB, Abt AB. Uniform Tissue Sections Cut with a Double-Bladed Scalpel. Journal of Histotechnology.2013;16(4):363-4.

Details

Primary Language English
Subjects Surgery
Journal Section Research article
Authors

Fatih ADA (Primary Author)
SİVAS CUMHURİYET ÜNİVERSİTESİ
0000-0002-6953-5906
Türkiye


Erkan GÜMÜŞ
ADNAN MENDERES UNIVERSITY
0000-0001-6432-7457
Türkiye


Ferit KASIMZADE
Ankara Şehir Hastanesi
0000-0003-3646-3181
Türkiye

Publication Date September 1, 2021
Published in Issue Year 2021, Volume 5, Issue 9

Cite

Bibtex @research article { josam857885, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2021}, volume = {5}, pages = {924 - 927}, doi = {10.28982/josam.857885}, title = {Nano-based ceramic surgical blade accelerates wound healing}, key = {cite}, author = {Ada, Fatih and Gümüş, Erkan and Kasımzade, Ferit} }
APA Ada, F. , Gümüş, E. & Kasımzade, F. (2021). Nano-based ceramic surgical blade accelerates wound healing . Journal of Surgery and Medicine , 5 (9) , 924-927 . DOI: 10.28982/josam.857885
MLA Ada, F. , Gümüş, E. , Kasımzade, F. "Nano-based ceramic surgical blade accelerates wound healing" . Journal of Surgery and Medicine 5 (2021 ): 924-927 <http://jsurgmed.com/en/pub/issue/64812/857885>
Chicago Ada, F. , Gümüş, E. , Kasımzade, F. "Nano-based ceramic surgical blade accelerates wound healing". Journal of Surgery and Medicine 5 (2021 ): 924-927
RIS TY - JOUR T1 - Nano-based ceramic surgical blade accelerates wound healing AU - Fatih Ada , Erkan Gümüş , Ferit Kasımzade Y1 - 2021 PY - 2021 N1 - doi: 10.28982/josam.857885 DO - 10.28982/josam.857885 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 924 EP - 927 VL - 5 IS - 9 SN - -2602-2079 M3 - doi: 10.28982/josam.857885 UR - https://doi.org/10.28982/josam.857885 Y2 - 2021 ER -
EndNote %0 Journal of Surgery and Medicine Nano-based ceramic surgical blade accelerates wound healing %A Fatih Ada , Erkan Gümüş , Ferit Kasımzade %T Nano-based ceramic surgical blade accelerates wound healing %D 2021 %J Journal of Surgery and Medicine %P -2602-2079 %V 5 %N 9 %R doi: 10.28982/josam.857885 %U 10.28982/josam.857885
ISNAD Ada, Fatih , Gümüş, Erkan , Kasımzade, Ferit . "Nano-based ceramic surgical blade accelerates wound healing". Journal of Surgery and Medicine 5 / 9 (September 2021): 924-927 . https://doi.org/10.28982/josam.857885
AMA Ada F. , Gümüş E. , Kasımzade F. Nano-based ceramic surgical blade accelerates wound healing. J Surg Med. 2021; 5(9): 924-927.
Vancouver Ada F. , Gümüş E. , Kasımzade F. Nano-based ceramic surgical blade accelerates wound healing. Journal of Surgery and Medicine. 2021; 5(9): 924-927.
IEEE F. Ada , E. Gümüş and F. Kasımzade , "Nano-based ceramic surgical blade accelerates wound healing", Journal of Surgery and Medicine, vol. 5, no. 9, pp. 924-927, Sep. 2021, doi:10.28982/josam.857885

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