Year 2020, Volume 4 , Issue 1, Pages 89 - 92 2020-01-02

İnflamatuvar belirteçlerin periprostetik enfeksiyonların belirlenmesinde rolü var mıdır?
Do inflammatory markers play a role in the detection of periprosthetic infections?

Duran TOPAK [1] , Ahmet SALAN [2] , Fatih DOĞAR [3] , Selçuk NAZİK [4]


Amaç: Total kalça veya diz artroplastisi sonrası periprostetik eklem enfeksiyonu en korkulan komplikasyonlardan biridir. Bu çalışmanın amacı, inflamatuvar biyobelirteçlerin periprostetik eklem enfeksiyonunun tanımlanmasındaki etkinliğini değerlendirmektir.

Yöntemler: Çalışma kesitsel ve iki merkezli planlandı. Protez enfeksiyonundan şüphelenilen ve üç fazlı kemik sintigrafisi uygulanan 131 hasta dahil edildi. Hastalar Kas İskelet Enfeksiyonları Derneği kriterlerine ve sintigrafik çalışma sonuçlarına göre üç gruba ayrıldı: Grup 1 protez enfeksiyonu olan olgular, Grup 2 aseptik gevşemesi olan olgular, Grup 3 sağlıklı protezleri olan olgulardan oluşmaktadır.

Bulgular: Beyaz küre sayısı ortalaması grup 1'de 11,5 (3,2) 109/L, grup 2'de 8,3 (2,1) 109/L ve grup 3'de 7,9 (2,1) 109/L bulundu. Beyaz küre sayısı değerleri grup 1'de diğer gruplara göre istatistiksel olarak anlamlı derecede yüksek bulundu (P<0,001, P<0,001), grup 2 ve 3 arasında anlamlı fark yoktu (P=0,753). C reactive protein değerleri grup 1'de 46,6 (50,0) mg/L, grup 2'de 18,8 (17,5) mg/L ve grup 3'de 15,3 (17,1) mg/L olarak bulundu ve C reactive protein değerleri gruplar arasında karşılaştırıldığında istatistiksel olarak anlamlı derecede yüksek bulundu. Grup 1'de diğer gruplara göre (P<0,001, P<0,001) ve grup 2 ile 3 arasında anlamlı fark yoktu (P=0,876). Ortalama eritrosit sedimantasyon hızı değerleri karşılaştırıldığında gruplar arasında anlamlı fark bulunmadı.

Sonuç Üç fazlı kemik sintigrafisi, C reactive protein ve beyaz küre sayısı gibi inflamatuvar biyobelirteçlerin kullanılmasının, protez enfeksiyonunu öngörümede etkili olduğu gösterilmiştir.

Aim: Periprosthetic joint infection after total hip or knee arthroplasty is one of the most feared complications. The aim of this study was to evaluate the efficacy of inflammatory biomarkers in identifying periprosthetic joint infection.

Methods: This cross-sectional and bi-centered study included 131 patients, who had suspected prosthesis infection and underwent three-phase bone scintigraphy. Patients were divided into three groups according to the Musculoskeletal Infection Society criteria and scintigraphic study results: Group 1 comprised cases with prosthetic infection, Group 2 included aseptic loosening cases and Group 3 included cases with healthy prostheses.

Results: White blood cell average was 11.5 (3.2) 109/L in group 1, 8. (2.1) 109/L in group 2 and 7.9 (2.1) 109/L in group 3, among which it was significantly higher in Group 1 compared to Groups 2 and 3, (P<0.001, P<0.001), while there was no significant difference between groups 2 and 3 (P=0.753). C reactive protein values (CRP) were 46.6 (50.0) mg/L in group 1, 18.8 (17.5) mg/L in group 2 and 15.3 (17.1) mg/L in group 3, significantly higher in group 1 than the other groups (P<0.001, P<0.001), and similar in Groups 2 and 3 (P=0.876). The mean erythrocyte sedimentation rate values did not differ significantly between the groups. 

Conclusion: The use of three-phase bone scintigraphy and inflammatory biomarkers such as C reactive protein and white blood cell have been shown to be effective in predicting prosthetic infection.

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Primary Language en
Subjects Surgery
Journal Section Research article
Authors

Orcid: 0000-0002-1442-3392
Author: Duran TOPAK (Primary Author)
Institution: Kahramanmaraş sütçü imam Ünv tıp fakültesi
Country: Turkey


Orcid: 0000-0002-5022-1851
Author: Ahmet SALAN
Institution: KAHRAMANMARAŞ HEALTH ACADEMY
Country: Turkey


Orcid: 0000-0003-3848-1017
Author: Fatih DOĞAR
Institution: KAHRAMANMARAŞ HEALTH ACADEMY
Country: Turkey


Orcid: 0000-0003-0587-0104
Author: Selçuk NAZİK
Institution: KAHRAMANMARAŞ HEALTH ACADEMY
Country: Turkey


Supporting Institution yok
Project Number yok
Thanks yok
Dates

Publication Date : January 2, 2020

Bibtex @research article { josam671101, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {89 - 92}, doi = {10.28982/josam.671101}, title = {Do inflammatory markers play a role in the detection of periprosthetic infections?}, key = {cite}, author = {Topak, Duran and Salan, Ahmet and Doğar, Fatih and Nazi̇k, Selçuk} }
APA Topak, D , Salan, A , Doğar, F , Nazi̇k, S . (2020). Do inflammatory markers play a role in the detection of periprosthetic infections? . Journal of Surgery and Medicine , 4 (1) , 89-92 . DOI: 10.28982/josam.671101
MLA Topak, D , Salan, A , Doğar, F , Nazi̇k, S . "Do inflammatory markers play a role in the detection of periprosthetic infections?" . Journal of Surgery and Medicine 4 (2020 ): 89-92 <http://jsurgmed.com/en/pub/issue/51597/671101>
Chicago Topak, D , Salan, A , Doğar, F , Nazi̇k, S . "Do inflammatory markers play a role in the detection of periprosthetic infections?". Journal of Surgery and Medicine 4 (2020 ): 89-92
RIS TY - JOUR T1 - Do inflammatory markers play a role in the detection of periprosthetic infections? AU - Duran Topak , Ahmet Salan , Fatih Doğar , Selçuk Nazi̇k Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.671101 DO - 10.28982/josam.671101 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 89 EP - 92 VL - 4 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.671101 UR - https://doi.org/10.28982/josam.671101 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine Do inflammatory markers play a role in the detection of periprosthetic infections? %A Duran Topak , Ahmet Salan , Fatih Doğar , Selçuk Nazi̇k %T Do inflammatory markers play a role in the detection of periprosthetic infections? %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 1 %R doi: 10.28982/josam.671101 %U 10.28982/josam.671101
ISNAD Topak, Duran , Salan, Ahmet , Doğar, Fatih , Nazi̇k, Selçuk . "Do inflammatory markers play a role in the detection of periprosthetic infections?". Journal of Surgery and Medicine 4 / 1 (January 2020): 89-92 . https://doi.org/10.28982/josam.671101
AMA Topak D , Salan A , Doğar F , Nazi̇k S . Do inflammatory markers play a role in the detection of periprosthetic infections?. J Surg Med. 2020; 4(1): 89-92.
Vancouver Topak D , Salan A , Doğar F , Nazi̇k S . Do inflammatory markers play a role in the detection of periprosthetic infections?. Journal of Surgery and Medicine. 2020; 4(1): 89-92.