Year 2020, Volume 4 , Issue 11, Pages 1073 - 1076 2020-11-01

Neoadjuvan kemoterapi alan mide kanseri hastalarında surviye etkili prognostik faktörler: Türkiye’den kesitsel bir çalışma
Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey

Orhan UZUN [1] , Selçuk GÜLMEZ [2] , Aziz Serkan SENGER [3] , Ayhan ÖZ [4] , Ömer ÖZDUMAN [5] , Cem Batuhan OFLUOĞLU [6] , Erdal POLAT [7] , Mustafa DUMAN [8]


Amaç: Mide kanseri ileri evrede karşımıza çıkar ve kansere bağlı ölümler arasında en üst sıralarda yer almaktadır. Overall sürviyi uzatmak için neoadjuvan kemoterapi alan mide kanseri hastalarında surviye etkili prognostik faktörleri araştırmayı amaçladık. Yöntemler: Kasım 2006 - Eylül 2019 tarihleri arasında mide kanseri nedeniyle ameliyat edilen hastalar retrospektif olarak incelendi. Neoadjuvan kemoterapi alan 46 hasta ile neoadjuvan kemoterapi almayan 194 hasta klinikopatolojik özelliklerine değerlendirildi. Neoadjuvan kemoterapi alan hastaların surviye etki eden prognostik faktörleri Cox regresyon analizi ile değerlendirildi. Bulgular: Neoadjuvan kemoterapi alan hastalar tüm hastaların %19.2’sini oluşturmaktaydı. Bu hastaların tümör yerleşim yeri genellikle üst ve orta yerleşimliydi (%73,9) ve istatistiksel bir farklılık mevcuttu (P=0,001). İki grup arasında sürvi bakımından istatistiksel bir farklılık yoktu. Ancak neoadjuvan kemoterapi alan hastaların pozitif lenf nodu sayısının fazla olması surviye etkili en önemli prognostik faktör olarak bulundu (P<0,01). Sonuç: Neoadjuvan kemoterapi sonrası pozitif lenf nodu sayısının yüksek olması sürvi bakımından en önemli prognostik faktör olup, cerrahi sonrası kemoterapi protokolü değiştirilebilinir veya kemoterapi ile beraber başka yöntemler uygulanabilinir.
Aim: Gastric cancer is usually diagnosed once it has reached the advanced stage and is one of the leading causes of cancer-related deaths. We investigated the prognostic factors for survival among gastric cancer patients undergoing neoadjuvant chemotherapy to prolong overall survival. Methods: A retrospective review was made of patients who underwent surgery for gastric cancer between November 2006 and September 2019. Clinicopathological characteristics were assessed in 46 patients receiving neoadjuvant chemotherapy and 194 patients not receiving neoadjuvant therapy. A Cox regression analysis was used to assess the prognostic factors for survival among the patients receiving neoadjuvant chemotherapy. Results: The patients receiving neoadjuvant chemotherapy accounted for 19.2% of the total. The tumors in these patients were located primarily in the upper and middle portions (73.9%), to a statistically significant degree (P=0.001). There was no statistical difference in survival between the two groups, although a high number of positive lymph nodes was identified among the patients receiving neoadjuvant chemotherapy as the most significant prognostic factor for survival (P<0.01). Conclusion: After neoadjuvant chemotherapy, multiple positive lymph nodes are the most important prognostic factor for survival; postoperative chemotherapy protocol can be changed or other methods can be applied together with chemotherapy.
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Primary Language en
Subjects Surgery, Gastroenterology and Hepatology, Oncology
Journal Section Research article
Authors

Orcid: 0000-0001-6550-0936
Author: Orhan UZUN (Primary Author)
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KARTAL KOŞUYOLU YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey


Orcid: 0000-0001-9719-1904
Author: Selçuk GÜLMEZ
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KARTAL KOŞUYOLU YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey


Orcid: 0000-0003-0981-0141
Author: Aziz Serkan SENGER
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KARTAL KOŞUYOLU YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey


