The clinical importance of triglyceride/glucose ratio in the primary prevention of cardiovascular diseases: A retrospective cohort study



Cardiovascular diseases, Coronary calcium score, Prevention


Background/Aim: Atherosclerosis plays a significant role in cardiovascular diseases. Dyslipidemia, inflammation, genetics, and environmental factors greatly impact the development and progression of atherosclerosis. This study aimed to investigate the importance of triglyceride-glucose ratio in primary cardiovascular event prevention. Methods: Our retrospective cohort study included 56 patients (39 males, 17 females). Coronary computed tomography angiography (CCTA) images of the individuals were examined, and calcium score was calculated using the Agatston score. Those with a score of zero and those with scores>0 were included in Groups 1 and 2, respectively. Triglyceride/glucose (TyG) ratio and atherosclerotic cardiovascular disease (ASCVD) risk were calculated for all individuals. Results: Among all patients, 69.6% had coronary artery calcium scores (CACs) of greater than zero. The TyG ratios were 0.92 (0.33) and 1.77 (0.83) in Groups 1 and 2, respectively (P<0.001). The ASCVD risk was 4.17 (4.92) in Group 1, and 16.24 (10.66) in Group 2 (P<0.001). The TyG ratio was positively correlated with calcium score and ASCVD risk (r=0.717, P<0.001 and r=0.456, P<0.001, respectively). TyG ratio (OR=33.132, 95% CI=4.404-249.254, P=0.001) predicted CACs in CTBA in the univariate logistic analysis. The cut-off level for the TyG ratio in the prediction of coronary atherosclerosis was 1.04, with a sensitivity of 74%, and a specificity of 88% (AUC=0.84, P<0.001). Conclusion: The present study showed that the TyG ratio could assist the current risk assessment scores used for primary prevention in cardiovascular diseases.


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Küçük U, Duygu A, Gazi E. The clinical importance of triglyceride/glucose ratio in the primary prevention of cardiovascular diseases: A retrospective cohort study. J Surg Med [Internet]. 2021 Oct. 1 [cited 2024 Apr. 23];5(10):1020-3. Available from: