Demographic characteristics of patients with anosmia consulting to the COVID-19 outpatient clinic
Anosmia and COVID-19
Keywords:
COVID 19, anosmia, outpatientAbstract
Background/Aim: Coronavirus disease 2019 (COVID-19) cases first emerged in Turkey in March 2020, spreading rapidly and peaking in April and May. This study aimed to assess individuals with loss of taste and smell who were admitted to our hospital with a COVID-19 diagnosis.
Methods: Between March and June 2020, we retrospectively assessed 6966 patients who visited Kartal Dr. Lütfi Krdar City Hospital’s Infectious Diseases and Clinical Microbiology COVID-19 outpatient clinics; 137 patients with loss of taste and smell were included in the study. We enrolled 18-year-old patients who were admitted to the infection emergency outpatient clinics.
Results: Out of the 6966 patients hospitalized with a pre-diagnosis of COVID-19 infection, 137 (0.19%) complained of poor taste and smell. Among these, 69 (50.4%) were female, and 68 (49.6%) were male. Of the 137 patients, 100 (73%) reported a loss of smell, while 94 (68.6%) reported a loss of taste. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RT-PCR (reverse transcriptase-polymerase chain reaction) was positive in approximately one-third (n=2672, 38.4%) of the 6966 patients and roughly half (n=62, 48.4%) of the patients with loss of taste and smell. The most common symptoms observed in patients with anosmia were fever (n=123, 91%), cough (n=102, 75%), shortness of breath (n=411, 30%), sore throat (n=12, 9%), malaise (n=12, 9%), myalgia (n=11, 8%), nausea/vomiting (n=6, 5%), diarrhea (n=4, 3%), loss of smell (n=2, 2%), and loss of taste (n=2, 2%). Comorbidities included hypertension (n=4, 3%), diabetes mellitus (n=4, 2%), chronic obstructive pulmonary disease (n=2, 2%), and coronary artery disease (n=1, 1%).
Conclusion: Patients admitted to our hospital during the initial wave of the pandemic experienced typical and prevalent symptoms such as fever, cough, shortness of breath, sore throat, and loss of taste and smell. Further large cohort studies are required to address the “tasteless” COVID-19 more fully.
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Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19). J Gen Intern Med. 2020 May;35(5):1545-9. doi: 10.1007/s11606-020-05762-w. Epub 2020 Mar 4. PMID: 32133578; PMCID: PMC7088708. DOI: https://doi.org/10.1007/s11606-020-05762-w
Hassan SA, Sheikh FN, Jamal S, Ezeh JK, Akhtar A. Coronavirus (COVID-19): A Review of Clinical Features, Diagnosis, and Treatment. Cureus. 2020 Mar 21;12(3):e7355. doi: 10.7759/cureus.7355. PMID: 32328367; PMCID: PMC7170025. DOI: https://doi.org/10.7759/cureus.7355
Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. China Medical Treatment Expert Group for Covid-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Apr 30;382(18):1708-20. doi: 10.1056/NEJMoa2002032. Epub 2020 Feb 28. PMID: 32109013; PMCID: PMC7092819.
Izquierdo-Dominguez A, Rojas-Lechuga MJ, Mullol J, Alobid I. Olfactory Dysfunction in the COVID-19 Outbreak. J Investig Allergol Clin Immunol. 2020;30(5):317-26. doi: 10.18176/jiaci.0567. Epub 2020 May 14. PMID: 32406374. DOI: https://doi.org/10.18176/jiaci.0567
Lee Y, Min P, Lee S, Kim SW. Prevalence and Duration of Acute Loss of Smell or Taste in COVID-19 Patients. J Korean Med Sci. 2020 May 11;35(18):e174. doi: 10.3346/jkms.2020.35.e174. PMID: 32383370; PMCID: PMC7211515. DOI: https://doi.org/10.3346/jkms.2020.35.e174
Koeppen B. Mand Stanton B A. The Special Senses. Berneand Levy Physiology, Seventh Edition. 2018. Book Chapter. 8,127-160.
Hjelmesæth J, Skaare D. Loss of smell or taste as the only symptom of COVID-19. Tidsskr Nor Laegeforen. 2020 Apr 3;140(7). English, Norwegian. doi: 10.4045/tidsskr.20.0287. PMID: 32378854. DOI: https://doi.org/10.4045/tidsskr.20.0287
Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. 2020;12:8. doi: 10.1038/s41368-020-0074-x DOI: https://doi.org/10.1038/s41368-020-0074-x
Lechien JR, Chiesa-Estomba CM, De Siati DR, Horoi M, Le Bon SD, Rodriguez A, et al. Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study. Eur Arch Otorhinolaryngol. 2020 Aug;277(8):2251-61. doi: 10.1007/s00405-020-05965-1. Epub 2020 Apr 6. PMID: 32253535; PMCID: PMC7134551. DOI: https://doi.org/10.1007/s00405-020-05965-1
Pan F, Ye T, Sun P, Gui S, Liang B, Li L, et al. Time Course of Lung Changes at Chest CT during Recovery from Coronavirus Disease 2019 (COVID-19). Radiology. 2020 Jun;295(3):715-21. doi: 10.1148/radiol.2020200370. Epub 2020 Feb 13. PMID: 32053470; PMCID: PMC7233367. DOI: https://doi.org/10.1148/radiol.2020200370
Luers JC, Rokohl AC, Loreck N, Wawer Matos PA, Augustin M, Dewald F, et al. Olfactory and Gustatory Dysfunction in Coronavirus Disease 2019 (COVID-19). Clin Infect Dis. 2020 Nov 19;71(16):2262-4. doi: 10.1093/cid/ciaa525. PMID: 32357210; PMCID: PMC7197599. DOI: https://doi.org/10.1093/cid/ciaa525
Bousquet J, Akdis CA, Jutel M, Bachert C, Klimek L, Agache I, et al. and ARIA-MASK Study Group. Intranasal corticosteroids in allergic rhinitis in COVID-19 infected patients: An ARIA-EAACI statement. Allergy. 2020 Oct;75(10):2440-4. doi: 10.1111/all.14302. PMID: 32233040. DOI: https://doi.org/10.1111/all.14302
Seiden AM. Postviral olfactory loss. Otolaryngol Clin North Am. 2004 Dec;37(6):1159-66. doi: 10.1016/j.otc.2004.06.007. PMID: 15563908. DOI: https://doi.org/10.1016/j.otc.2004.06.007
Tong JY, Wong A, Zhu D, Fastenberg JH, Tham T. The Prevalence of Olfactory and Gustatory Dysfunction in COVID-19 Patients: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020 Jul;163(1):3-11. doi: 10.1177/0194599820926473. Epub 2020 May 5. PMID: 32369429. DOI: https://doi.org/10.1177/0194599820926473
Mao L, Jin H, Wang M, Hu Y, Chen S, He Q, et al. Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China. JAMA Neurol. 2020 Jun 1;77(6):683-90. doi: 10.1001/jamaneurol.2020.1127. PMID: 32275288; PMCID: PMC7149362. DOI: https://doi.org/10.1001/jamaneurol.2020.1127
Vaira LA, Salzano G, Deiana G, De Riu G. Anosmia and Ageusia: Common Findings in COVID-19 Patients. Laryngoscope. 2020 Jul;130(7):1787. doi: 10.1002/lary.28692. Epub 2020 Apr 15. PMID: 32237238; PMCID: PMC7228304. DOI: https://doi.org/10.1002/lary.28692
Bénézit F, Le Turnier P, Declerck C, Paillé C, Revest M, Dubée V, et al; RAN COVID Study Group. Utility of hyposmia and hypogeusia for the diagnosis of COVID-19. Lancet Infect Dis. 2020 Sep;20(9):1014-5. doi: 10.1016/S1473-3099(20)30297-8. Epub 2020 Apr 15. PMID: 32304632; PMCID: PMC7159866. DOI: https://doi.org/10.1016/S1473-3099(20)30297-8
Beltrán-Corbellini Á, Chico-García JL, Martínez-Poles J, Rodríguez-Jorge F, Natera-Villalba E, Gómez-Corral J, et al. Acute-onset smell and taste disorders in the context of COVID-19: a pilot multicentre polymerase chain reaction based case-control study. Eur J Neurol. 2020 Sep;27(9):1738-41. doi: 10.1111/ene.14273. Epub 2020 May 16. PMID: 32320508; PMCID: PMC7264557. DOI: https://doi.org/10.1111/ene.14273
Giacomelli A, Pezzati L, Conti F, Bernacchia D, Siano M, Oreni L, et al. Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study. Clin Infect Dis. 2020 Jul 28;71(15):889-90. doi: 10.1093/cid/ciaa330. PMID: 32215618; PMCID: PMC7184514. DOI: https://doi.org/10.1093/cid/ciaa330
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Copyright (c) 2023 Sibel Doğan Kaya, Suzan Şahin , Bülent Kaya, Gülfem Akengin Öcal, Sabahat Çağan Aktaş, Müge Tokatlı Çoban, Pınar Öngörü, Öznur Ak, Ayşe Batırel
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