Year 2017, Volume 1 , Issue 1, Pages 1 - 4 2017-04-22

Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study
Bozulmuş Açlık Glukozu ve Bozulmuş Glukoz Toleransının Diyabet Gelişim Riski Üzerine Etkilerinin HbA1c Düzeyleri Üzerinden Karşılaştırılması: Bir Retrospektif Çalışma

Abdülkadir AYDIN [1] , Yıldız ATADAĞ [2] , Ahmet ÖKSÜZ [3] , Didem KAYA [4] , Nagehan Esra AYDIN [5]


Aim: The process between normal glucose metabolism and diabetes is called the prediabetic period. This period is impaired fasting glucose (IFG), impaired glucose tolerance (IGT) or glycosylated hemoglobin A1c (HbA1c) level of 5.7% -6.5%. IFG, IGT or IFG+IGT, shows increased risk of developing diabetes. The aim of this study is to compare the risk levels of diabetes development between glucose metabolism disorders.

Methods: Patients who underwent oral glucose tolerance test (OGTT) and whose HbA1c values ​​were measured before and after the test on a quarterly basis and did not have diabetes in 2016, were scanned through the automation system and taken into study. Patients with HbA1c levels between 5.7 and 6.4% were evaluated as prediabetic and an increase in the HbA1c levels in these patients from 5.7% to 6.4% was considered to increase the risk of developing diabetes. Patients were divided into three groups according to the presence of isolated IFG, isolated IGT and IFG + IGT. Patients with IFG were group 1, patients with IGT were group 2, and patients with IFG + IGT were group 3. Correlation analysis was performed between the groups on HbA1c levels.

Analyzes were performed using the SPSS 22.0 program. Mann Whitney U Test was used for descriptive statistical methods as well as for non-normal distribution of measured values. Significance was evaluated at p <0.05.

Results: In the study period, 706 patients who had OGTT in our hospital and who had HbA1c levels before and after OGTT on a quarterly basis were determined. The number of patients in Group 1 was 272; in group 2 was 222 and in group 3 was 212. Compared to the HbaA1c levels of groups, the risk of diabetes development in Group 1 was statistically low compared to group 2 and 3 (p<0,001). No statistically significant differences were detected between group 2 and 3 (p=0,381).

Conclusions: As a result of our study, patients with isolated IGT and IFG+IGT were found to be significantly higher than patients with an isolated IFG of diabetes development risks. There was no apparent difference between those with an isolated IGT and the IFG+IGT.

Amaç: Normal glukoz metabolizması ile aşikar diyabet arasındaki süreç prediyabetik dönem olarak adlandırılır. Bu dönem bozulmuş açlık glukozu (BAG), bozulmuş glukoz toleransı (BGT) veya glikozillenmiş hemoglobin A1c (HbA1c) düzeyinin %5,7-%6,5 olmasıdır. BAG, BGT veya BAG+BGT artmış diyabet gelişim riskini gösterir. Bu calışmanın amacı glukoz metabolizması bozukluklarının diyabet gelişim risk düzeylerini karşılaştırmaktır.

Yöntemler: 2016 yılı içinde oral glukoz tolerans testi (OGTT) yapılan, test öncesi ve sonrası üç aylık dönemde HbA1c değerleri ölçülen ve diyabet tanısı almamış hastalar, otomasyon sistemi üzerinden tarandı ve çalışmaya alındı. HbA1c düzeyi %5,7-6,4 arasında olan hastalar prediyabetik olarak değerlendirildi ve bu hastaların kendi içinde HbA1c düzeylerinin %5,7’den %6,4’e doğru artışı diyabet gelişim riskinde de artış kabul edildi. Çalışma hastaları izole BAG, izole BGT ve BAG+BGT varlığına göre üç gruba ayrıldı. İzole BAG saptanan hastalar grup 1’i, izole BGT saptanan hastalar grup 2’yi ve BAG+BGT saptanan hastalar grup 3’ü oluşturdu. Gruplar arasında HbA1c düzeyleri üzerinden korelasyon analizi yapıldı.

Çalışmada elde edilen bulgular değerlendirilirken istatistiksel analizler için SPSS 22.0 programı kullanıldı. Çalışma verileri değerlendirilirken tanımlayıcı istatistiksel metodların yanı sıra ölçüm değerlerinin normal dağılım göstermeyen karşılaştırmalarında Mann Whitney U Test kullanıldı. Anlamlılık p<0,05 düzeylerinde değerlendirildi.

