The effect of vitamin K1 and vitamin K2 on mortality rate and disease severity in COVID-19 patients: An observational study
Vitamin K and COVID-19 outcomes
Authors
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Demet Tekdos Demircioglu
Istanbul Aydin University Medical School, Physical Medicine and Rehabilitation Department, Istanbul, Turkey
https://orcid.org/0000-0001-5946-3542
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Dilay Karabulut
Istanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Cardiology, Istanbul Turkey
https://orcid.org/0000-0003-1896-0096
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Pinar Kasapoglu
Istanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Biochemistry, Istanbul, Turkey
https://orcid.org/0000-0003-1703-2204
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Esra Canbolat Unlu
Istanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Infectious Disease, Istanbul, Turkey
https://orcid.org/0000-0003-1465-3283
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Kadriye Kart Yasar
Istanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Infectious Disease, Istanbul, Turkey
https://orcid.org/0000-0003-2963-4894
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Nilgun Isıksacan
Istanbul Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Biochemistry, Istanbul, Turkey
https://orcid.org/0000-0002-0230-6500
Keywords:
COVID-19, Inflammation, Mortality, vitamin K1, vitamin K2Abstract
Background/Aim: Vitamin K is vital for numerous physiological functions, particularly in coagulation and inflammation. This research investigates the relationship between VK1 and VK2 levels and the severity and mortality of COVID-19
Methods: This prospective study analyzed VK1 and VK2 levels using ELISA in 165 hospitalized COVID-19 patients. Statistical analyses, including logistic regression, were performed to evaluate associations with clinical outcomes, including ICU admission and mortality.
Results: VK2 levels were significantly higher in patients with severe disease (P<0.01) and deceased patients (P<0.05). Logistic regression identified CT severity and VK1 levels as risk factors for ICU admission and mortality, with odds ratios of 10.65 and 6.43, respectively.
Conclusion Elevated VK2 levels correlated with severe COVID-19 outcomes, suggesting a potential role as a biomarker for disease severity and risk of mortality. These findings underscore the potential clinical utility of VK2 as a biomarker for disease severity and prognosis.
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Mikami T, Miyashita H, Yamada T, Harrington, M, Steinberg, D, Dunn A. Risk Factors for Mortality in Patients with COVID-19 in New York City. J Gen Intern Med. 2021;36:17–26. DOI: https://doi.org/10.1007/s11606-020-05983-z
Perlman S, Netland, J. Coronaviruses post-SARS: update on replication and pathogenesis. Nat Rev Microbiol. 2009;7:439–50. DOI: https://doi.org/10.1038/nrmicro2147
Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395:497–506. DOI: https://doi.org/10.1016/S0140-6736(20)30183-5
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395:507–13. DOI: https://doi.org/10.1016/S0140-6736(20)30211-7
Emami A, Javanmardi F, Pirbonyeh N, Akbari A. Prevalence of Underlying Diseases in Hospitalized Patients with COVID-19: a Systematic Review and Meta-Analysis. Arch Acad Emerg Med. 2020;8:e35. DOI: https://doi.org/10.1371/journal.pone.0241265
Wang X, Fang X, Cai Z, Wu X, Gao, X, Min, J, et al. Comorbid Chronic Diseases and Acute Organ Injuries Are Strongly Correlated with Disease Severity and Mortality among COVID-19 Patients: A Systemic Review and Meta-Analysis. Research (Wash D C). 2020;2402961. DOI: https://doi.org/10.34133/2020/2402961
Fu L, Wang B, Yuan T, Chen X, Ao Y, Fitzpatrick T, et al. Clinical characteristics of coronavirus disease 2019 (COVID-19) in China: A systematic review and meta-analysis. J Infect. 2020;80:656–65. DOI: https://doi.org/10.1016/j.jinf.2020.03.041
Hu Y, Sun J, Dai Z, Deng H, Li X, Huang Q, et al. Prevalence and severity of corona virus disease 2019 (COVID-19): A systematic review and meta-analysis. J Clin Virol. 2020;127:104371. DOI: https://doi.org/10.1016/j.jcv.2020.104371
Rodriguez-Morales AJ, Cardona-Ospina JA Gutierrez-Ocampo E, Villamizar-Peña R, Holguin-Rivera Y, et al. Latin American Network of Coronavirus Disease 2019-COVID-19 Research (LANCOVID-19) Clinical, laboratory and imaging features of COVID-19: A systematic review and meta-analysis. Travel Med Infect Dis. 2020;34:101623. DOI: https://doi.org/10.1016/j.tmaid.2020.101623
Lippi G, Wong J, Henry BM. Hypertension and its severity or mortality in coronavirus disease 2019 (COVID-19): a pooled analysis. Pol Arch Intern Medn. 2020;130:304–9. DOI: https://doi.org/10.20452/pamw.15272
Kumar A, Arora A, Sharma P, Anikhindi SA, Bansal N, Singla V, et al. Is diabetes mellitus associated with mortality and severity of COVID-19? A meta-analysis. Diabetes Metab Syndr. 2020;14:535–45. DOI: https://doi.org/10.1016/j.dsx.2020.04.044
