A case of laryngeal tuberculosis mimicking supraglottic carcinoma in a pregnant patient and literature review

Laryngeal tuberculosis mimicking supraglottic carcinoma



pregnancy, larynx, mass, tuberculosis


Tuberculosis (TB) is the most common granulomatous disease, but laryngeal involvement is rare. The risk of developing this clinical form is higher in immunocompromised patients due to primary infection or reactivation of latent TB. Laryngeal TB can be misdiagnosed as laryngeal cancer since they have similar macroscopic lesions, and both cause dysphonia. We present a case of laryngeal TB in a 37-week pregnant patient who complained of dysphonia, odynophagia, and dysphagia. A mass with supraglottic carcinoma findings was discovered during a laryngoscopic examination. The reason for presenting this case is to emphasize the necessity for a high degree of suspicion for laryngeal TB involvement in patients with upper respiratory tract lesions in regions with high TB prevalence, to achieve early diagnosis and treatment.


Download data is not yet available.


Paulauskienė I, Mickevičienė V. Dysphonia - the single symptom of rifampicin resistant laryngeal tuberculosis. Open Med (Wars). 2016;26(1):63-7. doi: 10.1515/med-2016-0013. DOI: https://doi.org/10.1515/med-2016-0013

Zenner D, Kruijshaar ME, Andrews N, Abubakar I. Risk of tuberculosis in pregnancy: a national, primary care-based cohort and self-controlled case series study. Am J Respir Crit Care Med. 2012;185(7):779-84. doi: 10.1164/rccm.201106-1083OC. DOI: https://doi.org/10.1164/rccm.201106-1083OC

Gupta A, Nayak U, Ram M, Bhosale R, Patil S, Basavraj A et al. Postpartum tuberculosis incidence and mortality among HIV-infected women and their infants in Pune, India, 2002-2005. Clin Infect Dis. 2007;45(2):241-9. doi: 10.1086/518974. DOI: https://doi.org/10.1086/518974

Geier J, Orlando B. Pulmonary and laryngeal tuberculosis in a 25-weeks' gestation parturient, diagnosed after failed tracheal intubation. Int J Obstet Anesth. 2018;33:75-7. doi: 10.1016/j.ijoa.2017.08.003. DOI: https://doi.org/10.1016/j.ijoa.2017.08.003

Benwill JL, Sarria JC. Laryngeal tuberculosis in the United States of America: a forgotten disease. Scand J Infect Dis. 2014;46(4):241-9. doi: 10.3109/00365548.2013.877157. DOI: https://doi.org/10.3109/00365548.2013.877157

Kurokawa M, Nibu K, Ichimura K, Nishino H. Laryngeal tuberculosis: A report of 17 cases. Auris Nasus Larynx. 2015;42(4):305-10. doi: 10.1016/j.anl.2015.02.012. DOI: https://doi.org/10.1016/j.anl.2015.02.012

Mnyani CN, McIntyre JA. Tuberculosis in pregnancy. BJOG. 2011;118(2):226-31. doi: 10.1111/j.1471-0528.2010.02771.x. DOI: https://doi.org/10.1111/j.1471-0528.2010.02771.x

Moon WK, Han MH, Chang KH, Im JG, Kim HJ, Sung KJ et al. CT and MR imaging of head and neck tuberculosis. Radiographics. 1997;17(2):391-402. doi: 10.1148/radiographics.17.2.9084080. DOI: https://doi.org/10.1148/radiographics.17.2.9084080

Nalini B, Vinayak S. Tuberculosis in ear, nose, and throat practice: its presentation and diagnosis. Am J Otolaryngol. 2006;27(1):39-45. doi: 10.1016/j.amjoto.2005.07.005. DOI: https://doi.org/10.1016/j.amjoto.2005.07.005

Williams RG, Douglas-Jones T. Mycobacterium marches back. J Laryngol Otol. 1995;109(1):5-13. doi: 10.1017/s0022215100129123. DOI: https://doi.org/10.1017/S0022215100129123

Smulders YE, De Bondt BJ, Lacko M, Hodge JA, Kross KW. Laryngeal tuberculosis presenting as a supraglottic carcinoma: a case report and review of the literature. J Med Case Rep. 2009;3:9288. doi: 10.1186/1752-1947-3-9288. DOI: https://doi.org/10.1186/1752-1947-3-9288