Orcid: 0000-0003-1383-3573
Author: Ayhan ÖZ
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KARTAL KOŞUYOLU YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey


Orcid: 0000-0002-6527-506X
Author: Ömer ÖZDUMAN
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KARTAL KOŞUYOLU YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey


Orcid: 0000-0002-0670-8590
Author: Cem Batuhan OFLUOĞLU
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KARTAL KOŞUYOLU YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey


Orcid: 0000-0002-9463-9846
Author: Erdal POLAT
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KARTAL KOŞUYOLU YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey


Orcid: 0000-0002-0276-0543
Author: Mustafa DUMAN
Institution: SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, İSTANBUL KARTAL KOŞUYOLU YÜKSEK İHTİSAS SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ
Country: Turkey


Dates

Publication Date : November 1, 2020

Bibtex @research article { josam816374, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {1073 - 1076}, doi = {10.28982/josam.816374}, title = {Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey}, key = {cite}, author = {Uzun, Orhan and Gülmez, Selçuk and Senger, Aziz Serkan and Öz, Ayhan and Özduman, Ömer and Ofluoğlu, Cem Batuhan and Polat, Erdal and Duman, Mustafa} }
APA Uzun, O , Gülmez, S , Senger, A , Öz, A , Özduman, Ö , Ofluoğlu, C , Polat, E , Duman, M . (2020). Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey . Journal of Surgery and Medicine , 4 (11) , 1073-1076 . DOI: 10.28982/josam.816374
MLA Uzun, O , Gülmez, S , Senger, A , Öz, A , Özduman, Ö , Ofluoğlu, C , Polat, E , Duman, M . "Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey" . Journal of Surgery and Medicine 4 (2020 ): 1073-1076 <http://jsurgmed.com/en/pub/issue/57748/816374>
Chicago Uzun, O , Gülmez, S , Senger, A , Öz, A , Özduman, Ö , Ofluoğlu, C , Polat, E , Duman, M . "Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey". Journal of Surgery and Medicine 4 (2020 ): 1073-1076
RIS TY - JOUR T1 - Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey AU - Orhan Uzun , Selçuk Gülmez , Aziz Serkan Senger , Ayhan Öz , Ömer Özduman , Cem Batuhan Ofluoğlu , Erdal Polat , Mustafa Duman Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.816374 DO - 10.28982/josam.816374 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 1073 EP - 1076 VL - 4 IS - 11 SN - -2602-2079 M3 - doi: 10.28982/josam.816374 UR - https://doi.org/10.28982/josam.816374 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey %A Orhan Uzun , Selçuk Gülmez , Aziz Serkan Senger , Ayhan Öz , Ömer Özduman , Cem Batuhan Ofluoğlu , Erdal Polat , Mustafa Duman %T Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 11 %R doi: 10.28982/josam.816374 %U 10.28982/josam.816374
ISNAD Uzun, Orhan , Gülmez, Selçuk , Senger, Aziz Serkan , Öz, Ayhan , Özduman, Ömer , Ofluoğlu, Cem Batuhan , Polat, Erdal , Duman, Mustafa . "Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey". Journal of Surgery and Medicine 4 / 11 (November 2020): 1073-1076 . https://doi.org/10.28982/josam.816374
AMA Uzun O , Gülmez S , Senger A , Öz A , Özduman Ö , Ofluoğlu C , Polat E , Duman M . Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey. J Surg Med. 2020; 4(11): 1073-1076.
Vancouver Uzun O , Gülmez S , Senger A , Öz A , Özduman Ö , Ofluoğlu C , Polat E , Duman M . Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey. Journal of Surgery and Medicine. 2020; 4(11): 1073-1076.
IEEE O. Uzun , S. Gülmez , A. Senger , A. Öz , Ö. Özduman , C. Ofluoğlu , E. Polat and M. Duman , "Prognostic factors for survival among gastric cancer patients receiving neoadjuvant chemotherapy: A cross sectional study from Turkey", Journal of Surgery and Medicine, vol. 4, no. 11, pp. 1073-1076, Nov. 2020, doi:10.28982/josam.816374