Year 2020, Volume 4 , Issue 1, Pages 43 - 47 2020-01-02

Annelerdeki vitamin B12 ve folat düzeylerinin, yenidoğanlardaki vitamin B12 ve folat düzeyleri, antropometrik ölçümler ve metabolik belirteçlerle ilişkisi
The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators

Emel ÜNSÜR [1] , Burçin KINAŞ [2] , Fatma KUTLUSOY [3] , Ülkü AKSOY [4] , Kıvanç ŞAHİN [5] , Tolga ÜNSÜR [6] , Huseyin AKSOY [7] , Nilgün TEKKEŞİN [8]


Amaç: Gebelikteki besin dengesizlikleri yenidoğanın gelecek yaşamında obeziteye neden olan metabolik problemlere yol açabilir. Çalışmamızda, gebeliğin sonunda annelerdeki folik asit, B12 vitamini düzeylerini belirlemek, yenidoğanın antropometrik ölçümleri, serum lipit profili, insülin direnci gibi metabolik göstergeleri arasındaki ilişkiyi araştırmak amaçlandı.

Yöntemler: Toplam 102 anne ve bebek prospektif kohort çalışmaya dahil edildi. Demografik, obstetrik özellikler, serum B12 vitamini, folat, glikoz, yüksek yoğunluklu lipoprotein (HDL), düşük yoğunluklu lipoprotein (LDL), trigliseritler, kolesterol, insülin, homosistein ve homeostatik model değerlendirmesi (HOMA-IR ) not edildi. B12 vitamini için, ≥191 ng/L seviyeleri normal olarak kabul edildi. Maternal vitamin B12 ve folat seviyeleri ile yenidoğanların metabolik göstergeleri, antropometrik ölçümleri arasındaki ilişki araştırıldı.

Bulgular: Serum vitamin B12 düzeyi düşük olan annelerden doğan bebeklerde vücut kitle indeksi (P=0,004), serum insülin düzeyleri (P=0,012), HOMA-IR (P=0,001) ve homosistein (P=0,001) düzeyleri artmış olarak saptandı. Maternal B12 vitamini düzeylerinin, yenidoğan B12 vitamini düzeyleri ile kuvvetli korelasyon (r=0,719, P<0,001); serum insülin (r=-0,221, P=0,025), HOMA-IR (r=-0,249, P=0,011), homosistein (r=-0,394, P<0,001) seviyeleri arasında ters zayıf bir korelasyon saptandı. Maternal folat düzeyleri neonatal folat düzeyleri ile kuvvetli pozitif (r=0,735, P<0,001); yenidoğan B12 vitamini düzeyleri ile zayıf pozitif (r=0,327, P=0,001); neonatal homosistein seviyeleri ile orta derecede ters korelasyon gösterdi (r=-0,505, P<0,001).

Sonuç: Gebelik döneminde annelerde vitamin değerlerinin optimal seviyelerde tutulması, bebeklerin gelecek yaşamlarında obeziteye yol açabilecek metabolik dengesizliklerini azaltmak açısından önemlidir.

Aim: The nutritional imbalances in pregnancy may lead to metabolic problems in newborns, which may cause obesity during childhood and later in life. It is aimed to determine the maternal levels of folate, vitamin B12 at birth and to investigate the correlation between neonatal anthropometric measurements, and metabolic indicators such as serum lipid profile and insulin resistance.

Methods: A total of 102 mothers and newborns were enrolled in this prospective cohort study. The demographic, obstetric features, serum levels of vitamin B12, folate, glucose, high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, cholesterol, insulin, homocysteine, and homeostatic model assessment (HOMA-IR) were noted. For vitamin B12, levels, ≥191 ng/L were accepted as normal. The correlation between maternal levels of vitamin B12, folate, anthropometric measurements, and metabolic indicators of newborns were evaluated. 

Results: Body mass index (P=0.004), serum insulin levels (P=0.012), HOMA-IR (P=0.001), and homocysteine (P=0.001) were increased in neonates born from mothers with lower serum levels of vitamin B12. The maternal vitamin B12 levels were positively, strongly correlated with neonatal vitamin B12 levels (r=0.719, P<0.001). There was an inverse, weak correlation between maternal vitamin B12 levels and neonatal serum insulin levels (r=-0.221, P=0.025), HOMA-IR (r=-0.249, P=0.011), and homocysteine (r=-0.394, P<0.001). Maternal folate levels were strongly, positively correlated with neonatal folate (r=0.735, P<0.001); weakly, positively correlated with neonatal vitamin B12 (r=0.327, P=0.001); moderately, inversely correlated with neonatal homocysteine (r=-0.505, P<0.001).

Conclusion: Optimizing intake of these vitamins levels during pregnancy is important to reduce the neonatal metabolic abnormalities, which may lead to obesity later in life.

