Year 2020, Volume 4 , Issue 9, Pages 812 - 816 2020-09-01

Erken nötrofil/eozinofil oranı ile nötrofil ve beyaz kan hücrelerinin seviyeleri spontan intraserebral hemorajili hastalarda hastane içi mortaliteyi öngörüyor mu?
Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages?

Ersin ÖZEREN [1] , Muzaffer GÜNEŞ [2]


Amaç: Son yıllarda, spontan intraserebral hemorajide (ICH) kırmızı kan hücresi dağılım genişliği (RDW), nötrofil/lenfosit oranı (NLO) ve C-reaktif protein/albümin oranı (CAO) gibi inflamatuar belirteçler araştırılmıştır. Ancak, bunlar ICH’de birlikte incelenmemiştir. Bu çalışmada, spontan ICH tanısı alan hastalarda başvuru sırasında yukarıda belirtilen belirteçlerle birlikte nötrofil, nötrofil/eozinofil oranı (NEO) ve beyaz kan hücresi (WBC) düzeylerinin hastane içi mortaliteyi tahmin edip etmediğini araştırdık. Yöntemler: Bu retrospektif kohort çalışmasını, Nisan 2015 - Mart 2019 tarihleri arasında kliniğimizde yatan spontan ICH hastalarını inceleyerek gerçekleştirdik. Hastaları hayatta kalanlar ve hayatta kalmayanlar olarak iki gruba ayırdık. Mortalite için laboratuvar değişkenlerinin prediktif değerini değerlendirmek ve kesme değerlerini hesaplamak için, alıcı çalışma karakteristikleri (ROC) eğrisi analizi kullanılmıştır. Bulgular: Çalışmaya, 82’si hayatta kalan ve 48’i hayatta kalmayan olmak üzere 130 hasta dahil edildi. Hastanede ölen hastaların medyan hemoraji hacmi, WBC ve nötrofil değerleri yaşayanlara göre anlamlı olarak yüksekti (sırasıyla P<0,001; P=0,001 ve P=0,003). Medyan CAO, NLO, NEO ve RDW-SD değerleri açısından iki grup arasında fark yoktu (sırasıyla P=0,216; P=0,237; P=0,229 ve P=0,215). ROC eğrisi altındaki alan: WBC için 0,676 (% 95 CI; 0,57-0,78) ve nötrofil için 0,659 (% 95 CI; 0,56-0,76) idi. Sonuç: Sonuçlarımız, spontan ICH'nin akut evresinde daha yüksek nötrofil ve WBC düzeyleri hastaların hastane içi mortalitesini öngörmüştür. NEO’nın predikdif değeri için ileri çalışmalara ihtiyaç vardır.
Aim: In recent years, inflammatory markers such as red blood cell distribution width (RDW), neutrophil to lymphocyte ratio (NLR), and C-reactive protein to albumin ratio (CAR) have been investigated in spontaneous intracerebral hemorrhage (ICH). However, they were not analyzed together in ICH. In the present study, we examined whether neutrophil, neutrophil to eosinophil ratio (NER), and white blood cell (WBC) levels along with the above-mentioned markers predict the intrahospital mortality in patients diagnosed with spontaneous ICH at admission. Methods: We conducted this retrospective cohort study by examining spontaneous ICH patients hospitalized in our clinic between April 2015 and March 2019. We divided patients into two groups, as survivors and non-survivors. The receiver operating characteristics (ROC) curve analysis test was used to evaluate the predictive value of laboratory variables for mortality and to calculate cut-off values. Results: A total of 130 patients, 82 survivors and 48 non-survivors, were included in the study. The patients who were non-survivors at the hospital had significantly higher median hemorrhage volume, WBC, and neutrophil levels compared to those of survivors (P<0.001, P=0.001 and P=0.003, respectively). There was no significant difference between the two groups in terms of median CAR, NLR, NER, and RDW-SD values (P=0.216, P=0.237, P=0.229, and P=0.215, respectively). The area under the ROC curve was 0.676 (95% CI, 0.57-0.78) for WBC and 0.659 (95% CI, 0.56-0.76) for neutrophil. Conclusion: Our results showed that the elevated neutrophil and WBC levels at the acute phase of spontaneous ICH predict the intrahospital mortality of the patients. Further studies are required for the predictive value of NER.
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Primary Language en
Subjects Clinical Neurology
Journal Section Research article
Authors

Orcid: 0000-0001-9861-274X
Author: Ersin ÖZEREN
Institution: Aksaray University Faculty of Medicine
Country: Turkey


Orcid: 0000-0002-9325-1292
Author: Muzaffer GÜNEŞ (Primary Author)
Institution: Aksaray University Faculty of Medicine
Country: Turkey


Dates

Publication Date : September 1, 2020

Bibtex @research article { josam780127, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {812 - 816}, doi = {10.28982/josam.780127}, title = {Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages?}, key = {cite}, author = {Özeren, Ersin and Güneş, Muzaffer} }
APA Özeren, E , Güneş, M . (2020). Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages? . Journal of Surgery and Medicine , 4 (9) , 812-816 . DOI: 10.28982/josam.780127
MLA Özeren, E , Güneş, M . "Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages?" . Journal of Surgery and Medicine 4 (2020 ): 812-816 <http://jsurgmed.com/en/pub/issue/56766/780127>
Chicago Özeren, E , Güneş, M . "Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages?". Journal of Surgery and Medicine 4 (2020 ): 812-816
RIS TY - JOUR T1 - Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages? AU - Ersin Özeren , Muzaffer Güneş Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.780127 DO - 10.28982/josam.780127 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 812 EP - 816 VL - 4 IS - 9 SN - -2602-2079 M3 - doi: 10.28982/josam.780127 UR - https://doi.org/10.28982/josam.780127 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages? %A Ersin Özeren , Muzaffer Güneş %T Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages? %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 9 %R doi: 10.28982/josam.780127 %U 10.28982/josam.780127
ISNAD Özeren, Ersin , Güneş, Muzaffer . "Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages?". Journal of Surgery and Medicine 4 / 9 (September 2020): 812-816 . https://doi.org/10.28982/josam.780127
AMA Özeren E , Güneş M . Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages?. J Surg Med. 2020; 4(9): 812-816.
Vancouver Özeren E , Güneş M . Do early neutrophil to eosinophil ratio and the levels of neutrophil and white blood cells predict intra-hospital mortality in patients with spontaneous intracerebral hemorrhages?. Journal of Surgery and Medicine. 2020; 4(9): 812-816.