The effect of dietary total antioxidant capacity of individuals with type 2 diabetes on metabolic and oxidative parameters: A cross-sectional study: Dietary antioxidant capacity in type 2 diabetes

Özlem Özpak Akkuş; Meltem Mermer; Ramazan Gen; Mehmet Burak Yavuz Çimen; Antonios Koutelidakis; İhsan Dönmez

doi:10.28982/josam.8381

Authors

Özlem Özpak Akkuş Toros University, Department of Nutrition and Dietetic, Mersin, Turkey https://orcid.org/0000-0002-1471-8000
Meltem Mermer Toros University, Department of Nutrition and Dietetic, Mersin, Turkey https://orcid.org/0000-0001-5264-3356
Ramazan Gen Mersin University, Faculty of Medicine, Department of Endocrinology and Metabolism, Mersin, Turkey https://orcid.org/0000-0001-6558-6354
Mehmet Burak Yavuz Çimen Mersin University, Faculty of Medicine, Department of Medical Biochemistry, Mersin, Turkey https://orcid.org/0000-0002-1274-3499
Antonios Koutelidakis University of Aegean, Unit of Human Nutrition, Laboratory of Nutrition and Public Health, Department of Food Science and Nutrition, Myrina, Greece https://orcid.org/0000-0001-5137-0499
İhsan Dönmez Mersin University, Faculty of Medicine, Department of Medical Biochemistry, Mersin, Turkey https://orcid.org/0000-0002-7083-7194

DOI:

https://doi.org/10.28982/josam.8381

Keywords:

Type 2 diabetes, Dietary total antioxidant capacity, Glycemic control, Oxidative parameters, Metabolic parameters

Abstract

Background/Aim: The aim of this study is to determine the dietary total antioxidant capacity (DTAC) values and levels of certain serum oxidative parameters in individuals with previously and newly diagnosed type 2 diabetes and to evaluate the impact of these findings on glycemic values and metabolic parameters.

Methods: This study was conducted with a total of 97 participants aged 19-64, comprising 35 individuals with a previous type 2 diabetes diagnosis, 32 individuals with a recent type 2 diabetes diagnosis, and 30 healthy participants. During face-to-face interviews, participants provided descriptive information, physical activity levels, and anthropometric measurements. DTAC was calculated from three-day dietary intake records using various methods. Serum samples were collected for the analysis of glycemic, lipid, and oxidative parameters.

Results: The results show that DTAC values (specifically derived from total radical-trapping antioxidant potential (TRAP) and total phenolics (TP) values)) and serum TAC levels tend to decrease with both prolonged diabetes age and when compared to individuals without diabetes (P<0.05). DTAC values were found to have a significant effect on some oxidative parameters like TAC, paraoxonase 1, and arylesterase (P<0.05), while serum oxidative parameters were found to have no significant effect on glycemic and lipid parameters.

Conclusion: It was concluded that low DTAC may be a risk factor related to oxidative stress depending on type 2 diabetes and diabetes age.

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