The association between surgery type and heart-specific mortality in male breast cancer: Heart-specific mortality in male breast cancer

Ahmet Necati Sanlı

doi:10.28982/josam.7844

Authors

Ahmet Necati Sanlı Department of General Surgery, Abdulkadir Yuksel State Hospital, Gaziantep, Turkey https://orcid.org/0000-0002-1483-8176

DOI:

https://doi.org/10.28982/josam.7844

Keywords:

male breast cancer, disease of heart, survival

Abstract

Background/Aim: Male breast cancer, while less prevalent than female breast cancer, remains a significant health concern for men. Heart-specific mortality presents a significant worry for male breast cancer patients, as treatment and underlying comorbidities may increase their risk for cardiovascular complications. The purpose of this study was to investigate the associations between the type of surgery and heart-specific mortality in male breast cancer patients.

Methods: Data were extracted from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) 17 tumor registry database. The study encompassed a total of 86 male breast cancer patients who succumbed to heart disease. Patients with missing data on key variables were excluded. We divided the patients into two groups based on the type of surgery they received: breast-conserving surgery (BCS) and mastectomy.

Results: The mean age of the BCS group was 78.9 years, while the mean age of the Mastectomy group was 74.7 years. The tumor was most commonly located in the center on both sides. There was no statistically significant difference in the ethnic composition of the groups. All patients in both groups were estrogen receptor (ER) positive. Grade 1 tumors were more prevalent in the BCS group, and Grade 3 tumors were more prevalent in the Mastectomy group. The survival rates did not significantly differ between the two types of surgeries.

Conclusion: This study suggests that the type of surgery (BCS or mastectomy) does not significantly affect heart-specific mortality in male breast cancer patients. For a deeper understanding of any additional factors impacting heart-related outcomes in this cohort, further research is required.

Downloads

References

Gucalp A, Traina TA, Eisner JR, Parker JS, Selitsky SR, Park BH, et al. Male breast cancer: a disease distinct from female breast cancer. Breast Cancer Res Treat. 2019 Jan;173(1):37-48. doi: 10.1007/s10549-018-4921-9. DOI: https://doi.org/10.1007/s10549-018-4921-9

Fentiman IS. Surgical options for male breast cancer. Breast Cancer Res Treat. 2018 Dec;172(3):539-44. doi: 10.1007/s10549-018-4952-2. DOI: https://doi.org/10.1007/s10549-018-4952-2

Bradshaw PT, Stevens J, Khankari N, Teitelbaum SL, Neugut AI, Gammon MD. Cardiovascular Disease Mortality Among Breast Cancer Survivors. Epidemiology. 2016 Jan;27(1):6-13. doi: 10.1097/EDE.0000000000000394. DOI: https://doi.org/10.1097/EDE.0000000000000394

Curigliano G, Lenihan D, Fradley M, Ganatra S, Barac A, Blaes A, et al.; ESMO Guidelines Committee. Management of cardiac disease in cancer patients throughout oncological treatment: ESMO consensus recommendations. Ann Oncol. 2020 Feb;31(2):171-90. doi: 10.1016/j.annonc.2019.10.023. P DOI: https://doi.org/10.1016/j.annonc.2019.10.023

Yildirim E, Berberoglu U. Male breast cancer: a review of clinical features, imaging and pathology. Indian J Radiol Imaging. 2015;25(3):264-71.

Korde LA, Zujewski JA, Kamin L, Giordano S, Domchek S, Anderson WF, et al. Multidisciplinary meeting on male breast cancer: summary and research recommendations. J Clin Oncol. 2010;28(12):2114-22.

Fentiman IS, Fourquet A, Hortobagyi GN. Male breast cancer. Lancet. 2006;367(9510):595-604. DOI: https://doi.org/10.1016/S0140-6736(06)68226-3

Smith LI, Dayal S, Murray J, Lannigan A. Attitudes towards breast conservation in patients aged over 70 with breast cancer. Springerplus. 2016 Apr 18;5:478. doi: 10.1186/s40064-016-2133-5. DOI: https://doi.org/10.1186/s40064-016-2133-5

Sauder CAM, Bateni SB, Davidson AJ, Nishijima DK. Breast Conserving Surgery Compared With Mastectomy in Male Breast Cancer: A Brief Systematic Review. Clin Breast Cancer. 2020 Jun;20(3):e309-14. doi: 10.1016/j.clbc.2019.12.004. DOI: https://doi.org/10.1016/j.clbc.2019.12.004

Nahleh Z, Girnius S, Garcia S. Male breast cancer in the veterans affairs population: a comparative analysis. Cancer. 2007;109(7):1471-7. DOI: https://doi.org/10.1002/cncr.22589

Korde LA, Zujewski JA, Kamin L, Giordano S, Domchek S, Anderson WF, et al. Multidisciplinary meeting on male breast cancer: summary and research recommendations. J Clin Oncol. 2010 Apr 20;28(12):2114-22. doi: 10.1200/JCO.2009.25.5729.

Konduri S, Singh M, Bobustuc G, Rovin R, Kassam A. Epidemiology of male breast cancer. Breast. 2020 Dec;54:8-14. doi: 10.1016/j.breast.2020.08.010. DOI: https://doi.org/10.1016/j.breast.2020.08.010

Özgür C, Sunal BS, Tunçbilek N. A Rare Case of Bilateral Synchronous Male Breast Cancer: A Multimodality Approach. Eur J Breast Health 2022;18:199-202. doi: 10.4274/ejbh.galenos.2021.2021-9-7 DOI: https://doi.org/10.4274/ejbh.galenos.2021.2021-9-7

Łukasiewicz S, Czeczelewski M, Forma A, Baj J, Sitarz R, Stanisławek A. Breast Cancer-Epidemiology, Risk Factors, Classification, Prognostic Markers, and Current Treatment Strategies-An Updated Review. Cancers (Basel). 2021 Aug 25;13(17):4287. doi: 10.3390/cancers13174287. DOI: https://doi.org/10.3390/cancers13174287

Gnerlich JL, Deshpande AD, Jeffe DB, Seelam S, Kimbuende E, Margenthaler JA. Poorer survival outcomes for male breast cancer compared with female breast cancer may be attributable to in-stage migration. Ann Surg Oncol. 2011 Jul;18(7):1837-44. doi: 10.1245/s10434-010-1468-3. DOI: https://doi.org/10.1245/s10434-010-1468-3

Park S, Hur H, Lee JS, Yoon J, Hur SM, Chung IY, et al. Prognostic Factors in Male Breast Cancer: A Retrospective Nationwide Study in South Korea by the Study of SMARTSHIP Group. J Breast Cancer. 2021 Dec;24(6):561-8. doi: 10.4048/jbc.2021.24.e54. DOI: https://doi.org/10.4048/jbc.2021.24.e54

Korde LA, Zujewski JA, Kamin L, Giordano S, Domchek S, Anderson WF, et al. Multidisciplinary meeting on male breast cancer: summary and research recommendations. J Clin Oncol. 2010 Apr 20;28(12):2114-22. doi: 10.1200/JCO.2009.25.5729. DOI: https://doi.org/10.1200/JCO.2009.25.5729

Reyna VF, Nelson WL, Han PK, Pignone MP. Decision making and cancer. Am Psychol. 2015 Feb-Mar;70(2):105-18. doi: 10.1037/a0036834. DOI: https://doi.org/10.1037/a0036834