Beta cell function as an assessment tool for cardiovascular risk in patients with metabolic syndrome

Authors

Keywords:

Metabolic syndrome, C-peptide, Epicardial fat tissue, Cardiovascular risk

Abstract

Background/Aim: Epicardial fat tissue (EFT) is considered a cardiovascular risk factor independent from visceral adiposity, obesity, hypertension, and diabetes. Fasting serum C-peptide is a known marker of endogenous insulin secretion and beta cell function. Our aim was to evaluate C- peptide levels in patients with metabolic syndrome (MetS) in relation to the EFT thickness. Methods: Forty-five subjects with MetS without a history of coronary artery disease and 25 healthy volunteers were enrolled this prospective case-control study. We examined the laboratory values, including C peptide, insulin, and HOMA-IR after 8 hours of fasting. EFT thickness was measured by two-dimensional transthoracic echocardiography. Results: The serum C peptide levels were significantly higher in patients with metabolic syndrome compared to the healthy controls [3.41(1.98) ng/ml vs 2.07 (1.39), P<0.001]. C peptide levels were correlated with BMI (P=0.03, r=0.281) and serum triglycerides (P=0.03, r=0.288). Patients with MetS had remarkably high EFT thickness [0.63(0.22) mm, P=0.043]. EFT thickness was correlated with age (P=0.008, r=0.397), weight (P=0042, r=0.308) and C-peptide (P=0.002, r=0.460) in patients with MetS. Conclusion: EFT thickness and elevated C-peptide are independent risk factors influencing atherosclerosis. The strong association between EFT thickness and C-peptide demonstrated herein indicates that EFT may play an important role in C peptide secretion, possibly contributing to the cardiometabolic risk in patients with MetS.

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Published

2021-10-01

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Research Article

How to Cite

1.
Erman H, Böyük B, Cetın SI, Sevınc S, Bulut U, Maviş O. Beta cell function as an assessment tool for cardiovascular risk in patients with metabolic syndrome. J Surg Med [Internet]. 2021 Oct. 1 [cited 2022 Sep. 28];5(10):1002-6. Available from: https://jsurgmed.com/article/view/847350