Year 2020, Volume 4 , Issue 1, Pages 38 - 42 2020-01-02

Klinik örneklerden izole edilen beta-hemolitik streptokok suşları, özellikleri ve antibiyotik duyarlılığı
Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility

Çiğdem ARABACI [1] , Kenan AK [2]


Amaç: Beta Hemolitik Streptococcus (BHS) türleri, idrar yolu enfeksiyonu, cilt/yumuşak doku enfeksiyonları, tonsillofarenjit gibi üst solunum yolu enfeksiyonları, yenidoğanda menenjit, sepsis ve pnömoni gibi birçok enfeksiyonda rol oynar. Bu çalışmanın amacı klinik örneklerden izole edilen BHS türlerini, enfeksiyon özelliklerini ve antibiyotik duyarlılık profillerini belirlemektir.

Yöntemler: Laboratuvarımızda Ocak 2014 - Haziran 2019 tarihleri arasında, 1110 (%87) ayaktan ve 166 (%13) yatarak tedavi gören hastadan izole edilen 1276 beta hemolitik streptokok (BHS) suşu, özellikleri ve 320 suşun antimikrobiyal duyarlılığı retrospektif olarak incelendi. Çalışmanın tipi kesitsel çalışmadır. 

Bulgular: Toplam 1276 BHS izolatının; %48,6 grup B, %33,9 grup A, %9,6 grup F, %5,7 grup C ve %2,2 grup G BHS idi. İncelenen BHS enfeksiyonlarının; %42,9'u idrar yolu enfeksiyonu, %34,6'sı tonsillit/tonsillofarenjit, %15,7'si cilt/yumuşak doku enfeksiyonu, %3' ü kan dolaşımı enfeksiyonu ve %1'i menenjit, pnömoni, konjonktivit ve peritonit idi. %2,8 Grup B Streptokok izolatı vajinal kolonizasyon olarak kabul edildi. Hastaların %11,2'sinde birden fazla altta yatan hastalık vardı. Tüm izolatlar penisilin, vankomisin, linezolid ve tigesikline duyarlıydı. Eritromisin, klindamisin ve tetrasiklin direnci Grup A Streptokok ve Grup B Streptokok için sırasıyla %5, %2, %40 ve %34, %11, %90 olarak belirlendi.

Sonuç: Erken tanı ve uygun antibiyoterapi streptokok enfeksiyonlarının tedavisinde önemli parametrelerdir. Beta-hemolitik streptokoklarda penisilin direnci olmasa da, klinik başarısızlıkların varlığı, özellikle Grup B Streptokok 'da penisilin Minimal İnhibitör Konsantrasyonu (MİK) değerlerinin artışı, makrolid ve florokinolon direncinin artması nedeniyle antibiyotik duyarlılığının yakından izlenmesi gerektiğini düşünüyoruz.

Aim: Beta Hemolytic Streptococcus (BHS) species play a role in many infections, such as urinary tract infection, skin/soft tissue infections, neonatal meningitis, sepsis, pneumonia as well as upper respiratory tract infections like tonsillopharyngitis. The aim of this study was to determine the types of BHS species, their infectious characteristics and antibiotic susceptibility profiles in clinical specimens. 

Methods: In this cross-sectional study, infectious features of 1276 streptococcus strains isolated from 1110 (87%) outpatients and 166 (13%) inpatients between January 2014 and June 2019 at our laboratory and antimicrobial susceptibility of the 320 strains were analyzed retrospectively. 

Results: Retrospective analysis of 1276 BHS isolates revealed that 48.6% were group B, 33.9% were group A, 9.6% were group F, 5.7% were group C and 2.2% were group G BHS. Among isolated BHS infections, 42.9% caused urinary tract infection, 34.6% caused tonsillitis/tonsillopharyngitis, 15.7% were isolated from skin/soft tissue infections, 3% were found in the bloodstream, and 1% in meningitis, pneumonia, conjunctivitis, and peritonitis. About 2.8% Group B Streptococcus were considered vaginal colonization. Among all patients, 11.2% had more than one underlying disease. All isolates were susceptible to penicillin, vancomycin, linezolid and tigecycline. Erythromycin, clindamycin, and tetracycline resistance rates were determined as 5%, 2%, 40% respectively for Group A and 34%, 11%, 90%, respectively for Group B Streptococcus.

Conclusion: Early diagnosis and appropriate antibiotherapy are important parameters in the management of streptococcal infections. Although there is no penicillin resistance in beta-hemolytic streptococci, we think that antibiotic susceptibility should be closely monitored due to increasing clinical failures, penicillin Minimal inhibitory concentration (MIC) values, and macrolide and fluoroquinolone resistance, especially in Group B Streptococcus.

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Primary Language en
Subjects Microbiology
Journal Section Research article
Authors

Orcid: 0000-0003-0050-3225
Author: Çiğdem ARABACI (Primary Author)
Institution: Department of Medical Microbiology Laboratory, Okmeydani Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Country: Turkey


Orcid: 0000-0001-5863-3685
Author: Kenan AK
Institution: Department of Medical Microbiology Laboratory, Okmeydani Training and Research Hospital, University of Health Sciences, Istanbul, Turkey.
Country: Turkey


Supporting Institution Yok
Thanks Yok
Dates

Publication Date : January 2, 2020

Bibtex @research article { josam672119, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {38 - 42}, doi = {10.28982/josam.672119}, title = {Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility}, key = {cite}, author = {Arabacı, Çiğdem and Ak, Kenan} }
APA Arabacı, Ç , Ak, K . (2020). Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility . Journal of Surgery and Medicine , 4 (1) , 38-42 . DOI: 10.28982/josam.672119
MLA Arabacı, Ç , Ak, K . "Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility" . Journal of Surgery and Medicine 4 (2020 ): 38-42 <http://jsurgmed.com/en/pub/issue/51597/672119>
Chicago Arabacı, Ç , Ak, K . "Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility". Journal of Surgery and Medicine 4 (2020 ): 38-42
RIS TY - JOUR T1 - Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility AU - Çiğdem Arabacı , Kenan Ak Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.672119 DO - 10.28982/josam.672119 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 38 EP - 42 VL - 4 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.672119 UR - https://doi.org/10.28982/josam.672119 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility %A Çiğdem Arabacı , Kenan Ak %T Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 1 %R doi: 10.28982/josam.672119 %U 10.28982/josam.672119
ISNAD Arabacı, Çiğdem , Ak, Kenan . "Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility". Journal of Surgery and Medicine 4 / 1 (January 2020): 38-42 . https://doi.org/10.28982/josam.672119
AMA Arabacı Ç , Ak K . Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility. J Surg Med. 2020; 4(1): 38-42.
Vancouver Arabacı Ç , Ak K . Beta hemolytic Streptococci strains isolated from clinical specimens, their characteristics and antibiotic susceptibility. Journal of Surgery and Medicine. 2020; 4(1): 38-42.