The association of TNFα -238 G/A gene polymorphism with alopecia areata
Keywords:TNFα, Gene polymorphism, Alopecia areata
Background/Aim: Alopecia areata (AA), which is characterized by hair loss, is an inflammatory autoimmune disease. Tumor necrosis factor-alpha (TNFα) is a potent proinflammatory cytokine that has a highly significant role in inflammatory and immune responses. The aim of this study is to evaluate whether there is a relationship between TNFα -238 G/A gene polymorphism and AA in the Turkish population. Methods: In this case-control study, the frequency of TNFα-238 G/A gene polymorphism and its relationship with some clinical parameters of AA patients were investigated. Seventy-eight AA patients and 78 healthy individuals were included in our study. TNFα -238 G/A polymorphism was evaluated by the PCR-RFLP method. Results: The distribution of TNFα -238 G/A genotypes was significantly different between patients and control subjects (P<0.001). Frequency of genotypes GG and AA in AA patients (53.8 and 6.4%, respectively) were evidently lower compared to the controls (59 and 25.6%, respectively). Individuals with AA genotype had a lower risk of AA disease [odds ratio (OR)=0.27; 95% CI=0.09-0.79; relative risk (RR)=0.65 (0.49-0.86); P=0.013]. GA genotype was significantly higher in patients with AA (39.7%) compared to the control group (15.4%) and an increased risk of patchy AA was observed [OR=2.82, 95% CI=1.28-6.21; RR=1.87 (1.11-3.15); P=0.008]. Conclusion: These results suggest that the TNFα -238 G/A gene polymorphism is associated with AA and individuals with GA genotype may have an increased risk of AA.
Safavi KH, Muller SA, Suman VJ et al. Incidence of alopecia areata in Olmsted County. Minnesota, 1975 through 1989. Mayo Clin Proc. 1995;70:628-33.
Dizen-Namdar N, Kocak FE, Kidir M et al. Evaluation of serum paraoxonase, arylesterase, prolidase activities and oxidative stress in patients with alopecia areata. Skin Pharmacol Physiol. 2019;32:59-64.
Cristina CS, Mauricio SS, Armando LR et al. Tumor necrosis factor alpha promoter- 308 G/A polymorphism in Mexican patients with patchy alopecia areata. Int J Dermatol. 2012;51:571-5.
Gillian M. Galbraith R, Pandey JR. Tumor necrosis factor alpha gene polymorphism in alopecia areata. Hum Genet. 1995;96:433-6.
Chen L, Huang Z, Liao Y, et al. Association between tumor necrosis factor polymorphisms and rheumatoid arthritis as well as systemic lupus erythematosus: a meta-analysis. Braz J Med Biol Res. 2019;52(3):e7927.
Aisha NM, Haroon J, Hussain S et al. Association between tumour necrosis-a gene polymorphisms and acne vulgaris in a Pakistani population. Clin Exp Dermatol. 2016;41:297-301.
Rajesh D, Gurumurthy R, Kutty AV, Balakrishna S. Tumor necrosis factor alpha gene promoter -238G/A polymorphism increases the risk of psoriasis vulgaris in Indian patients. Int J Dermatol. 2017;56(3):307-11.
Gilhar A, Paus R, Kalish RS. Lymphocytes, neuropeptides, and genes involved in alopecia areata. J Clin Invest. 2007;117:2019-27.
Olsen E, Hordinsky M, Price V et al. Alopecia areata investigational assessment guidelines – part II. J Am Acad Dermatol. 2004;51:440-7.
Tan FM, Yao HF, Lu HQ, Chen SQ. Study on the polymorphism of TNFα -238G/A and -308G/A gene in patients with alopecia areata. Journal of Clinical Dermatology. 2012;41(6):342-5.
Gulel A, Inaloz HS, Nursal AF et al. Association of the TNF-α, IL-2, and IL-2RB gene variants with susceptibility to psoriasis in a Turkish cohort. Cent Eur J Immunol. 2018;43(1):50-7.
Xu Y, Cao X, Jiang J et al. TNF-α-308/- 238 polymorphisms are associated with gastric cancer: A casecontrol family study in China. Clin Res Hepatol Gastroenterol. 2016;41:103-9.
Yu JY, Li L, Ma H et al. Tumor necrosis factor-a 238 G/A polymorphism and gastric cancer risk: A meta-analysis. Tumor Biol. 2013;34:3859-63.
Shafia S, Sofi FA, Dilafroze et al. The association between TNFα gene polymorphisms and susceptibility to rheumatoid arthritis in an ethnic Kashmiri population: relationship with disease activity and severity markers. Int J Rheum Dis. 2016;19(4):362-9.
Brinkman BMN, Huizinga TWJ, Kurban SS et al. Tumour Necrosis Factor a Gene polymorphisms in Rheumatoid arthritis: associated with susceptibility to/or severity of disease. Br J Rheumatol. 1997;36:516-21.
Fabris M, Di Poi E, Sacco S et al. TNF- alpha gene polymorphisms in rheumatoid arthritis patients treated with anti-TNF-alpha agents: preliminary results. Reumatismo. 2002;54(1):19-26.
Szabó K, Tax G, Teodorescu-Brinzeu D et al. TNFα gene polymorphisms in the pathogenesis of acne vulgaris. Arch Dermatol Res. 2011;303(1):19-27.
Wang B, He YL. Association of the TNF-α gene promoter polymorphisms at nucleotide -238 and -308 with acne susceptibility: a meta-analysis. Clin Exp Dermatol. 2019;44(2):176-83.
Schmeling H, Wagner U, Peterson A, Horneff G. Tumor necrosis factor alpha promoter polymorphisms in patients with juvenile idiopathic arthritis. Clin Exp Rheumatol. 2006;24(1):103-8.
Kaabachi S, Kaabachi W, Rafrafi A et al. Tumor necrosis factor gene polymorphisms in Tunisian patients with non-small cell lung cancer. Clin Lab. 2013;59(11-12):1389-95.
Philpott MP, Sanders DA, Bowen J, Kealey T. Effects of interleukins, colony-stimulating factor and tumour necrosis factor on human hair follicle growth in vitro, a possible role for interleukin-1 and tumour necrosis factor alpha in alopecia areata. Br J Dermatol. 1996;135:942-48.
Gohary YM, Abdel Fattah DS. Detection of Tumor Necrosis Factor-alpha in Nonlesional Tissues of Alopecia Areata Patients: A Prove for a Systemic Disease. Int J Trichology. 2017;9(4):154-9.
Abdel Halim D, Abu Zeid OM, Rashed L, Saleh MA. Alteration of serum and tissue tumor necrosis factor alpha levels: A possible mechanism of action of oral pulse steroids in the treatment of alopecia areata. J Cosmet Dermatol. 2019;8(4):1128-32.
How to Cite
Copyright (c) 2021 Nazlı Dizen Namdar, Raziye Akcılar
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Most read articles by the same author(s)
- Nazlı Dizen Namdar, İnci Arıkan, The relationship between alexithymia, anxiety, depression, and severity of the disease in psoriasis patients , Journal of Surgery and Medicine: Vol. 4 No. 3 (2020):