Year 2020, Volume 4 , Issue 9, Pages 733 - 737 2020-09-01

Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates
IVF adaylarında AMH ve FSH seviyelerine göre oosit sayısının tahmini

Nur DOKUZEYLÜL GÜNGÖR [1] , Tuğba GÜRBÜZ [2]


Aim: The purpose of this study was to predict the number of oocytes using anti-Mullerian hormone (AMH) and Follicle Stimulating Hormone (FSH) levels in In Vitro Fertilization (IVF) candidates. Methods: This retrospective cohort study included 121 (23 cases with poor response, 92 cases with normal response, and 6 cases with excessive response) infertile patients. We examined the relationship between AMH and FSH levels and the number of oocytes. The method used in this study was to consider the number of oocytes as the response variable and identify the effective factors. All analyses were performed with free R software. Results: The results show that although the ovarian response is associated with serum AMH levels and the women's age (P=0.04 and P<0.001, respectively), the negative linear and binomial regression yield a significant collinearity and the natural logarithm of AMH alone can be a good estimate of the ovarian response (P<0.001). ROC curves in logistic regression were used to determine cutoff points. The results of this regression showed that the natural logarithm of AMH with a cutoff value of 1.36 ng/ml can determine the line between the poor and normal ovarian response (P<0.01). The natural logarithm of AMH cannot determine the cutoff value of normal and excessive ovarian response (P>0.05). Conclusion: The use of serum AMH levels is important for the prediction of poor ovarian response.
Amaç: Bu çalışmanın amacı IVF tedavisi planlanan olgularda serum AMH ve FSH düzeylerini kullanarak oosit sayısını tahmin etmektir. Yöntemler: Bu retrospektif kohort çalışma 121 infertil hastayı (düşük over rezervi (n=23), normal over rezervi (n=92) ve yüksek over rezervi (n=6)) kapsamaktadır. Çalışmada AMH, FSH ve oosit sayıları arasındaki ilişki değerlendirilmiştir. Oosit sayısı değişken yanıt olarak kabul edilip etkileyen faktörler tanımlanmıştır. Tüm analizler ücretsiz R software ile yapılmıştır. Bulgular: Sonuçlar, over cevabının serum AMH seviyeleri ve ayrıca kadınların yaşı (sırasıyla P=0,04 ve P<0,001) ile ilişkili olmasına rağmen, negatif doğrusal ve binom regresyonunun, anlamlı bir eşdoğrusallık ve tek başına AMH'nin doğal logaritmasının olduğunu gösterdiğini göstermektedir ve over cevabı için iyi bir tahmini olabilir (P<0,001). Kesim noktalarını belirlemek için lojistik regresyondaki ROC eğrileri kullanılmıştır. Bu regresyonun sonuçları, 1,36 ng/ml'lik bir kesme değerine sahip doğal AMH logaritmasının, zayıf ve normal yumurtalık tepkisi arasındaki sınırı belirleyebileceğini gösterdi (P<0,01). AMH'nin doğal logaritması, normal ve aşırı over cevabının kesim değerini belirleyemez (P>0,05). Sonuç: AMH özellikle düşük over rezervinin tahmininde predikte edici önemli bir faktördür.
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Primary Language en
Subjects Obstetrics and Gynecology
Journal Section Research article
Authors

Orcid: 0000-0002-7234-3876
Author: Nur DOKUZEYLÜL GÜNGÖR
Institution: Bahçeşehir Üniversitesi Göztepe Medikal Park Hastanesi
Country: Turkey


Orcid: 0000-0003-3555-3767
Author: Tuğba GÜRBÜZ (Primary Author)
Institution: Özel Medistate Hastanesi Kadın Hastalıkları ve Doğum Kliniği , İstanbul ,Türkiye
Country: Turkey


Supporting Institution yok
Dates

Publication Date : September 1, 2020

Bibtex @research article { josam759207, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {733 - 737}, doi = {10.28982/josam.759207}, title = {Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates}, key = {cite}, author = {Dokuzeylül Güngör, Nur and Gürbüz, Tuğba} }
APA Dokuzeylül Güngör, N , Gürbüz, T . (2020). Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates . Journal of Surgery and Medicine , 4 (9) , 733-737 . DOI: 10.28982/josam.759207
MLA Dokuzeylül Güngör, N , Gürbüz, T . "Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates" . Journal of Surgery and Medicine 4 (2020 ): 733-737 <http://jsurgmed.com/en/pub/issue/56766/759207>
Chicago Dokuzeylül Güngör, N , Gürbüz, T . "Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates". Journal of Surgery and Medicine 4 (2020 ): 733-737
RIS TY - JOUR T1 - Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates AU - Nur Dokuzeylül Güngör , Tuğba Gürbüz Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.759207 DO - 10.28982/josam.759207 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 733 EP - 737 VL - 4 IS - 9 SN - -2602-2079 M3 - doi: 10.28982/josam.759207 UR - https://doi.org/10.28982/josam.759207 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates %A Nur Dokuzeylül Güngör , Tuğba Gürbüz %T Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 9 %R doi: 10.28982/josam.759207 %U 10.28982/josam.759207
ISNAD Dokuzeylül Güngör, Nur , Gürbüz, Tuğba . "Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates". Journal of Surgery and Medicine 4 / 9 (September 2020): 733-737 . https://doi.org/10.28982/josam.759207
AMA Dokuzeylül Güngör N , Gürbüz T . Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates. J Surg Med. 2020; 4(9): 733-737.
Vancouver Dokuzeylül Güngör N , Gürbüz T . Prediction of the number of oocytes based on AMH and FSH levels in IVF candidates. Journal of Surgery and Medicine. 2020; 4(9): 733-737.