MRI histogram analysis of optic nerves in children with type 1 neurofibromatosis



Type 1 Neurofibromatosis, Image processing, Magnetic resonance imaging, Optic nerve


Background/Aim: Type 1 neurofibromatosis (NF1) is the most common neurocutaneous disease affecting numerous systems. Optic pathway glioma (OPG) is a common tumor in children with NF1 and often has variable clinical presentations. In this study, histogram analysis parameters of optic nerves were measured in the magnetic resonance images (MRI) of children with NF1 and compared with a control group. Methods: This case-control study consisted of three groups: Ten patients with NF1 without optic pathway glioma (bilateral optic nerve, n: 20), four patients with NF1 with bilateral optic pathway glioma (n: 8), and nineteen healthy controls (n: 38). ROIs were placed on bilateral pre-chiasmatic optic nerves in the images. With histogram analysis, average gray level intensity (mean), the standard deviation, minimum, median, and maximum intensity, uniformity, entropy, kurtosis, variance, skewness, size% M, size% U, size% L, and percentiles were measured. Results: Mean, median, 3%, 5%, 10%, 25%, and 75% values were higher in NF1 patients with optic pathway glioma (NF1-OPG) than in NF1 patients without optic pathway glioma (NF1-woOPG), and the control group (P<0.001). The same values were significantly higher in the NF1-woOPG group compared to the control group (P<0.001). The minimum, maximum, 1%, 90%, 95%, 97%, and 99% values were significantly higher in the NF1-OPG and NF1-woOPG groups than the control group (P<0.001). The entropy value was significantly higher in the NF1-OPG group than the NF1-woOPG and control groups (5.73, 4.93, and 5.25, respectively, P=0.016). Conclusion: MRI histogram analysis revealed significant differences between NF1-OPG, NF1-woOPG, and healthy individuals in terms of optic nerves. Thus, we think that it can be used to monitor the optic nerves of children with NF1.


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Eroğlu Y, Baykara M. MRI histogram analysis of optic nerves in children with type 1 neurofibromatosis. J Surg Med [Internet]. 2022 Jan. 1 [cited 2023 Feb. 6];6(1):68-71. Available from: