Year 2020, Volume 4 , Issue 11, Pages 974 - 977 2020-11-01

Multiple skleroz hastalarında C-reaktif protein/albümin oranı ve hastalık alt tipi ve disabilite ile ilişkisi
C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability

Fettah EREN [1] , Aysegul DEMİR [2]


Amaç: Oksidatif stres ve inflamasyon Multiple Skleroz (MS) hastalarında demiyelinizasyon ve aksonal hasarın sebebidir. Serum C-reaktif protein (CRP) ve albümin düzeyleri birçok hastalıkta sistemik inflamasyon ve oksidatif stresin belirteci olarak kullanılmaktadır. Bu çalışmada, MS hastalığında CRP/albümin düzeyinin saptanması, hastalık alt tipi ve dizabilite ile ilişkisini değerlendirilmesi amaçlanmıştır. Yöntemler: Bu kesitsel çalışma MS hastalığı nedeniyle tedavi edilen hastalarda yapıldı. Çalışmaya 120 MS hastası ve 62 sağlıklı kontrol alındı. Sosyodemografik özellikler sorgulandı. MS subtipi belirlendi. Dizabilite genişletilmiş özürlülük durum ölçeği (EDSS) ile hesaplandı. Hastalar EDSS 0-3 (hafif), 3,5-4,5 (orta) ve 5,0 veya üzeri (ağır) olmak üzere 3 gruba ayrıldı. Atak sıklığı belirlendi. Albümin ve CRP serum seviyesi belirlendi. Hemogram floresans akış sitometrisi ile ölçüldü. Bulgular: Çalışmada 71 (%59,2) kadın ve 49 (%40,8) erkek hasta vardı. Yaş ortalamaları 39,49 (11,47) idi. MS hastalarında lökosit değeri daha yüksek, albümin ise düşüktü (P=0,046; 0,006). Progresif MS hastalarında relapsing remitting alt tipine göre CRP ve CRP/albümin oranı daha yüksek, albümin seviyesi daha düşüktü (P<0,01). EDSS yüksek olan hastalarda CRP ve CRP/albümin oranı daha yüksek, albümin seviyesi daha düşüktü (P<0,01). Atak sayısı ile CRP/albümin oranı arasında zayıf korelasyon saptandı (P=0,032; r=0,196). Sonuç: Bu çalışmada albümin seviyesi ve CRP/albümin oranının MS hastalığında hastalık alt tipi ve aktivitesi ile ilişkili olduğu ortaya konulmuştur.
Aim: Oxidative stress and inflammation are the cause of demyelination and axonal damage in patients with Multiple Sclerosis (MS). Serum C-reactive protein (CRP) and albumin levels are used as a marker of systemic inflammation and oxidative stress for many diseases. In this study, we aimed to determine the level of CRP/albumin ratio in patients with MS and its relationship with disease subtype and disability. Methods: This cross-sectional study was conducted in patients treated for MS disease. One hundred twenty MS patients and 62 healthy controls were included. Sociodemographic characteristics were questioned. MS subtype was determined. Disability was calculated with Expanded Disability Status Scale (EDSS). Patients were divided into 3 groups: EDSS 0-3 (minor), 3.5-4.5 (moderate) and 5.0 or higher (major). Attack frequency, albumin and CRP serum levels were noted, and hemogram was analyzed with fluorescence flow cytometry. Results: There were 71 (59.2%) female and 49 (40.8%) male patients in the study, and their mean age was 39.49 (11.47) years. Leukocyte value was higher and albumin was lower in patients with MS (P=0.046, P=0.006). In progressive MS patients, CRP and CRP/albumin ratio was higher and albumin level was lower compared to the relapse remitting subtype (P<0.01). Patients with high EDSS had higher CRP and CRP/albumin ratio and lower albumin levels (P<0.01). A low correlation was detected between the number of attacks and CRP/albumin ratio (P=0.032; r=0.196). Conclusion: We detected that albumin level and CRP/albumin ratio are related with subtype and activity of MS disease.
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Primary Language en
Subjects Clinical Neurology
Journal Section Research article
Authors

Orcid: 0000-0001-6834-0827
Author: Fettah EREN (Primary Author)
Institution: Sağlık Bilimleri Üniversitesi, Konya Eğitim ve Araştırma Hastanesi, Nöroloji Kliniği, Konya
Country: Turkey


Orcid: 0000-0002-5444-9837
Author: Aysegul DEMİR
Institution: University of Health Sciences Turkey, Konya Training and Research Hospital, Clinic of Neurology, Konya, Turkey
Country: Turkey


Supporting Institution The authors declared that this study received no financial support
Thanks The author would like to thank; Dr Güllü Eren, Necmettin Erbakan University, Meram Faculty of Medicine, Department of Public Health and Dr Recep Aygül, Selcuk University, Faculty of Medicine, Department of Neurology.
Dates

Publication Date : November 1, 2020

Bibtex @research article { josam736846, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {974 - 977}, doi = {10.28982/josam.736846}, title = {C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability}, key = {cite}, author = {Eren, Fettah and Demi̇r, Aysegul} }
APA Eren, F , Demi̇r, A . (2020). C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability . Journal of Surgery and Medicine , 4 (11) , 974-977 . DOI: 10.28982/josam.736846
MLA Eren, F , Demi̇r, A . "C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability" . Journal of Surgery and Medicine 4 (2020 ): 974-977 <http://jsurgmed.com/en/pub/issue/57748/736846>
Chicago Eren, F , Demi̇r, A . "C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability". Journal of Surgery and Medicine 4 (2020 ): 974-977
RIS TY - JOUR T1 - C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability AU - Fettah Eren , Aysegul Demi̇r Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.736846 DO - 10.28982/josam.736846 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 974 EP - 977 VL - 4 IS - 11 SN - -2602-2079 M3 - doi: 10.28982/josam.736846 UR - https://doi.org/10.28982/josam.736846 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability %A Fettah Eren , Aysegul Demi̇r %T C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 11 %R doi: 10.28982/josam.736846 %U 10.28982/josam.736846
ISNAD Eren, Fettah , Demi̇r, Aysegul . "C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability". Journal of Surgery and Medicine 4 / 11 (November 2020): 974-977 . https://doi.org/10.28982/josam.736846
AMA Eren F , Demi̇r A . C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability. J Surg Med. 2020; 4(11): 974-977.
Vancouver Eren F , Demi̇r A . C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability. Journal of Surgery and Medicine. 2020; 4(11): 974-977.
IEEE F. Eren and A. Demi̇r , "C-reactive protein/albumin ratio in patients with multiple sclerosis and its relationship with disease subtype and disability", Journal of Surgery and Medicine, vol. 4, no. 11, pp. 974-977, Nov. 2020, doi:10.28982/josam.736846