Year 2020, Volume 4 , Issue 11, Pages 1013 - 1017 2020-11-01

Ülseratif kolit için potansiyel erken yaşam risk faktörlerinin değerlendirilmesi
Evaluation of potential early life risk factors for ulcerative colitis

Yasemin GÖKDEN [1] , Deniz OGUTMEN KOC [2]


Amaç: Erken yaşam faktörlerinin bağırsak mikrobiyomunu etkileyerek iltihaplı bağırsak hastalığı riskini etkileyebileceği öne sürülmüştür. Doğum şekli, anne sütü ve ebeveynlerin sigara içmesi en önemli çevresel faktörlerdir. Bu faktörlerin hastalığın yeri ve tanı anındaki yaş üzerindeki etkileri konusunda sınırlı sayıda çalışma bulunmaktadır. Ayrıca bu faktörlerin medikal tedavilere ve barsak tutulum yerine etkisi de bilinmemektedir. Yaşamın ilk yıllarında yaşanan potansiyel erken yaşam risk faktörleri ile ülseratif kolit (ÜK) arasındaki ilişkiyi inceledik. Yöntemler: Bu çalışma prospektif bir vaka kontrol çalışmasıdır. Atmış dokuz ÜK hastası yaş ve cinsiyet bakımından benzer 44 sağlıklı kontrol ile karşılaştırıldı. Potansiyel erken yaşam risk faktörü olabilecek doğum şekli, anne sütü ile beslenme, anne doğum yaşı, anne ve baba sigara kullanım durumları araştırıldı. ÜK hastalarında bu potansiyel faktörlerin hastalık tanı yaşı, medikal tedavilerle ilişkisi incelendi. Bulgular: ÜK ve kontrol grubu, doğum şekilleri, anne sütü ile beslenme, anne-baba sigara kullanma durumları bakımından karşılaştırıldığında gruplar arasında istatistiksel farklılık izlenmedi. Anne sütü alma süreleri bakımından karşılaştırıldığında ise 6-12 ay arası anne sütü alanlar, ÜK grubunda daha düşük saptanmıştır (P=0,046). Ayrıca anne sütü almayan ÜK hastaları ile annesi sigara kullanan ÜK hastalarının hastalık tanı yaşları daha düşük bulunmuştur (sırasıyla: P=0,031, P=0,016). Sonuçlar: ÜK gelişimi açısından emzirmenin süresi önemlidir. ÜK’den korunmak için 6 aydan daha uzun anne sütü ile beslenme önermekteyiz. Erken başlangıçlı ÜK riski açısından annenin sigarayı bırakmasının koruyucu rolü vardır.
Aim: It has been suggested that early life factors may affect the risk of inflammatory bowel disease by affecting the gut microbiome. Delivery type, breast milk, and parental smoking are the most important environmental factors. There are limited studies on the effects of these factors on the location of the disease and age at diagnosis. In addition, the effects of these factors on medical treatments and bowel involvement are unknown. We examined the relationship between potential early-life risk factors experienced in the first years of life and ulcerative colitis (UC). Material and Method: This study is a prospective case-control study. Sixty-nine UC patients were compared with 44 age- and sex-matched healthy controls (HC). We investigated delivery type, breastfeeding, maternal age at birth, and parents' smoking status, which may be potential early-life risk factors. Our analysis involved the relationship of these potential factors with the age at diagnosis and medical treatments in UC patients. Results: UC and HC groups were compared in terms of delivery type, breastfeeding, and parents' smoking status: There was no statistical difference between the groups. In terms of the duration of breastfeeding, we found that 6-12 months of breastfeeding was lower in the UC group (P=0.046). In addition, the age at diagnosis of the disease was lower in UC patients who were not breastfed and whose mothers smoked (P=0.031, P=0.016, respectively). Conclusions: The duration of breastfeeding is important for the development of UC. We recommend breastfeeding for longer than six months to prevent UC. Maternal smoking cessation has a protective role in the risk of early-onset UC.
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Primary Language en
Subjects Gastroenterology and Hepatology
Journal Section Research article
Authors

Orcid: 0000-0001-6767-3072
Author: Yasemin GÖKDEN (Primary Author)
Institution: University of Health Sciences Cemil Tascıoglu City Hospital, Department of Gastroenterology Istanbul, Turkey,
Country: Turkey


Orcid: 0000-0003-2738-625X
Author: Deniz OGUTMEN KOC
Institution: University of Health Sciences Gaziosmanpasa Training and Research Hospital, Department of Gastroenterology, Istanbul, Turkey
Country: Turkey


Dates

Publication Date : November 1, 2020

Bibtex @research article { josam826501, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {1013 - 1017}, doi = {10.28982/josam.826501}, title = {Evaluation of potential early life risk factors for ulcerative colitis}, key = {cite}, author = {Gökden, Yasemin and Ogutmen Koc, Deniz} }
APA Gökden, Y , Ogutmen Koc, D . (2020). Evaluation of potential early life risk factors for ulcerative colitis . Journal of Surgery and Medicine , 4 (11) , 1013-1017 . DOI: 10.28982/josam.826501
MLA Gökden, Y , Ogutmen Koc, D . "Evaluation of potential early life risk factors for ulcerative colitis" . Journal of Surgery and Medicine 4 (2020 ): 1013-1017 <http://jsurgmed.com/en/pub/issue/57748/826501>
Chicago Gökden, Y , Ogutmen Koc, D . "Evaluation of potential early life risk factors for ulcerative colitis". Journal of Surgery and Medicine 4 (2020 ): 1013-1017
RIS TY - JOUR T1 - Evaluation of potential early life risk factors for ulcerative colitis AU - Yasemin Gökden , Deniz Ogutmen Koc Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.826501 DO - 10.28982/josam.826501 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 1013 EP - 1017 VL - 4 IS - 11 SN - -2602-2079 M3 - doi: 10.28982/josam.826501 UR - https://doi.org/10.28982/josam.826501 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Evaluation of potential early life risk factors for ulcerative colitis %A Yasemin Gökden , Deniz Ogutmen Koc %T Evaluation of potential early life risk factors for ulcerative colitis %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 11 %R doi: 10.28982/josam.826501 %U 10.28982/josam.826501
ISNAD Gökden, Yasemin , Ogutmen Koc, Deniz . "Evaluation of potential early life risk factors for ulcerative colitis". Journal of Surgery and Medicine 4 / 11 (November 2020): 1013-1017 . https://doi.org/10.28982/josam.826501
AMA Gökden Y , Ogutmen Koc D . Evaluation of potential early life risk factors for ulcerative colitis. J Surg Med. 2020; 4(11): 1013-1017.
Vancouver Gökden Y , Ogutmen Koc D . Evaluation of potential early life risk factors for ulcerative colitis. Journal of Surgery and Medicine. 2020; 4(11): 1013-1017.
IEEE Y. Gökden and D. Ogutmen Koc , "Evaluation of potential early life risk factors for ulcerative colitis", Journal of Surgery and Medicine, vol. 4, no. 11, pp. 1013-1017, Nov. 2020, doi:10.28982/josam.826501