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Primary Language en
Subjects Pediatrics
Journal Section Research article
Authors

Orcid: 0000-0002-5816-7554
Author: Emel ÜNSÜR (Primary Author)
Institution: ACIBADEM UNIVERSITY
Country: Turkey


Orcid: 0000-0002-5816-7554
Author: Burçin KINAŞ
Institution: KAYSERİ MEMORIAL HOSPITAL
Country: Turkey


Orcid: 0000-0001-7008-4973
Author: Fatma KUTLUSOY
Institution: Department of Obstetrics and Gynaecology, Acıbadem Hospital, Kayseri, Turkey
Country: Turkey


Orcid: 0000-0003-1010-9248
Author: Ülkü AKSOY
Institution: Department of Obstetrics and Gynaecology Memorial Hospital, Kayseri, Turkey
Country: Turkey


Orcid: 0000-0002-9402-5887
Author: Kıvanç ŞAHİN
Institution: Department of Obstetrics and Gynaecology, Erkilet Maternity and Children Hospital, Kayseri, Turkey
Country: Turkey


Orcid: 0000-0001-6032-462X
Author: Tolga ÜNSÜR
Institution: Department of Pediatrics, Erkilet Maternity and Children Hospital, Kayseri, Turkey
Country: Turkey


Orcid: 0000-0003-3467-3783
Author: Huseyin AKSOY
Institution: Department of Obstetrics and Gynaecology, Kayseri City Hospital, Kayseri, Turkey
Country: Turkey


Orcid: 0000-0001-8115-9643
Author: Nilgün TEKKEŞİN
Institution: Department of Biochemistry, Memorial Hospital, Istanbul, Turkey
Country: Turkey


Supporting Institution -
Thanks DR FATMA KUTLUSOY,DR KIVANÇ ŞAHİN,DR ÜLKÜ AKSOY
Dates

Publication Date : January 2, 2020

Bibtex @research article { josam669066, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2020}, volume = {4}, pages = {43 - 47}, doi = {10.28982/josam.669066}, title = {The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators}, key = {cite}, author = {Ünsür, Emel and Kınaş, Burçin and Kutlusoy, Fatma and Aksoy, Ülkü and Şahi̇n, Kıvanç and Ünsür, Tolga and Aksoy, Huseyin and Tekkeşi̇n, Nilgün} }
APA Ünsür, E , Kınaş, B , Kutlusoy, F , Aksoy, Ü , Şahi̇n, K , Ünsür, T , Aksoy, H , Tekkeşi̇n, N . (2020). The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators . Journal of Surgery and Medicine , 4 (1) , 43-47 . DOI: 10.28982/josam.669066
MLA Ünsür, E , Kınaş, B , Kutlusoy, F , Aksoy, Ü , Şahi̇n, K , Ünsür, T , Aksoy, H , Tekkeşi̇n, N . "The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators" . Journal of Surgery and Medicine 4 (2020 ): 43-47 <http://jsurgmed.com/en/pub/issue/51597/669066>
Chicago Ünsür, E , Kınaş, B , Kutlusoy, F , Aksoy, Ü , Şahi̇n, K , Ünsür, T , Aksoy, H , Tekkeşi̇n, N . "The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators". Journal of Surgery and Medicine 4 (2020 ): 43-47
RIS TY - JOUR T1 - The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators AU - Emel Ünsür , Burçin Kınaş , Fatma Kutlusoy , Ülkü Aksoy , Kıvanç Şahi̇n , Tolga Ünsür , Huseyin Aksoy , Nilgün Tekkeşi̇n Y1 - 2020 PY - 2020 N1 - doi: 10.28982/josam.669066 DO - 10.28982/josam.669066 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 43 EP - 47 VL - 4 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.669066 UR - https://doi.org/10.28982/josam.669066 Y2 - 2020 ER -
EndNote %0 Journal of Surgery and Medicine The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators %A Emel Ünsür , Burçin Kınaş , Fatma Kutlusoy , Ülkü Aksoy , Kıvanç Şahi̇n , Tolga Ünsür , Huseyin Aksoy , Nilgün Tekkeşi̇n %T The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators %D 2020 %J Journal of Surgery and Medicine %P -2602-2079 %V 4 %N 1 %R doi: 10.28982/josam.669066 %U 10.28982/josam.669066
ISNAD Ünsür, Emel , Kınaş, Burçin , Kutlusoy, Fatma , Aksoy, Ülkü , Şahi̇n, Kıvanç , Ünsür, Tolga , Aksoy, Huseyin , Tekkeşi̇n, Nilgün . "The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators". Journal of Surgery and Medicine 4 / 1 (January 2020): 43-47 . https://doi.org/10.28982/josam.669066
AMA Ünsür E , Kınaş B , Kutlusoy F , Aksoy Ü , Şahi̇n K , Ünsür T , Aksoy H , Tekkeşi̇n N . The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators. J Surg Med. 2020; 4(1): 43-47.
Vancouver Ünsür E , Kınaş B , Kutlusoy F , Aksoy Ü , Şahi̇n K , Ünsür T , Aksoy H , Tekkeşi̇n N . The relationship between maternal and neonatal vitamin B12 and folate levels, anthropometric measurements, and metabolic indicators. Journal of Surgery and Medicine. 2020; 4(1): 43-47.