Bulgular: Çalışma döneminde hastanemizde OGTT yapılan ve OGTT öncesi ve sonrası üç aylık dönemde HbA1c düzeyleri bakılan 706 hasta tespit edildi. Grup 1’deki hasta sayısı 272; grup 2’deki hasta sayısı 222, grup 3’deki hasta sayısı 212 olarak saptandı.  Grupların HbaA1c düzeyleri karşılaştırıldığında Grup 1’de diyabet gelişim riskinin grup 2 ve 3’e göre istatistiksel olarak anlamlı düzeyde düşük olduğu görüldü (p<0,001). Grup 2 ve 3 arasında istatistiksel olarak anlamlı bir farklılık saptanmadı (p=0,381).

Sonuç: Çalışmamız sonucunda izole BGT’si ve BAG+BGT’si olan hastaların diyabet gelişim riskleri izole BAG’si olan hastalara göre anlamlı oranda yüksek bulunmuştur. İzole BGT’si olanlarla BAG+BGT’si olanlar arasında ise belirgin bir farklılık saptanmamıştır.

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Subjects General and Internal Medicine
Journal Section Research article
Authors

Author: Abdülkadir AYDIN
Country: Turkey


Author: Yıldız ATADAĞ

Author: Ahmet ÖKSÜZ

Author: Didem KAYA

Author: Nagehan Esra AYDIN

Dates

Publication Date : April 22, 2017

Bibtex @research article { josam337791, journal = {Journal of Surgery and Medicine}, issn = {}, eissn = {2602-2079}, address = {jsurgmed@gmail.com}, publisher = {Fatih BAŞAK}, year = {2017}, volume = {1}, pages = {1 - 4}, doi = {10.28982/josam.337791}, title = {Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study}, key = {cite}, author = {Aydın, Abdülkadir and Atadağ, Yıldız and Öksüz, Ahmet and Kaya, Didem and Aydın, Nagehan Esra} }
APA Aydın, A , Atadağ, Y , Öksüz, A , Kaya, D , Aydın, N . (2017). Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study . Journal of Surgery and Medicine , 1 (1) , 1-4 . DOI: 10.28982/josam.337791
MLA Aydın, A , Atadağ, Y , Öksüz, A , Kaya, D , Aydın, N . "Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study" . Journal of Surgery and Medicine 1 (2017 ): 1-4 <http://jsurgmed.com/en/pub/issue/31119/337791>
Chicago Aydın, A , Atadağ, Y , Öksüz, A , Kaya, D , Aydın, N . "Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study". Journal of Surgery and Medicine 1 (2017 ): 1-4
RIS TY - JOUR T1 - Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study AU - Abdülkadir Aydın , Yıldız Atadağ , Ahmet Öksüz , Didem Kaya , Nagehan Esra Aydın Y1 - 2017 PY - 2017 N1 - doi: 10.28982/josam.337791 DO - 10.28982/josam.337791 T2 - Journal of Surgery and Medicine JF - Journal JO - JOR SP - 1 EP - 4 VL - 1 IS - 1 SN - -2602-2079 M3 - doi: 10.28982/josam.337791 UR - https://doi.org/10.28982/josam.337791 Y2 - 2017 ER -
EndNote %0 Journal of Surgery and Medicine Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study %A Abdülkadir Aydın , Yıldız Atadağ , Ahmet Öksüz , Didem Kaya , Nagehan Esra Aydın %T Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study %D 2017 %J Journal of Surgery and Medicine %P -2602-2079 %V 1 %N 1 %R doi: 10.28982/josam.337791 %U 10.28982/josam.337791
ISNAD Aydın, Abdülkadir , Atadağ, Yıldız , Öksüz, Ahmet , Kaya, Didem , Aydın, Nagehan Esra . "Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study". Journal of Surgery and Medicine 1 / 1 (April 2017): 1-4 . https://doi.org/10.28982/josam.337791
AMA Aydın A , Atadağ Y , Öksüz A , Kaya D , Aydın N . Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study. J Surg Med. 2017; 1(1): 1-4.
Vancouver Aydın A , Atadağ Y , Öksüz A , Kaya D , Aydın N . Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study. Journal of Surgery and Medicine. 2017; 1(1): 1-4.
IEEE A. Aydın , Y. Atadağ , A. Öksüz , D. Kaya and N. Aydın , "Comparison of the Effects of Impaired Fasting Glucose and Impaired Glucose Tolerance on Diabetic Development Risks on HbA1c Levels: A Retrospective Study", Journal of Surgery and Medicine, vol. 1, no. 1, pp. 1-4, Apr. 2017, doi:10.28982/josam.337791