Evaluation of neurological and cardiac development of newborn infants born to mothers infected with COVID-19

Does COVID-19 affect the development of newborn infants?



Newborn, COVID-19, Neurodevelopment, Cardiac functions


Background/Aim: In the coronavirus disease 2019 (COVID-19) pandemic, which has been affecting the world for the last 2 years, pulmonary, cardiovascular, and neurological adverse effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported. These negative influences entail a risk for fetal progress. In this study, by performing a detailed clinical evaluation, postnatal ultrasonography, and echocardiography, we aimed to investigate potential neurological and cardiac complications of newborns born to pregnant women infected with COVID-19.

Methods: This prospective and cross-sectional study was conducted between January and July 2021. Newborn infants (0–28 days postpartum) born to mothers with proven COVID-19 infection by positive RT-PCR test during pregnancy were enrolled. Fetal cardiac development was evaluated by a pediatric cardiologist with an echocardiographic examination. Fetal neurologic evaluation was performed by a pediatric neurologist using both neurologic examination and transfontanelle ultrasonography (TFUS). Infants were reevaluated every 2 months until 6 months of age.

Results: Thirty-three female and 32 male infants born to 64 pregnant women, one being a twin birth, were included in the study. Seven women developed COVID-19 infection in the first trimester, 11 in the second trimester, and 46 in the third trimester. Neurological examination and TFUS were normal in all newborns except one with microcephaly. The etiologic cause could not be detected in this infant, and his neurodevelopment was normal in the follow-up. The cardiac examination did not reveal any significant disorders. Eleven infants failed the standard “Auditory Brainstem Response” (ABR) hearing screening test, so a second test was performed. Only two infants required further investigation after the second test.

Conclusion: We did not observe any neurologic and cardiologic teratogenic effects associated with COVID-19 infection during pregnancy.


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Carod-Artal FJ. Neurological complications of Zika virus infection. Expert Rev Anti Infect Ther. 2018;16:399-410. DOI: https://doi.org/10.1080/14787210.2018.1466702

Cengiz SD, Kaya C. TORCH Enfeksiyonları. Türkiye Klinikleri Dergisi Jinekoloji Obstetrik - Özel Konular. 2008;1:1-10.

Ornoy A, Ergaz Z. Parvovirus B19 infection during pregnancy and risks to the fetus. Birth Defects Res. 2017;109:311-23. DOI: https://doi.org/10.1002/bdra.23588

Davis NL, King CC, Kourtis AP. Cytomegalovirus infection in pregnancy. Birth Defects Res. 2017;109:336-46. DOI: https://doi.org/10.1002/bdra.23601

Chen H, Guo J, Wang C, Luo F, Yu X, Zhang W, et al. Clinical characteristics and intrauterine vertical transmission potential of COVID-19 infection in nine pregnant women: a retrospective review of medical records. Lancet. 2020;395:809-15. DOI: https://doi.org/10.1016/S0140-6736(20)30360-3

Schwartz DA. An Analysis of 38 Pregnant Women With COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes. Arch Pathol Lab Med. 2020;144:799-805. DOI: https://doi.org/10.5858/arpa.2020-0901-SA

Wang F, Kream RM, Stefano GB. Long-Term Respiratory and Neurological Sequelae of COVID-19. Med Sci Monit. 2020;26:1-10. DOI: https://doi.org/10.12659/MSM.928996

Iba T, Connors JM, Levy JH. The coagulopathy, endotheliopathy, and vasculitis of COVID-19. Inflamm Res. 2020;12:1–9. DOI: https://doi.org/10.1007/s00011-020-01401-6

Öncel MY, Akın İM, Kanburoğlu MK, Tayman C, Coşkun S, Narter F, et al. Neo-Covid Study Group. A multicenter study on epidemiological and clinical characteristics of 125 newborns born to women infected with COVID-19 by the Turkish Neonatal Society. Eur J Pediatr. 2021;180:733-42. DOI: https://doi.org/10.1007/s00431-020-03767-5

Kanburoğlu MK, Tayman C, Öncel MY, Akın İM, Can E, Demir N, et al. A Multicentered Study on Epidemiologic and Clinical Characteristics of 37 Neonates With Community-acquired COVID-19. Pediatr Infect Dis J. 2020;39:e297-302. DOI: https://doi.org/10.1097/INF.0000000000002862






Research Article

How to Cite

Ayar M, Gazeteci Tekin H, Sevinç Y, Öztekin D, Olukman Özgür. Evaluation of neurological and cardiac development of newborn infants born to mothers infected with COVID-19: Does COVID-19 affect the development of newborn infants?. J Surg Med [Internet]. 2022 Aug. 31 [cited 2022 Sep. 28];6(8):739-41. Available from: https://jsurgmed.com/article/view/7293