Can mesenchymal stem cells ameliorate testicular damage? Current researches
Keywords:Azoospermia, Male infertility, Mesenchymal stem cells, Stem cell therapy, Testicular damage
Many recent studies have demonstrated the therapeutic effects of mesenchymal stem cells (MSC) in different disease models. Infertility is a global disease with a high prevalence. Non-obstructive azoospermia may occur due to genetic factors, exposure to toxic substances, anticancer treatments such as radiotherapy and chemotherapy and testicular torsion. Many experiments have been conducted to determine the efficacy of MSCs in the treatment of male infertility due to their differentiation capacity and paracrine effect. In these studies, the differentiation capacities of MSCs, obtained from diverse sources, to male germ cells were determined in vitro and their effects on testis niche were assessed by injection of MSCs into the testis. In this review, we addressed a few of the causes of non-obstructive azoospermia and summarized the current studies to determine the therapeutic effects of MSCs on testicular injury.
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