Harney M, Hone S, Timon C, Donnelly M. Laryngeal tuberculosis: an important diagnosis. J Laryngol Otol. 2000;114(11):878-80. doi: 10.1258/0022215001904220. DOI: https://doi.org/10.1258/0022215001904220

Lim JY, Kim KM, Choi EC, Kim YH, Kim HS, Choi HS. Current clinical propensity of laryngeal tuberculosis: review of 60 cases. Eur Arch Otorhinolaryngol. 2006;263(9):838-42. doi: 10.1007/s00405-006-0063-5. DOI: https://doi.org/10.1007/s00405-006-0063-5

Lin CJ, Kang BH, Wang HW. Laryngeal tuberculosis masquerading as carcinoma. Eur Arch Otorhinolaryngol. 2002;259(10):521-3. doi: 10.1007/s00405-002-0490-x. DOI: https://doi.org/10.1007/s00405-002-0490-x

Shin JE, Nam SY, Yoo SJ, Kim SY. Changing trends in clinical manifestations of laryngeal tuberculosis. Laryngoscope. 2000;110(11):1950-3. doi: 10.1097/00005537-200011000-00034. DOI: https://doi.org/10.1097/00005537-200011000-00034

Hunter AM, Millar JW, Wightman AJ, Horne NW. The changing pattern of laryngeal tuberculosis. J Laryngol Otol. 1981;95(4):393-8. doi: 10.1017/s0022215100090861. DOI: https://doi.org/10.1017/S0022215100090861

Yencha MW, Linfesty R, Blackmon A. Laryngeal tuberculosis. Am J Otolaryngol. 2000;21(2):122-6. doi: 10.1016/s0196-0709(00)85010-3. DOI: https://doi.org/10.1016/S0196-0709(00)85010-3

Rizzo PB, Da Mosto MC, Clari M, Scotton PG, Vaglia A, Marchiori C. Laryngeal tuberculosis: an often forgotten diagnosis. Int J Infect Dis. 2003;7(2):129-31. doi: 10.1016/s1201-9712(03)90008-7. DOI: https://doi.org/10.1016/S1201-9712(03)90008-7

Getahun H, Sculier D, Sismanidis C, Grzemska M, Raviglione M. Prevention, diagnosis, and treatment of tuberculosis in children and mothers: evidence for action for maternal, neonatal, and child health services. J Infect Dis. 2012;205(2):216-27. doi: 10.1093/infdis/jis009. DOI: https://doi.org/10.1093/infdis/jis009

Lazarus AA, Thilagar B. Tuberculosis of pericardium, larynx, and other uncommon sites. Dis Mon. 2007;53(1):46-54. doi: 10.1016/j.disamonth.2006.10.006. DOI: https://doi.org/10.1016/j.disamonth.2006.10.006

Lee JW, Ryu KA, Kwon KR, Koo BS. Primary pharyngeal tuberculosis presenting as a submucosal tumour. Int J Oral Maxillofac Surg. 2014;43(8):1005-7. doi: 10.1016/j.ijom.2014.02.001. DOI: https://doi.org/10.1016/j.ijom.2014.02.001

El Ayoubia FE, Charibaa I, El Ayoubia A, Charibab S, Essakalli L. Primary tuberculosis of the larynx. Eur Ann Otorhinolaryngol. 2014;131:361–4. doi: 10.1016/j.anorl.2013.10.005. DOI: https://doi.org/10.1016/j.anorl.2013.10.005

Vlastarakos PV, Manolopoulos L, Ferekidis E, Antsaklis A, Nikolopoulos TP. Treating common problems of the nose and throat in pregnancy: what is safe? Eur Arch Otorhinolaryngol. 2008;265(5):499-508. doi: 10.1007/s00405-008-0601-4. DOI: https://doi.org/10.1007/s00405-008-0601-4






Case Report

How to Cite

Baklacı D, Cakir Turhan A, Harma M. A case of laryngeal tuberculosis mimicking supraglottic carcinoma in a pregnant patient and literature review: Laryngeal tuberculosis mimicking supraglottic carcinoma. J Surg Med [Internet]. 2023 Oct. 10 [cited 2024 May 25];7(10):716-8. Available from: https://jsurgmed.com/article/view/7372