The effect of turmeric on primary dysmenorrhea: Prospective case-control study

Authors

Keywords:

Naproxen, Primary dysmenorrhea, Turmeric, Visual analog scale

Abstract

Background/Aim: Turmeric is an ancient spice and is still a part of dietary traditions, especially in Asian populations. It has been linked to anti-inflammatory effects; thus, it may be effective in dysmenorrhea which occurs due to inflammatory events. The use of turmeric in the treatment of dysmenorrhea is unclear. We aimed to compare the effectiveness of turmeric when included in dysmenorrhea treatment. Methods: Nulliparous patients with primary dysmenorrhea (PD) who met the inclusion criteria were included in our prospective case-control study. After the diagnosis of PD was confirmed by the clinician, patients were asked to choose one of the covered papers that wrote group 1 (Control, n=75) and group 2 (Case, n=75), after which they received their related treatment from the doctor in another examination room. Naproxen (750 mg/day) was prescribed to all patients, and 1 g/day turmeric powder was added to the treatment protocol of Group 2 patients as a food supplement to be consumed peroral during menstrual bleeding. The turmeric supplements were given to the patients by the assisting nurse. The two groups were asked to score their pain with a visual analog scale (VAS) before and after the treatment, which were comparatively analyzed. All patients signed informed consent forms before the study began. Results: The two groups were similar in terms of age (22.7 years vs. 23.5 years, p=0.408). The overall median pain score of the study population before the treatment was 9.17 (range: 5-10), which decreased to 2.81 (range: 1-5) after the treatment, with a Z-score of -10.64. The decrease in VAS scores was significant in both groups (P=0.001 for both). The percentage of VAS score decrease (61.7% vs 76.8%) and the absolute score decrease (5.6 vs 7.0) were significantly higher in Group 2 compared to Group 1 (P=0.001, for both). Conclusion: Turmeric may have a role in PD treatment. Naproxen is an effective agent in PD treatment and concomitant use with turmeric improves pain scores. Further controlled randomized studies investigating turmeric use in PD treatment and its mechanism of action may contribute to the literature.

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References

Chen CX, Kwekkeboom KL, Ward SE. Self-report pain and symptom measures for primary dysmenorrhoea: a critical review. Eur J Pain. 2015 Mar;19(3):377-91. doi: 10.1002/ejp.556. PMID: 25059384.

Iacovides S, Avidon I, Baker FC. What we know about primary dysmenorrhea today: a critical review. Hum Reprod Update. 2015 Nov-Dec;21(6):762-78. doi: 10.1093/humupd/dmv039. Epub 2015 Sep 7. PMID: 26346058.

Dawood MY. Primary dysmenorrhea: advances in pathogenesis and management. Obstet Gynecol. 2006 Aug;108(2):428-41. doi: 10.1097/01.AOG.0000230214.26638.0c. PMID: 16880317.

Lundström V, Gréen K. Endogenous levels of prostaglandin F2alpha and its main metabolites in plasma and endometrium of normal and dysmenorrheic women. Am J Obstet Gynecol. 1978 Mar 15;130(6):640-6. doi: 10.1016/0002-9378(78)90320-4. PMID: 637076.

Marjoribanks J, Ayeleke RO, Farquhar C, Proctor M. Nonsteroidal anti-inflammatory drugs for dysmenorrhoea. Cochrane Database Syst Rev. 2015 Jul 30;2015(7):CD001751. doi: 10.1002/14651858.CD001751.pub3. PMID: 26224322; PMCID: PMC6953236.

Brutzkus JC, Shahrokhi M, Varacallo M. Naproxen. 2021 May 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30247840.

Carrarelli P, Funghi L, Bruni S, Luisi S, Arcuri F, Petraglia F. Naproxen sodium decreases prostaglandins secretion from cultured human endometrial stromal cells modulating metabolizing enzymes mRNA expression. Gynecol Endocrinol. 2016;32(4):319-22. doi: 10.3109/09513590.2015.1115973. Epub 2015 Dec 3. PMID: 26634864.

Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: a component of tumeric (Curcuma longa). J Altern Complement Med. 2003 Feb;9(1):161-8. doi: 10.1089/107555303321223035. PMID: 12676044.

Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J. 2013 Jan;15(1):195-218. doi: 10.1208/s12248-012-9432-8. Epub 2012 Nov 10. PMID: 23143785; PMCID: PMC3535097.

Goel A, Boland CR, Chauhan DP. Specific inhibition of cyclooxygenase-2 (COX-2) expression by dietary curcumin in HT-29 human colon cancer cells. Cancer Lett. 2001 Oct 30;172(2):111-8. doi: 10.1016/s0304-3835(01)00655-3. PMID: 11566484.

Ramsewak RS, DeWitt DL, Nair MG. Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longa. Phytomedicine. 2000 Jul;7(4):303-8. doi: 10.1016/S0944-7113(00)80048-3. PMID: 10969724.

Aggarwal BB, Deb L, Prasad S. Curcumin differs from tetrahydrocurcumin for molecular targets, signaling pathways and cellular responses. Molecules. 2014 Dec 24;20(1):185-205. doi: 10.3390/molecules20010185. PMID: 25547723; PMCID: PMC6272158.

French L. Dysmenorrhea. Am Fam Physician. 2005 Jan 15;71(2):285-91. PMID: 15686299.

Jenabi E. The effect of ginger for relieving of primary dysmenorrhoea. J Pak Med Assoc. 2013 Jan;63(1):8-10. PMID: 23865123.

Pattanittum P, Kunyanone N, Brown J, Sangkomkamhang US, Barnes J, Seyfoddin V, et al. Dietary supplements for dysmenorrhoea. Cochrane Database Syst Rev. 2016 Mar 22;3(3):CD002124. doi: 10.1002/14651858.CD002124.pub2. PMID: 27000311; PMCID: PMC7387104.

Daverey A, Agrawal SK. Curcumin alleviates oxidative stress and mitochondrial dysfunction in astrocytes. Neuroscience. 2016 Oct 1;333:92-103. doi: 10.1016/j.neuroscience.2016.07.012. Epub 2016 Jul 14. PMID: 27423629.

Funk JL, Oyarzo JN, Frye JB, Chen G, Lantz RC, Jolad SD. et al, Timmermann BN. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat Prod. 2006 Mar;69(3):351-5. doi: 10.1021/np050327j. PMID: 16562833; PMCID: PMC2533857.

Roger P Smith, MDAndrew M Kaunitz, MD. Dysmenorrhea in adult women: Treatment. UpToDate Inc. https://www.uptodate.com (Accessed on May 05, 2020).

Daniels SE, Paredes-Diaz A, An R, Centofanti R, Tajaddini A. Significant, long-lasting pain relief in primary dysmenorrhea with low-dose naproxen sodium compared with acetaminophen: a double-blind, randomized, single-dose, crossover study. Curr Med Res Opin. 2019 Dec;35(12):2139-2147. doi: 10.1080/03007995.2019.1654987. Epub 2019 Aug 28. PMID: 31397597.

FKAI. Health Secret of Turmeric (Kunyit). 2011. Jakarta: PT. Elex Media Computindo.

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Published

2021-07-01

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Research Article

How to Cite

1.
Okuyan E, Günakan E, Atac H, Çakmak Y. The effect of turmeric on primary dysmenorrhea: Prospective case-control study. J Surg Med [Internet]. 2021 Jul. 1 [cited 2022 Oct. 7];5(7):715-7. Available from: https://jsurgmed.com/article/view/828571