Huang I, Lim MA, Pranata R. Diabetes mellitus is associated with increased mortality and severity of disease in COVID-19 pneumonia - A systematic review, meta-analysis, and meta-regression. Diabetes Metab Syndr. 2020;14:395–403. DOI: https://doi.org/10.1016/j.dsx.2020.04.018
Pranata R, Huang I, Lim MA, Wahjoepramono PEJ. July J. Impact of Cerebrovascular and Cardiovascular Diseases on Mortality and Severity of COVID-19 Systematic Review, Meta-analysis, and Meta-regression. J Stroke Cerebrovasc Dis. 2020;29:104949. DOI: https://doi.org/10.1016/j.jstrokecerebrovasdis.2020.104949
Pranata R, Lim MA, Huang I, Raharjo SB, Lukito AA. Hypertension is associated with increased mortality and severity of disease in COVID-19 pneumonia: A systematic review, meta-analysis and meta-regression. J Renin Angiotensin Aldosterone Syst. 2020;21:1470320320926899. DOI: https://doi.org/10.1177/1470320320926899
Petrill CM, Jones SA, Yang J, Rajagopalan H, O’Donnell L, Chernyak Y, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;369:m1966. DOI: https://doi.org/10.1136/bmj.m1966
Marrazzo F, Spina S, Zadek F, Lama T, Xu, C, Larson G, et al. Protocol of a randomised controlled trial in cardiac surgical patients with endothelial dysfunction aimed to prevent postoperative acute kidney injury byadministering nitric oxide gas. BMJ open. 2020;9:e026848. DOI: https://doi.org/10.1136/bmjopen-2018-026848
Frantzeskaki F, Armaganidis A, Orfanos SE. Immunothrombosis in acute respiratory distress syndrome: cross talks between inflammation and coagulation. Respiration. 2017;93:212–25. DOI: https://doi.org/10.1159/000453002
Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020;18.844–7. DOI: https://doi.org/10.1111/jth.14768
Cui S, Chen S, Li X, Liu S. Wang F. Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia. J Thromb Haemost. 2020;18:1421–4. DOI: https://doi.org/10.1111/jth.14830
Halder M, Petsophonsakul P, Akbulut AC., Pavlic A, Bohan F, Anderson E, et al. Vitamin K: double bonds beyond coagulation insights into differences between vitamin K1 and K2 in health and disease. Int J Mol Sci. 2019;20:896. DOI: https://doi.org/10.3390/ijms20040896
Zhou, F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395:1054–62. DOI: https://doi.org/10.1016/S0140-6736(20)30566-3
Chang YC, Yu CJ, Chang SC, Galvin JR, Liu HM, Hsiao CH. Pulmonary sequelae in convalescent patients after severe acute respiratory syndrome: evaluation with thin-section CT. Radiology. 2005;236:1067–75. DOI: https://doi.org/10.1148/radiol.2363040958
Dofferhoff ASM, Piscaer I, Schurgers LJ, Walk J, Van Den Ouweland JM, Hackeng TM, et al. Reduced vitamin K status as a potentially modifiable risk factor of severe coronavirus disease 2019. Clin Infect Dis. 2021;73:e4039-e4046. DOI: https://doi.org/10.1093/cid/ciaa1258
Ohsaki Y, Shirakawa H, Hiwatashi K, Furukawa Y, Mizutani T, Komai M. Vitamin K suppresses lipopolysaccharide-induced inflammation in the rat. Biosci Biotechnol Biochem. 2006;70:926–32. DOI: https://doi.org/10.1271/bbb.70.926
Sacks D, Baxter B, Campbell BCV, Carpenter JS, Cognard C, Dippel D, et al. Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke: From the American Association of Neurological Surgeons (AANS), American Society of Neuroradiology (ASNR), Cardiovascular and Interventional Radiology Society of Europe (CIRSE), Canadian Interventional Radiology Association (CIRA), Congress of Neurological Surgeons (CNS), European Society of Minimally Invasive Neurological Therapy (ESMINT), European Society of Neuroradiology (ESNR), European Stroke Organization (ESO), Society for Cardiovascular Angiography and Interventions (SCAI), Society of Interventional Radiology (SIR), Society of NeuroInterventional Surgery (SNIS), and World Stroke Organization. (WSO) J Vasc Interv Radiol. 2018;29:441–53. DOI: https://doi.org/10.1016/j.jvir.2017.11.026
Theuwissen E, Smit E, Vermeer C. The role of vitamin K in soft-tissue calcification. Adv Nutr. 2012;3:166–73. DOI: https://doi.org/10.3945/an.111.001628
Adams M, Katz D, Grandpre J. Population-based estimates of chronic conditions affecting risk for complications from coronavirus disease, United States. Emerg Infect Dis. 2020;26:1831–3. DOI: https://doi.org/10.3201/eid2608.200679
Ji Y, Ma Z, Peppelenbosch MP, Pan Q. Potential association between COVID-19 mortality and health-care resource availability. Lancet Glob Health. 2020;8:e480. DOI: https://doi.org/10.1016/S2214-109X(20)30068-1
Govers C, Calder PC, Savelkoul HFJ, Albers R, van Neerven RJJ. Ingestion, Immunity, and Infection: Nutrition and Viral Respiratory Tract Infections. Front Immunol. 2022;28(13):841532. DOI: https://doi.org/10.3389/fimmu.2022.841532
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Copyright (c) 2025 Demet Tekdos Demircioglu, Dilay Karabulut, Pinar Kasapoglu, Esra Canbolat Unlu, Kadriye Kart Yasar, Nilgun Isıksacan
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