Evaluation of third-trimester neutrophil-lymphocyte and platelet-lymphocyte ratios and their correlation with birth weight

Mehmet Mete Kırlangıç; Osman Sade; Merve Vural; Esra Akdemir

doi:10.28982/josam.918863

Authors

Mehmet Mete Kırlangıç https://orcid.org/0000-0002-9750-1594
Osman Sade Tuzla Devlet Hastanesi https://orcid.org/0000-0001-9423-1544
Merve Vural Terme Devlet Hastanesi https://orcid.org/0000-0001-8933-9112
Esra Akdemir https://orcid.org/0000-0002-3776-0674

DOI:

https://doi.org/10.28982/josam.918863

Keywords:

Neutrophil lymphocyte ratio, NLR, Platelet lymphocyte ratio, PLR, Birth weight

Abstract

Background/Aim: Fetal development is affected by the maternal environment and one of the environment determinants is inflammation. Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) have been used as markers of inflammation in many disciplines. The aim of this study is to evaluate the relationship between the value of these easily accessible markers in the 3rd trimester and birth weight, which is the result of fetal development. Methods: This retrospective cohort study comprised 442 pregnant women who delivered within the last 2 years and met the inclusion criteria. As a result of a percentile adjustment made according to the Alexander growth curves, pregnant women were grouped according to the birth weight of their neonates, as normal birth weight (AGA) and large birth weight (LGA). Statistical analyses were conducted using the birth weights and hemogram parameters between the groups. Results: There was no significant difference in hemoglobin, neutrophil, platelet, NLR and PLR levels (P>0.05 for each) between the groups; however, a negative correlation was observed between lymphocyte and gestational weight (P=0.014). When comparing hemogram parameters between the groups, hemoglobin, neutrophil, platelet, NLR, and PLR counts were similar (P>0.05 for each). We observed that the lymphocyte counts were lower in the LGA group (P=0.019). There was no significant relationship between birth weight, and NLR and PLR counts during the third trimester (P=0.100, P=0.997, respectively). Conclusion: NLR and PLR counts are used in many disciplines as indicators of inflammation and have been used to predict many perinatal complications during pregnancy. In the present study, no relationship was found between fetal weight and third trimester NLR and PLR counts.

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