Year 2020, Volume 4 , Issue 11, Pages 1077 - 1081 2020-11-01

A novel approach in the diagnosis and follow-up of sarcoidosis
Sarkoidozun tanı ve takibinde yeni bir yaklaşım

Aydın BALCI [1] , Suphi AYDIN [2]


Aim: Sarcoidosis is characterized by the presence of non-caseous granulomas that can involve all organs, especially the lungs and mediastinal lymph nodes. No biomarker investigated in recent years appears to be specific for sarcoidosis. We aimed to investigate and evaluate the relationship between neutrophil-lymphocyte ratios (NLR), platelet-lymphocyte ratios (PLR), monocyte-lymphocyte ratios (MLR), eosinophil-lymphocyte ratios (ELR), and blood count parameters in sarcoidosis patients. Methods: A total of 150 individuals comprising 97 sarcoidosis patients, and 53 controls, were included in the study. The data were recorded retrospectively. Chest X-ray findings were analyzed with regards to age, gender, body mass index, modified medical research concept (MMRC) dyspnea scale and respiratory function parameters. Blood count, NLR, PLR, MLR, eosinophil/basophil ratio (EBR) were evaluated in patients with sarcoidosis. Results: Hemoglobin (g/dl) and lymphocyte count (103 /UL) values were significantly lower in sarcoidosis patients, while red blood cell distribution width standard deviation (RDW SD) (fl), neutrophil count (103 /UL), monocyte count (103 /UL), basophil count (103 /UL), NLR, PLR, MLR values were significantly higher compared to the control group. However, platelet (103 /UL), MPV and EBR values were similar. Conclusion: Our study showed that MLR value, which was not previously used in sarcoidosis patients, is an important biomarker in the diagnosis of sarcoidosis, just as NLR.
Amaç: Sarkoidoz, akciğerler ve mediastinal lenf nodları başta olmak üzere tüm organları tutabilen non-kazeifiye granülomların varlığı ile karakterize bir hastalıktır. Yıllardır yapılan araştırmalarda sarkoidoz için spesifik bir biyobelirteç gösterilememiştir. Çalışmamızda, sarkoidoz hastalarında nötrofil-lenfosit oranları (NLO), trombosit-lenfosit oranları (PLR), monosit-lenfosit oranları (MLR), eozinofil-lenfosit oranları (ELR), kan sayım parametreleri arasındaki ilişkiyi araştırmayı ve çıkan sonuçları değerlendirmeyi amaçladık. Yöntem: Çalışmaya 97 sarkoidoz hastası, 53 kontrol olmak üzere toplam 150 kişi dahil edildi. Veriler geriye dönük olarak kaydedildi. Göğüs röntgeni bulguları yaş, cinsiyet, vücut kitle indeksi, modifiye tıbbi araştırma kavramı (Mmrc) dispne ölçeği ve solunum fonksiyon parametreleri dikkate alınarak analiz edildi. Sarkoidozlu hastalarda kan sayımı, NLR, PLR, MLR, eozinofil / bazofil oranı (EBR) değerlendirildi. Bulgular: Sarkoidoz hastaları ile kontrol grubunun laboratuvar değerleri karşılaştırıldığında, sarkoidoz hastalarında hemoglobin (g/dl) değeri ve lenfosit sayısı (103 /UL) değerleri, kontrol grubuna göre anlamlı olarak düşük bulundu. Aksine, kırmızı kan hücresi dağılım genişliği standart sapması (RDW SD) (fl), nötrofil sayısı (103 /UL), monosit sayısı (103 /UL), bazofil sayısı (103 /UL), NLR, PLR, MLR değeri sarkoidoz hastalarınında kontrol grubuna göre anlamlı derecede yüksek bulundu. Trombosit (103 /UL), MPV ve EBR değerleri karşılaştırıldığında ise anlamlı bir fark gözlenmedi. Sonuç: Bu çalışma bize, sarkoidoz hastalarında daha önce kullanılmayan MLR değerinin NLR değeri gibi sarkoidoz tanısında kullanılabilecek önemli bir biyobelirteç olabileceğini göstermiştir.
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Primary Language en
Subjects Surgery
Journal Section Research article
Authors

Orcid: 0000-0002-6723-2418
Author: Aydın BALCI
Institution: TIP FAKÜLTESİ
Country: Turkey


Orcid: 0000-0003-2102-0484
Author: Suphi AYDIN (Primary Author)
Institution: Afyonkarahisar Sağlık Bilimleri Üniversitesi
Country: Turkey


Dates

Publication Date : November 1, 2020

Bibtex @research article { josam811687, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {1077 - 1081}, doi = {10.28982/josam.811687}, title = {A novel approach in the diagnosis and follow-up of sarcoidosis}, key = {cite}, author = {Balcı, Aydın and Aydın, Suphi} }
APA Balcı, A , Aydın, S . (2020). A novel approach in the diagnosis and follow-up of sarcoidosis . Journal of Surgery and Medicine , 4 (11) , 1077-1081 . DOI: 10.28982/josam.811687
MLA Balcı, A , Aydın, S . "A novel approach in the diagnosis and follow-up of sarcoidosis" . Journal of Surgery and Medicine 4 (2020 ): 1077-1081 <http://jsurgmed.com/en/pub/issue/57748/811687>
Chicago Balcı, A , Aydın, S . "A novel approach in the diagnosis and follow-up of sarcoidosis". Journal of Surgery and Medicine 4 (2020 ): 1077-1081
RIS TY - JOUR T1 - A novel approach in the diagnosis and follow-up of sarcoidosis AU - Aydın Balcı , Suphi Aydın Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.811687 DO - 10.28982/josam.811687 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 1077 EP - 1081 VL - 4 IS - 11 SN - -2602-2079 M3 - doi: 10.28982/josam.811687 UR - https://doi.org/10.28982/josam.811687 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine A novel approach in the diagnosis and follow-up of sarcoidosis %A Aydın Balcı , Suphi Aydın %T A novel approach in the diagnosis and follow-up of sarcoidosis %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 11 %R doi: 10.28982/josam.811687 %U 10.28982/josam.811687
ISNAD Balcı, Aydın , Aydın, Suphi . "A novel approach in the diagnosis and follow-up of sarcoidosis". Journal of Surgery and Medicine 4 / 11 (November 2020): 1077-1081 . https://doi.org/10.28982/josam.811687
AMA Balcı A , Aydın S . A novel approach in the diagnosis and follow-up of sarcoidosis. J Surg Med. 2020; 4(11): 1077-1081.
Vancouver Balcı A , Aydın S . A novel approach in the diagnosis and follow-up of sarcoidosis. Journal of Surgery and Medicine. 2020; 4(11): 1077-1081.
IEEE A. Balcı and S. Aydın , "A novel approach in the diagnosis and follow-up of sarcoidosis", Journal of Surgery and Medicine, vol. 4, no. 11, pp. 1077-1081, Nov. 2020, doi:10.28982/josam.811687